本文選題：免疫系統(tǒng) + Penna模型�。� 參考：《大連理工大學(xué)》2007年碩士論文

【摘要】： 免疫學(xué)是當(dāng)前生命科學(xué)研究的熱點。免疫系統(tǒng)是一個復(fù)雜的自適應(yīng)系統(tǒng)，可以保護(hù)生物體不受外部病原體侵害。應(yīng)用數(shù)學(xué)模型對免疫系統(tǒng)進(jìn)行研究，能夠加深我們對于免疫系統(tǒng)的進(jìn)一步了解和認(rèn)識。通過把免疫系統(tǒng)研究中的形態(tài)空間模型和生物種群研究中的Penna模型結(jié)合到一起，本文研究了種群免疫領(lǐng)域的一些問題，并對其進(jìn)行了探討。 下面將本文的所做的工作以及主要結(jié)論介紹如下： 首先，本文對于生物免疫系統(tǒng)的組成、結(jié)構(gòu)、機(jī)制及其性質(zhì)等問題進(jìn)行了較為全面的綜述。討論了免疫系統(tǒng)是如何保護(hù)生物體、免疫系統(tǒng)是如何快速進(jìn)化、以及免疫系統(tǒng)的復(fù)雜性等相關(guān)問題。 其次，文本從生物學(xué)角度介紹了模擬研究免疫系統(tǒng)的幾種方法，其中包括：形態(tài)空間模型、元胞自動機(jī)模型，多agent模型等等。詳細(xì)的介紹了免疫系統(tǒng)模型的發(fā)展過程，各種不同模型的特點及其應(yīng)用。 再次，通過把免疫系統(tǒng)中的形態(tài)空間模型以及修改了的Penna種群演化模型相結(jié)合，文本研究了種群免疫過程中相關(guān)問題。在本文中，種群中的個體信息由基本的Penna模型進(jìn)行捕述，每個個體的免疫系統(tǒng)由形態(tài)空間模型進(jìn)行描述。在Penna模型的基礎(chǔ)上，，本文規(guī)定了個體的死亡(先天疾病、后天病死、老死)、繁殖、感染和免疫等規(guī)則。進(jìn)而，本文對于免疫系統(tǒng)的記憶性、快速進(jìn)化性以及疫苗在生物種群數(shù)量上的影響作用進(jìn)行了研究。 最后，我們給出了種群免疫模型的研究結(jié)論。我們發(fā)現(xiàn)在存在病毒影響的情況下，免疫系統(tǒng)的記憶性、快速進(jìn)化性以及疫苗對于維持種群數(shù)目起到了重要的作用，是生物體不可或缺的一道屏障。
[Abstract]:Immunology is the focus of life science research.The immune system is a complex adaptive system that protects organisms from external pathogens.The application of mathematical models to the study of the immune system can deepen our understanding of the immune system.By combining the morphological space model in immune system research with the Penna model in biological population research, this paper studies some problems in the field of population immunization and discusses them.The work done and the main conclusions of this article are described below:Firstly, the composition, structure, mechanism and properties of biological immune system are reviewed.This paper discusses how the immune system protects organisms, how the immune system evolves rapidly, and the complexity of the immune system.Secondly, several methods of simulating immune system are introduced from the biological point of view, including morphological space model, cellular automata model, multiple agent model and so on.The development process of immune system model, the characteristics of different models and their applications are introduced in detail.Thirdly, by combining the morphological space model of immune system with the modified Penna population evolution model, the paper studies the related problems in the process of population immunization.In this paper, the individual information in the population is captured by the basic Penna model, and the immune system of each individual is described by the morphological space model.On the basis of Penna model, the rules of individual death (congenital disease, acquired disease, old death, reproduction, infection and immunity) are defined in this paper.Furthermore, the memory, rapid evolution of immune system and the effect of vaccine on population size were studied.Finally, we give the conclusion of the population immune model.We found that the memory, rapid evolution and vaccine of the immune system play an important role in maintaining the population number in the presence of virus, which is an indispensable barrier for organisms.
【學(xué)位授予單位】：大連理工大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2007
【分類號】：R392

【引證文獻(xiàn)】

相關(guān)期刊論文 前1條

1 陳瑋;劉啟順;李曙光;趙小明;彭強(qiáng);高振;胡建恩;杜昱光;;微藻多糖生物活性研究進(jìn)展[J];中國海洋藥物;2012年03期

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