本文選題：含腸 + 激酶　； 參考：《浙江大學(xué)》2005年碩士論文

【摘要】：前言 2型糖尿病主要的病理生理改變是胰島素抵抗(Insulin resistance,IR)和胰島素分泌缺陷,兩者相互作用共同導(dǎo)致疾病的發(fā)生和發(fā)展。目前尚無有效的藥物能同時針對2型糖尿病發(fā)病機制的兩個方面即IR和胰島素分泌缺陷進(jìn)行治療。脂聯(lián)素(adiponectin)是脂肪細(xì)胞分泌的特異性蛋白質(zhì),具有增加胰島素敏感性,減輕IR,降低血糖、血脂、抗炎,抗動脈粥樣硬化等作用。adiponectin的功能域為C端球狀域(即脂聯(lián)素球狀域,globular adiponectin,gAdiponectin),具有全長脂聯(lián)素的功能,在骨骼肌中,其活性遠(yuǎn)大于全長的脂聯(lián)素。胰升糖素樣肽-1(Glucagon-like Peptide-1,GLP-1)是胰島α細(xì)胞和腸粘膜L細(xì)胞分泌的一種激素。GLP-1功能域在N端,可與胰島β細(xì)胞上的GLP-1受體結(jié)合,促進(jìn)胰島素的釋放,此作用具有血糖依賴性。GLP-1的體內(nèi)半衰期很短,尚不能應(yīng)用于臨床。在體內(nèi)GLP-1主要經(jīng)二肽肽酶Ⅳ(Dipeptidyl peptidase-Ⅳ,DPP-Ⅳ)的切割和腎臟濾過而清除。尋找有效的方法對GLP-1進(jìn)行分子改造獲得GLP-1類似肽
[Abstract]:Preface
The main pathophysiological changes in type 2 diabetes are insulin resistance (Insulin resistance, IR) and insulin secretion defects. The interaction of the two causes the occurrence and development of the disease. There is no effective drug at the same time to treat the two aspects of the pathogenesis of type 2 diabetes, namely, IR and insulin secretion defects. Adiponectin (ADIP Onectin) is a specific protein secreted by adipocytes, which can increase insulin sensitivity, reduce IR, reduce blood sugar, blood lipid, anti-inflammatory, and anti atherosclerosis, and the function domain of.Adiponectin is C terminal sphere domain (i.e., adiponectin sphere, globular adiponectin, gAdiponectin), with full adiponectin function, in skeletal muscle, its activity The sex is far greater than adiponectin. -1 (Glucagon-like Peptide-1, GLP-1) is a hormone.GLP-1 functional domain secreted by pancreatic islet alpha cells and intestinal mucosa L cells at the N end, which can bind to the GLP-1 receptor on the islet beta cells and promote the release of insulin. This apparatus has a short half-life in the body with Blood Glucose dependent.GLP-1 and is not yet effective. It can be applied to clinical. In vivo GLP-1 is cleared by two peptidase IV (Dipeptidyl peptidase- IV, DPP- IV) and renal filtration. An effective method for molecular modification of GLP-1 to obtain a GLP-1 similar peptide
【學(xué)位授予單位】：浙江大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2005
【分類號】：R341

【引證文獻(xiàn)】

相關(guān)碩士學(xué)位論文 前1條

1 呂晶;人脂聯(lián)素球狀域—胰升糖素樣肽-1類似肽融合蛋白的表達(dá)及降糖作用測定[D];浙江大學(xué);2011年

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本文編號：1924443