周圍神經(jīng)功能儲(chǔ)備的實(shí)驗(yàn)研究
發(fā)布時(shí)間:2018-06-29 16:21
本文選題:臂叢神經(jīng) + 顯微解剖 ; 參考:《吉林大學(xué)》2007年博士論文
【摘要】: 周圍神經(jīng)作為一種組織器官,與其他組織器官一樣具有一定的功能儲(chǔ)備,這種功能儲(chǔ)備為神經(jīng)損傷后的功能恢復(fù)提供了代償能力,從而為臨床應(yīng)用部分神經(jīng)束支移位修復(fù)周圍神經(jīng)損傷的可行性提供了生理解剖學(xué)依據(jù)。本項(xiàng)目利用神經(jīng)顯微解剖、DiI神經(jīng)束路示蹤及神經(jīng)電生理學(xué)等檢測(cè)技術(shù)研究大鼠主要神經(jīng)分支纖維在周圍神經(jīng)干內(nèi)不同平面(縱向)、不同部位(橫向)的功能定位情況、分布規(guī)律;探討周圍神經(jīng)功能儲(chǔ)備量及損傷后的代償能力;確定供體部分神經(jīng)束移位時(shí)最佳切取平面、切取部位和最大切取比例的量化指標(biāo),用于解決臂叢神經(jīng)根性撕脫傷及在神經(jīng)缺損行神經(jīng)移位時(shí)動(dòng)力神經(jīng)源不足的問題。為臨床更加有效、合理地應(yīng)用部分神經(jīng)束支移位術(shù)治療周圍神經(jīng)損傷提供可靠的理論和實(shí)驗(yàn)依據(jù),為擴(kuò)大神經(jīng)移位術(shù)臨床應(yīng)用范圍設(shè)計(jì)出科學(xué)可行的標(biāo)準(zhǔn)化手術(shù)方法。
[Abstract]:As a kind of tissue and organ, peripheral nerve has certain function reserve, which provides compensatory ability for functional recovery after nerve injury. It provides the physiological and anatomical basis for clinical application of partial nerve bundle branch transposition to repair peripheral nerve injury. The purpose of this project was to study the functional localization of the main nerve branching fibers in different planes (longitudinally) and at different positions (transverse) in the peripheral nerve trunk by means of nerve microanatomy and nerve tracer and neuroelectrophysiology. The distribution law, the quantity of peripheral nerve function reserve and the compensatory ability after injury, and the quantification index of the optimal cutting plane, the cutting position and the maximum cutting proportion of donor nerve bundle were determined. It is used to solve the problem of brachial plexus root avulsion injury and lack of dynamic nerve source during nerve transfer of nerve defect. To provide a reliable theoretical and experimental basis for the treatment of peripheral nerve injury with partial nerve bundle branch transposition, and to design a scientific and feasible standardized surgical method for expanding the scope of clinical application of nerve transposition.
【學(xué)位授予單位】:吉林大學(xué)
【學(xué)位級(jí)別】:博士
【學(xué)位授予年份】:2007
【分類號(hào)】:R651;R322
【引證文獻(xiàn)】
相關(guān)碩士學(xué)位論文 前1條
1 欒志勇;正常大鼠坐骨神經(jīng)和不等徑小間隙套接神經(jīng)再生的形態(tài)學(xué)研究[D];吉林大學(xué);2011年
,本文編號(hào):2082680
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