本文選題：考試應(yīng)激 + 補(bǔ)體��； 參考：《大連醫(yī)科大學(xué)》2005年碩士論文

【摘要】：應(yīng)激(stress)是指機(jī)體針對外界刺激的非特異性反應(yīng),即無論外界刺激的性質(zhì)如何,機(jī)體總是做出大致相同的反應(yīng)。心理應(yīng)激可以改變一個人原有的健康生活方式和行為模式,因此,心理應(yīng)激對于機(jī)體神經(jīng)、內(nèi)分泌、免疫系統(tǒng)的影響越來越受到人們的重視。許多研究表明,心理應(yīng)激是影響身體健康的重要因素,與許多高發(fā)疾病,如:心臟病,高血壓,糖尿病等,有著密切的聯(lián)系。本文旨在探討考試應(yīng)激狀態(tài)下人體免疫的變化及其與人格類型、MICA 基因多態(tài)性的關(guān)系。 從某醫(yī)科大學(xué)在讀二年級學(xué)生中隨機(jī)選取 24 名,其中男性 13 名,女性 11 名,年齡在 19-21 歲之間;對其進(jìn)行艾森克(EPQ)人格測試,可以將其分為外向穩(wěn)定型、外向不穩(wěn)定型、內(nèi)向穩(wěn)定型、內(nèi)向不穩(wěn)定型等類型。分別于考試前一天及開學(xué)第一周晨空腹采血,通過免疫散射比濁法測定學(xué)生免疫球蛋白及補(bǔ)體的含量,通過放射免疫技術(shù)(Radioimmunoassay,RIA)測定受試者血清中皮質(zhì)醇(cortisol)的水平,同時采用聚合酶鏈反應(yīng)(Polymerase Chain Reaction, PCR)技術(shù)檢測“MHC-Ⅰ相關(guān)基因 A”(MICA)多態(tài)性,通過統(tǒng)計學(xué)方法計算應(yīng)激免疫與遺傳的關(guān)系及與人格的相關(guān)性。結(jié)果表明,期末考試血清皮質(zhì)醇濃度為 549.7nmol/L,開學(xué)后第一周為 358.4nmol/L,考試前較考試后升高,有統(tǒng)計學(xué)意義(P0.05)�？荚嚽�,補(bǔ)體 C3 濃度為
[Abstract]:Stress is the nonspecific response of the body to the external stimulus, that is, the body always makes the same response regardless of the nature of the external stimulus. Psychological stress can change a person's original healthy life style and behavior pattern. Therefore, people pay more and more attention to the influence of psychological stress on nervous, endocrine and immune system. Many studies have shown that psychological stress is an important factor affecting physical health and is closely related to many diseases such as heart disease hypertension diabetes and so on. The purpose of this study was to investigate the changes of human immunity under examination stress and its relationship with the polymorphism of MICA gene in personality types. Twenty-four students in the second year were randomly selected from a medical university, including 13 males and 11 females. The personality test of Eysenck EPQ can be divided into three types: extroverted stable type, extroverted unstable type, introverted unstable type and so on. Fasting blood samples were collected one day before the examination and the first week of school term. The contents of immunoglobulin and complement in students were determined by immune turbidimetry, and the serum cortisol levels were measured by radioimmunoassay (RIA). The polymorphism of "MHC- 鈪，

本文編號：1999955