本文選題：超聲造影劑　切入點(diǎn)：微泡　出處：《上海交通大學(xué)》2007年碩士論文

【摘要】： 超聲造影劑微泡是現(xiàn)代醫(yī)學(xué)中十分活躍的領(lǐng)域。在超聲診斷領(lǐng)域中利用微泡的散射特性增強(qiáng)超聲成像效果,以及利用微泡的空化效應(yīng)在超聲治療領(lǐng)域的應(yīng)用都得到了相當(dāng)廣泛的研究。 本文從空化氣泡的聲致發(fā)光實(shí)驗(yàn)、理論求解和比較帶球殼微泡和空化氣泡的動(dòng)力學(xué)特性,和微泡在單雙頻超聲換能器下的與生物組織的作用效果出發(fā),研究微泡的超聲特性以及微泡對(duì)生物組織的作用效果。 首先測(cè)量單泡聲致發(fā)光Mie散射信號(hào),研究空化氣泡的半徑變化,定性了解氣泡的動(dòng)力學(xué)特性,并用理論模擬的氣泡半徑-時(shí)間曲線和實(shí)驗(yàn)中的Mie散射信號(hào)比較。結(jié)果表明單泡聲致發(fā)光的周期與換能器驅(qū)動(dòng)電壓的周期一致,在整個(gè)發(fā)光周期中,氣泡在聲場(chǎng)輻射作用下吸收能量緩慢增大,在達(dá)到一定程度時(shí)在短時(shí)間內(nèi)瞬時(shí)坍塌減小釋放能量,造成發(fā)光現(xiàn)象的產(chǎn)生。然后從流體的連續(xù)性方程和動(dòng)量守恒方程出發(fā),推導(dǎo)經(jīng)典的微泡理論模型,并應(yīng)用范德瓦耳斯絕熱方程對(duì)其進(jìn)行修正,分別對(duì)帶球殼微泡和空化氣泡建立模型,模擬它們的運(yùn)動(dòng)過程。并在此基礎(chǔ)上,對(duì)兩種微泡的散射特性進(jìn)行了分析與比較,研究了不同驅(qū)動(dòng)聲場(chǎng)頻
[Abstract]:Ultrasound contrast agent microbubble is a very active field in modern medicine.In the field of ultrasonic diagnosis, the scattering characteristics of microbubbles and the cavitation effect of microbubbles have been widely studied.Based on the sonoluminescence experiments of cavitation bubbles, the kinetic characteristics of microbubbles and cavitation bubbles in spherical shell are calculated and compared theoretically, and the effect of microbubbles acting on biological tissue under single and double frequency ultrasonic transducer is discussed.The ultrasonic characteristics of microbubbles and the effect of microbubbles on biological tissue were studied.First, the Mie scattering signal of single bubble was measured, the radius of cavitation bubble was studied, and the dynamic characteristics of bubble were analyzed qualitatively. The radius-time curve of bubble was compared with the experimental Mie scattering signal.The results show that the period of single bubble sonoluminescence is the same as the period of transducer driving voltage. During the whole period, the absorption energy of bubble increases slowly under the action of sound field radiation.To a certain extent, the transient collapse reduces the releasing energy and causes the luminous phenomenon.Then, based on the continuity equation and momentum conservation equation, the classical theory model of microbubble is deduced, and the van der Waals adiabatic equation is used to modify the model.Simulate their motion.On the basis of this, the scattering characteristics of two kinds of microbubbles are analyzed and compared, and the frequency of sound field driven by two kinds of microbubbles is studied.
【學(xué)位授予單位】：上海交通大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2007
【分類號(hào)】：R312

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本文編號(hào)：1729795