發(fā)布時間：2018-06-07 02:44

  本文選題：樹突狀細胞 + 發(fā)熱溫度處理　； 參考：《浙江大學》2005年博士論文

【摘要】：發(fā)熱(fever)是一種復雜的生理反應,病理條件下的發(fā)熱主要是由各種病原體感染引起的,如流感病毒、SARS病毒、肺炎球菌、傷寒桿菌等引起的發(fā)熱。發(fā)熱也可以由非感染性疾病引起,像中暑、惡性腫瘤、白血病等均可引起的發(fā)熱。多種細胞因子參與發(fā)熱的形成,IL-1β、IL-6、IL-8、IFN-γ,MIP-1a等內源性熱源促進發(fā)熱的形成;IL-10作為內源性抗熱源則抑制發(fā)熱的形成;根據(jù)實驗體系不同,TNF-a則具有熱源和抗熱源的雙重作用。 目前認為,發(fā)熱有助于宿主抵御細菌、真菌和病毒感染,提高受感染動物的存活率,縮短發(fā)病時間,加快病原體的清除過程。但對于其機制,目前了解并不多。近年來的研究表明,發(fā)熱可從多個方面調節(jié)宿主的免疫應答,發(fā)熱可增強體液和細胞免疫,發(fā)熱可增強樹突狀細胞(dendritic cell,DC)的抗原遞呈功能,促進皮膚郎格漢斯氏細胞遷移。此外,發(fā)熱也可以促進淋巴細胞向次級淋巴組織歸巢,促進中性粒細胞釋放一氧化氮和氧代謝中間物,增強先天免疫功能,發(fā)熱還可以調節(jié)LPS誘導的IL-12等多種細胞因子的分泌,提高受細菌感染小鼠的存活率。 Toll樣受體(Toll-like receptors,TLRs)是一類重要的模式識別受體(Pattern recognition receptor,PRR),在識別微生物感染的過程中發(fā)揮重要的作用。Toll樣受體識別病原體的一些高度保守的分子結構,即病原體相關
[Abstract]:Fever is a complex physiological response. Fever under pathological conditions is mainly caused by the infection of various pathogens, such as influenza virus SARS virus, pneumococcus, typhoid bacillus and so on. Fever can also be caused by non-infectious diseases such as heat stroke, malignant tumors, leukemia, etc. Many cytokines are involved in the formation of fever. The endogenous heat sources such as IL-1 尾 IL-6, IL-8, IFN- 緯 -MIP-1a, and so on, promote the formation of fever. As an endogenous anti-heat source, IL-10 inhibits the formation of fever, and according to the different experimental systems, TNF-a has the dual effects of heat source and anti-heat source. It is believed that fever can help the host resist bacterial, fungal and viral infections, improve the survival rate of infected animals, shorten the onset time, and speed up the process of pathogen clearance. However, little is known about its mechanism. Recent studies have shown that fever can regulate host immune response from many aspects, fever can enhance humoral and cellular immunity, fever can enhance the antigen-presenting function of dendritic cells (DC) and promote the migration of Langerhans cells in skin. In addition, fever can also promote lymphocyte homing to secondary lymphoid tissue, promote neutrophil release of nitric oxide and oxygen metabolic intermediates, enhance innate immune function, and regulate the secretion of IL-12 and other cytokines induced by LPS. To improve the survival rate of mice infected with bacteria. Toll-like receptor (TLRs) is an important pattern recognition receptor, which plays an important role in the identification of microbial infections. Toll-like receptors recognize some highly conserved molecular structures of pathogens, that is, pathogen-related.
【學位授予單位】：浙江大學
【學位級別】：博士
【學位授予年份】：2005
【分類號】：R392

【引證文獻】

相關碩士學位論文 前1條

1 許軼曼;肺癌陰虛證抗炎性細胞因子變化規(guī)律的研究[D];鄭州大學;2007年

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本文編號：1989384