本文關(guān)鍵詞： 致病大腸埃希菌 流行病學(xué) 分子機(jī)制 Ⅲ型分泌系統(tǒng) 研究進(jìn)展　出處：《中國醫(yī)藥導(dǎo)報》2014年12期 　論文類型：期刊論文

【摘要】：腸道大腸埃希菌既是人類正常菌群又是造成全世界發(fā)病和死亡的重要病原體。腸道致病大腸埃希菌傳統(tǒng)上分為6種:腸道致病性大腸埃希菌(EPEC)、腸道出血性大腸埃希菌(EHEC)、腸道侵襲性大腸埃希菌(EIEC)、腸道聚集性大腸埃希菌(EAEC)、腸道產(chǎn)毒素性大腸桿(ETEC)和彌漫黏附大腸埃希菌(DAEC)。本文中提出腸道致病型大腸埃希菌分為8種,還包括2種新的致病型大腸埃希菌———黏附浸潤性大腸埃希菌(AIEC)和產(chǎn)志賀毒素的聚集性大腸埃希菌(STEAEC)。在人類宿主細(xì)胞中,通過檢測腸道大腸埃希菌移植和研究疾病的分子機(jī)制,發(fā)現(xiàn)腸道致病型大腸埃希菌根據(jù)Ⅲ型分泌系統(tǒng)(T3SS),可分為依賴T3SS致病型(EHEC、EPEC、EIEC)和非依賴T3SS致病型(ETEC、EAEC、STEAEC、DAEC、AIEC)2大類。本文主要介紹了腸道致病大腸埃希菌的流行病學(xué)和分子機(jī)制的研究進(jìn)展。
[Abstract]:Escherichia coli is not only a normal human flora, but also an important pathogen of morbidity and mortality in the world. The pathogenic Escherichia coli is traditionally divided into six species: enteropathogenic Escherichia coli (EPECs). Enteric hemorrhagic Escherichia coli (EHEC), enteric invasive Escherichia coli (EIEC), intestinal aggregative Escherichia coli (EAEC). Enterotoxigenic Escherichia coli (ETEC) and diffuse adhesion Escherichia coli (DAEC). In this paper, the pathogenic enteric Escherichia coli is divided into 8 species. It also includes two new pathogenic strains of Escherichia coli---adhesive Escherichia coli AIECs) and Shiga toxin-producing aggregated Escherichia coli STEAECE in human host cells. By detecting the molecular mechanism of intestinal Escherichia coli transplantation and studying the disease mechanism, it was found that the pathogenic Escherichia coli could be classified into T3SS dependent EHEC according to the type 鈪，

本文編號：1463742