本文選題：脊髓圓錐末端 + 頂臀長(CRL)　； 參考：《鄭州大學(xué)》2005年碩士論文

【摘要】：目的 小兒脊髓栓系綜合征(Tethered cord syndrome,TCS)是小兒外科常見疾病。目前診斷仍沿用歐洲人的診斷標(biāo)準(zhǔn),即脊髓圓錐末端位于L_3以下并出現(xiàn)相應(yīng)的臨床癥狀。治療主要是手術(shù)松解,但仍有不少患兒療效并不滿意。近年對亞洲人脊髓圓錐末端位置研究,結(jié)果發(fā)現(xiàn)亞洲人脊髓圓錐末端位置與歐洲人之間存在爭議。神經(jīng)干細(xì)胞研究進(jìn)展給該病帶來希望。本實(shí)驗(yàn)以探索國人胎兒新生兒脊髓圓錐末端位置,以便對胎兒新生兒期脊髓栓系或脊髓栓系綜合征早期作出診斷及指導(dǎo)腰部腦脊液穿刺、麻醉等操作;研究兒童終絲中神經(jīng)干細(xì)胞(Neural stem cells,NSCs)的分布,為脊髓栓系綜合征及其它中樞神經(jīng)系統(tǒng)疾病的治療提供新的材料。 材料和方法 1.對124例胎兒和死亡足月新生兒進(jìn)行解剖,游離出第十二肋及各椎體橫突作為標(biāo)記,測量項(xiàng)臀長(crown—rump length,CRL),按Vettivel分組方法共分Ⅷ組。脊髓圓錐末端確定為:最后一對神經(jīng)根連接處水平。圓錐末端位于橫突基部上緣時(shí)表示在椎體上緣、位于橫突基部下緣時(shí)表示在椎體中點(diǎn)、圓錐末端位于兩橫突之間表示在椎體下緣、上下緣之間對應(yīng)的為椎間盤。所得結(jié)果進(jìn)行統(tǒng)計(jì)學(xué)處理。 2.取TCS患者內(nèi)終絲近遠(yuǎn)端40例,用免疫組織化學(xué)的方法進(jìn)行染色,觀察神經(jīng)上皮干細(xì)胞蛋白(Nestin)表達(dá)。 結(jié)果
[Abstract]:PurposeTethered cord syndrome is a common disease in pediatric surgery.At present, the European diagnostic criteria are still used, that is, the end of the spinal cones is located below L\ +\ +\ {\}\ {\}\ ^\\\The main treatment is surgical release, but there are still many children with unsatisfactory results.In recent years, we have studied the terminal position of the spinal cones in Asian people and found that there is a dispute between the terminal position of the spinal cones in Asians and the Europeans.The progress of neural stem cell research brings hope to the disease.The purpose of this study was to explore the terminal position of spinal cord cones in Chinese fetus, so as to diagnose the tethered cord or tethered cord syndrome early and to guide the operation of lumbar cerebrospinal fluid puncture and anaesthesia.To study the distribution of neural stem cells in terminal filaments of children, and to provide new materials for the treatment of tethered cord syndrome and other central nervous system diseases.Materials and methods1.124 fetuses and dead full-term newborns were dissected. The twelfth rib and the transverse process of vertebrae were separated as markers to measure the length of nail-buttock crown-rump length of CRLL. According to the method of Vettivel grouping, they were divided into 鈪，

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