發(fā)布時間：2018-04-10 05:11

  本文選題：超聲造影劑　切入點：微泡　出處：《上海交通大學》2007年碩士論文

【摘要】： 超聲造影劑微泡是現(xiàn)代醫(yī)學中十分活躍的領域。在超聲診斷領域中利用微泡的散射特性增強超聲成像效果,以及利用微泡的空化效應在超聲治療領域的應用都得到了相當廣泛的研究。 本文從空化氣泡的聲致發(fā)光實驗、理論求解和比較帶球殼微泡和空化氣泡的動力學特性,和微泡在單雙頻超聲換能器下的與生物組織的作用效果出發(fā),研究微泡的超聲特性以及微泡對生物組織的作用效果。 首先測量單泡聲致發(fā)光Mie散射信號,研究空化氣泡的半徑變化,定性了解氣泡的動力學特性,并用理論模擬的氣泡半徑-時間曲線和實驗中的Mie散射信號比較。結果表明單泡聲致發(fā)光的周期與換能器驅(qū)動電壓的周期一致,在整個發(fā)光周期中,氣泡在聲場輻射作用下吸收能量緩慢增大,在達到一定程度時在短時間內(nèi)瞬時坍塌減小釋放能量,造成發(fā)光現(xiàn)象的產(chǎn)生。然后從流體的連續(xù)性方程和動量守恒方程出發(fā),推導經(jīng)典的微泡理論模型,并應用范德瓦耳斯絕熱方程對其進行修正,分別對帶球殼微泡和空化氣泡建立模型,模擬它們的運動過程。并在此基礎上,對兩種微泡的散射特性進行了分析與比較,研究了不同驅(qū)動聲場頻
[Abstract]:Ultrasound contrast agent microbubble is a very active field in modern medicine.In the field of ultrasonic diagnosis, the scattering characteristics of microbubbles and the cavitation effect of microbubbles have been widely studied.Based on the sonoluminescence experiments of cavitation bubbles, the kinetic characteristics of microbubbles and cavitation bubbles in spherical shell are calculated and compared theoretically, and the effect of microbubbles acting on biological tissue under single and double frequency ultrasonic transducer is discussed.The ultrasonic characteristics of microbubbles and the effect of microbubbles on biological tissue were studied.First, the Mie scattering signal of single bubble was measured, the radius of cavitation bubble was studied, and the dynamic characteristics of bubble were analyzed qualitatively. The radius-time curve of bubble was compared with the experimental Mie scattering signal.The results show that the period of single bubble sonoluminescence is the same as the period of transducer driving voltage. During the whole period, the absorption energy of bubble increases slowly under the action of sound field radiation.To a certain extent, the transient collapse reduces the releasing energy and causes the luminous phenomenon.Then, based on the continuity equation and momentum conservation equation, the classical theory model of microbubble is deduced, and the van der Waals adiabatic equation is used to modify the model.Simulate their motion.On the basis of this, the scattering characteristics of two kinds of microbubbles are analyzed and compared, and the frequency of sound field driven by two kinds of microbubbles is studied.
【學位授予單位】：上海交通大學
【學位級別】：碩士
【學位授予年份】：2007
【分類號】：R312

【參考文獻】

相關期刊論文 前10條

1 吳巍,寧新寶,姜藻,郭曉遠,馮若;低功率超聲輻射LEVOVIST試劑致家兔肝臟微血管栓塞的研究[J];東南大學學報(自然科學版);2003年03期

2 顧惠瓊;高強度聚焦超聲“切除”腫瘤過程中的空化效應[J];國外醫(yī)學.生物醫(yī)學工程分冊;2003年06期

3 陳立新;造影劑在聲場中的表現(xiàn)形式與聲學造影新技術[J];國外醫(yī)學(生物醫(yī)學工程分冊);2004年03期

4 翟琦;吳巍;;超聲聯(lián)合微泡劑用于腫瘤治療的研究進展[J];醫(yī)學研究生學報;2006年11期

5 錢夢，

本文編號：1729795