發(fā)布時(shí)間：2018-04-29 19:45

  本文選題：幽門螺桿菌 + ureB基因　； 參考：《鄭州大學(xué)》2006年碩士論文

【摘要】：幽門螺桿菌(Helicobacter pylori，Hp)感染是世界上最常見(jiàn)的感染之一，目前Hp已經(jīng)成為公認(rèn)的人類慢性活動(dòng)性胃炎和消化性潰瘍的主要致病因子，并與胃癌、胃MALT惡性淋巴瘤的發(fā)生密切相關(guān)。目前，臨床上主要采用抗生素治療Hp的感染，短期內(nèi)雖有較好的療效，但由于存在細(xì)菌耐藥性不斷增加、治療費(fèi)用高、不能防止復(fù)發(fā)和重復(fù)感染等問(wèn)題，使這類方案的實(shí)用性受限。疫苗接種經(jīng)濟(jì)而簡(jiǎn)便，可在人群中大規(guī)模運(yùn)用，并且對(duì)耐藥細(xì)菌仍然有效，因此研究幽門螺桿菌疫苗有重要意義。 雖然Hp疫苗研究取得了一定成績(jī)，但一直令學(xué)者們遺憾的是單一抗原成分免疫動(dòng)物時(shí)，獲得的保護(hù)率均不理想，，為了克服單種抗原免疫性較弱的不足有學(xué)者建議將多種抗原成分聯(lián)合起來(lái)制作疫苗。這就為今后Hp疫苗的探索和研究指出了發(fā)展方向。 國(guó)內(nèi)外大量研究證實(shí)UreB有較好的免疫保護(hù)效果，而且已有研究將UreB疫苗制劑進(jìn)入到二期臨床試驗(yàn)，證實(shí)Hp尿素酶在人體有效。已有研究結(jié)果顯示Hp外膜蛋白中有些具有良好的免疫學(xué)活性，Omp11是Hp的一種外膜蛋白，其編碼基因具有高度保守性，經(jīng)動(dòng)物實(shí)驗(yàn)鑒定亦取得了較好的免疫保護(hù)效果，為重要的免疫抗原。
[Abstract]:Helicobacter pylori (Helicobacter pylori) infection is one of the most common infections in the world. At present, HP has become the main pathogenic factor of chronic active gastritis and peptic ulcer in human, and is closely related to the occurrence of gastric cancer and gastric MALT malignant lymphoma. At present, antibiotics are mainly used in the treatment of HP infection in the short term, but because of the increasing drug resistance of bacteria and the high cost of treatment, it can not prevent recurrence and repeated infection. The practicability of such schemes is limited. Vaccination is economical and simple, can be used in large scale in population, and is still effective against drug-resistant bacteria, so it is of great significance to study Helicobacter pylori vaccine. Although some achievements have been made in the research of HP vaccine, it has always been a pity to scholars that the protective rate obtained when immunizing animals with a single antigen component is not satisfactory. In order to overcome the weak immunogenicity of a single antigen, some scholars have suggested that a variety of antigen components should be combined to make a vaccine. This pointed out the direction of development for the exploration and research of HP vaccine in the future. A large number of studies at home and abroad have confirmed that UreB has a good immune protection effect. Moreover, it has been studied that UreB vaccine preparation has been put into the second phase clinical trial, which proves that HP urease is effective in human body. It has been shown that some of HP outer membrane proteins have good immunological activity. Omp11 is an outer membrane protein of HP, and its coding gene is highly conserved. Is an important immune antigen.
【學(xué)位授予單位】：鄭州大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2006
【分類號(hào)】：R392.1

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相關(guān)期刊論文 前10條

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3 陳潔,陳e

本文編號(hào)：1821300