發(fā)布時間：2018-05-07 06:57

  本文選題：經(jīng)顱磁刺激 + 腦電�。� 參考：《中國科學(xué)院研究生院（電工研究所）》2006年碩士論文

【摘要】：經(jīng)顱磁刺激(Transcranial magnetic stimulation, TMS)作為一種無創(chuàng)、無痛的刺激方式,在診斷和治療方面有廣闊的應(yīng)用前景。目前在癲癇治療方面,使用低頻經(jīng)顱磁刺激(low-frequency rTMS)進(jìn)行輔助治療的研究比較多,但是其治療原理還在研究之中。腦電分析是電生理研究的一項重要手段,近期研究表明腦電信號具有一定的混沌特性。鑒于低頻rTMS研究的重要性,以及低頻rTMS前后腦電研究的不足,本文從腦電的非線性動力學(xué)和功率譜方面分析了低頻rTMS對大鼠大腦的影響。 本文首先研究了低頻rTMS對正常大鼠腦電的影響,使用了100個頻率為0.5Hz的閾上經(jīng)顱磁刺激,采集刺激前后大鼠的腦電信號進(jìn)行分析,同時還進(jìn)行了對照組實驗。分析結(jié)果表明,rTMS刺激后大鼠腦電相關(guān)維數(shù)和功率譜的高頻部分,比刺激前降低,并具有顯著性意義,而對照組沒有此結(jié)果。該結(jié)果表明低頻rTMS對大腦活動有一定抑制作用。 本文還研究了500個0.5Hz的rTMS對誘發(fā)癲癇的大鼠的作用。實驗結(jié)果表明,低頻rTMS有降低大鼠癲癇發(fā)作級別的趨勢。同時本文還得到了大鼠癲癇發(fā)作各個典型階段的腦電波形,并分析了腦電相關(guān)維數(shù)在發(fā)作過程中的變化規(guī)律。 最后,本文討論了TMS運(yùn)動誘發(fā)電位在研究大鼠脊髓損傷方面的應(yīng)用。結(jié)果表明,TMS運(yùn)動誘發(fā)電位的潛伏期可以反映大鼠脊髓損傷的情況。本文還將獨(dú)立成分分析(ICA)方法用于運(yùn)動誘發(fā)電位提取,發(fā)現(xiàn)該方法有助于分析起始點不夠明確的運(yùn)動誘發(fā)電位。
[Abstract]:Transcranial magnetic stimulation (TMS), as a noninvasive and painless stimulation, has a broad prospect in diagnosis and treatment. At present, there are many studies on the use of low-frequency low-frequency magnetic stimulation in epilepsy therapy, but the therapeutic principle is still under study. Electroencephalogram (EEG) analysis is an important method in electrophysiology research. Recent studies have shown that EEG signals have some chaotic characteristics. In view of the importance of low-frequency rTMS research and the shortage of EEG research before and after low-frequency rTMS, the effects of low-frequency rTMS on the brain of rats were analyzed in terms of nonlinear dynamics and power spectrum of low-frequency rTMS. In this paper, we first studied the effect of low-frequency rTMS on the EEG of normal rats. We used 100 transcranial transcranial magnetic stimuli with frequency of 0.5Hz to analyze the EEG of rats before and after stimulation, and at the same time, we carried out the experiment of control group. The results showed that the correlation dimension of EEG and the high frequency part of power spectrum after rTMS stimulation were significantly lower than those before stimulation, but there was no such result in the control group. The results suggest that low frequency rTMS has a certain inhibitory effect on brain activity. We also studied the effects of 500 0.5Hz rTMS on epileptic rats. The results showed that low frequency rTMS had a tendency to decrease the seizure grade of rats. At the same time, the electroencephalogram of different typical stages of epileptic seizure in rats was obtained, and the variation of EEG correlation dimension in the course of seizure was analyzed. Finally, the application of TMS motor evoked potential in the study of spinal cord injury in rats was discussed. The results showed that the latency of motor evoked potential of TMS could reflect the spinal cord injury in rats. The independent component analysis (ICA) method is also applied to the extraction of motor evoked potentials. It is found that this method is helpful to the analysis of motor evoked potentials whose starting point is not clear enough.
【學(xué)位授予單位】：中國科學(xué)院研究生院（電工研究所）
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2006
【分類號】：R35

【引證文獻(xiàn)】

相關(guān)博士學(xué)位論文 前1條

1 楊碩;磁刺激頭部的感應(yīng)電場分析及其對神經(jīng)功能影響的研究[D];河北工業(yè)大學(xué);2007年

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本文編號：1855876