本文選題：乙醇 + 乙醛　； 參考：《湖南師范大學(xué)》2006年碩士論文

【摘要】：人類過(guò)量飲酒導(dǎo)致的問(wèn)題十分嚴(yán)重,因飲酒而產(chǎn)生的疾病中尤以心腦血管疾病為最。酒精在體內(nèi)代謝的中間產(chǎn)物為乙醛。以往對(duì)神經(jīng)、心臟影響的研究多側(cè)重于乙醇的影響,國(guó)外雖對(duì)乙醛的影響有一些研究,但對(duì)乙醛、乙醇兩者作用的比較研究甚少。針對(duì)飲酒對(duì)心腦血管的影響,我們選擇了以神經(jīng)和心臟為對(duì)象開(kāi)展乙醇、乙醛作用的比較研究,以探討兩者對(duì)器官影響的作用大小及相關(guān)機(jī)制,為進(jìn)一步的研究提供基礎(chǔ)和參考。 將含有不同濃度的乙醇、乙醛的任氏液滴加到蟾蜍坐骨神經(jīng)表面,30秒后測(cè)定神經(jīng)干刺激閾值、最大刺激值,復(fù)合動(dòng)作電位峰值和不應(yīng)期等電生理指標(biāo)。結(jié)果表明:乙醇在86～515 mmol/L濃度范圍內(nèi)能使神經(jīng)標(biāo)本的不應(yīng)期縮短,刺激閾值、最大刺激值減小,復(fù)合動(dòng)作電位峰值升高;而乙醛在8.5～42.8 mmol/L濃度范圍內(nèi)即能對(duì)標(biāo)本產(chǎn)生上述影響。如果乙醇濃度提高至859～1545 mmol/L,則神經(jīng)標(biāo)本表現(xiàn)出不應(yīng)期延長(zhǎng),刺激閾值、最大刺激值提高,復(fù)合動(dòng)作電位降低(仍高于空白對(duì)照組)等現(xiàn)象;而使神經(jīng)標(biāo)本表現(xiàn)出相同現(xiàn)象的乙醛濃度只相應(yīng)地提升為85.6～429 mmol/L。用高于1.5 mol/L的乙醇處理神經(jīng)標(biāo)本,可能對(duì)其造成不可恢復(fù)性損傷,而乙醛的最低損傷濃度為0.5 mol/L左右。 在對(duì)心臟的影響研究中,用不同濃度的乙醇和乙醛對(duì)蛙心標(biāo)本進(jìn)行灌流,用BL-420~+系統(tǒng)對(duì)給藥前后心臟的心率作記錄,以研究乙醇和乙醛對(duì)離體心臟和神經(jīng)干的影響及可能機(jī)制。結(jié)果顯示乙醇對(duì)心臟
[Abstract]:The problems caused by excessive drinking in humans are very serious, especially cardiovascular and cerebrovascular diseases. The intermediate product of alcohol metabolism in vivo is acetaldehyde. Previous studies on the effects of nerve and heart focused on the effects of ethanol. Although there are some studies on the effects of acetaldehyde in foreign countries, there are few comparative studies on the effects of acetaldehyde and ethanol. In view of the effects of alcohol drinking on cardiovascular and cerebrovascular diseases, we chose to study the effects of ethanol and acetaldehyde on nerves and hearts in order to explore the effects of alcohol and acetaldehyde on organs and the related mechanisms. To provide the basis and reference for further research. Ren's drops containing different concentrations of ethanol and acetaldehyde were added to the sciatic nerve surface of toad. After 30 seconds, the nerve stem stimulation threshold, the maximum stimulation value, the peak value of complex action potential and the refractory period were measured. The results showed that ethanol could shorten the refractory period, reduce the stimulation threshold, decrease the maximum stimulation value and increase the peak value of compound action potential in the range of 86 ~ 515 mmol/L, while acetaldehyde could produce the above effects in the range of 8.5 ~ 42.8 mmol/L. If ethanol concentration was increased to 859 ~ 1545 mmol / L, the nerve specimens showed prolonged refractory period, increased stimulation threshold, increased maximum stimulation value, and decreased complex action potential (still higher than that of the blank control group). The acetaldehyde concentration, which showed the same phenomenon in the nerve samples, only increased to 85.6 mmol-1 / L at 429 mmol 路L ~ (-1) 路L ~ (-1). The nerve specimen treated with ethanol for more than 1.5 mol/L may cause non-restorative injury, while the lowest injury concentration of acetaldehyde is about 0.5 mol/L. In order to study the effect of ethanol and acetaldehyde on isolated heart and nerve stem, the frog heart was perfused with different concentrations of ethanol and acetaldehyde, and the heart rate before and after administration was recorded by BL-420 ~ system in order to study the effect of ethanol and acetaldehyde on isolated heart and nerve trunk. The results showed that ethanol had effect on the heart.
【學(xué)位授予單位】：湖南師范大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2006
【分類號(hào)】：R363

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本文編號(hào)：1969220