本文選題：細(xì)菌 + 噬菌體　； 參考：《生物技術(shù)通報(bào)》2014年07期

【摘要】：抗生素治療盡管有幾十年有效治療的歷史,但隨著越來(lái)越多耐/抗藥性細(xì)菌的出現(xiàn),細(xì)菌對(duì)抗生素的抗藥性已成為一個(gè)大問(wèn)題。噬菌體治療是使用噬菌體作為抗菌劑來(lái)感染細(xì)菌株系,它一直是人們倡導(dǎo)的一個(gè)很有前途的常規(guī)抗生素治療的替代方案。然而,由于細(xì)菌與噬菌體的協(xié)同進(jìn)化中,細(xì)菌可以通過(guò)多種機(jī)制獲得對(duì)噬菌體的抗性。因此,人們對(duì)噬菌體治療抱有期望的同時(shí),也關(guān)注噬菌體治療長(zhǎng)時(shí)間的使用之后,是否會(huì)與抗生素使用之后結(jié)果相類似,導(dǎo)致抗性細(xì)菌病原菌感染的治療困難。綜述了細(xì)菌-噬菌體協(xié)同進(jìn)化中細(xì)菌病原菌對(duì)有感染能力的噬菌體是否會(huì)產(chǎn)生抗性,及其在噬菌體治療中影響的爭(zhēng)論,并展望了噬菌體治療的潛在前景。
[Abstract]:Although antibiotic therapy has a history of effective treatment for several decades, with the emergence of more and more resistant / resistant bacteria, the resistance of bacteria to antibiotics has become a major problem. Bacteriophage therapy is a promising alternative to conventional antibiotic therapy, which uses bacteriophage as an antimicrobial agent to infect bacterial strains. However, because of the co-evolution of bacteriophage and bacteria, bacteria can obtain bacteriophage resistance through a variety of mechanisms. Therefore, people have expectations of phage therapy, but also pay attention to whether the results of bacteriophage therapy after a long period of use will be similar to those after antibiotic use, leading to the difficulty of treatment of resistant bacterial pathogens infection. This paper reviews the debate on whether bacterial pathogens develop resistance to bacteriophages with infectious ability and their influence on phage therapy in the co-evolution of bacteriophage and bacteriophage. The potential prospect of bacteriophage therapy is also prospected.
【作者單位】： 貴州省煙草科學(xué)研究院中國(guó)煙草分子遺傳重點(diǎn)實(shí)驗(yàn)室;
【基金】：黔煙科合(2012-03),公益性行業(yè)(農(nóng)業(yè))科研專項(xiàng)經(jīng)費(fèi)(201103004)
【分類號(hào)】：R378

【相似文獻(xiàn)】

相關(guān)碩士學(xué)位論文 前1條

1 付鳳洋;中華按蚊不同種群溴氰菊酯抗性生測(cè)及機(jī)制初步研究[D];重慶師范大學(xué);2013年

，

本文編號(hào)：1936129