本文關(guān)鍵詞：結(jié)核分枝桿菌FurA的基因表達(dá)及單克隆抗體的制備　出處：《第四軍醫(yī)大學(xué)》2005年碩士論文　論文類型：學(xué)位論文

  更多相關(guān)文章： 結(jié)核分枝桿菌 FurA 表達(dá) 單克隆抗體

【摘要】：結(jié)核病(tuberculosis,TB)是由結(jié)核分枝桿菌(Mycobacterium tuberculosis,MTB)所致以呼吸系統(tǒng)感染為主的慢性傳染病。目前全球有1/3的人口感染MTB,每年有800萬新感染患者和300萬患者死亡,占人類致死病因第7位,表明TB仍是影響全球人類健康的一個主要公共衛(wèi)生問題。 MTB在結(jié)核病患者體內(nèi)的生長及致病與很多微量元素有關(guān)。其中,鐵是維持MTB新陳代謝所必需的營養(yǎng)物質(zhì)之一,其作為輔酶或活化劑參與許多與MTB生長密切相關(guān)的氧化還原反應(yīng)。在缺鐵的環(huán)境中,MTB不能生長。然而,鐵與其它營養(yǎng)物質(zhì)不同的是它在中性環(huán)境下溶解度極低,大多數(shù)的鐵與高親和力的鐵蛋白結(jié)合。所以如果結(jié)核病患者血液內(nèi)鐵濃度異常增高可以暗示疾病的惡化。為了對抗機(jī)體的低鐵環(huán)境,MTB可以產(chǎn)生高親和力的鐵鰲合素與機(jī)體鐵蛋白競爭結(jié)合鐵,從而促進(jìn)了結(jié)核病的發(fā)生發(fā)展。 然而,過量的鐵會引起細(xì)胞的毒性作用,不利于MTB的生長。所
[Abstract]:Tuberculosis tuberculosis (TB) is caused by Mycobacterium tuberculosis. At present, 1/3 people worldwide are infected with MTB.At present, 8 million new infections and 3 million deaths occur every year. TB is the seventh leading cause of human death, indicating that TB is still a major public health problem affecting human health worldwide. The growth and pathogenesis of MTB in TB patients are related to many trace elements, among which iron is one of the essential nutrients to maintain the metabolism of MTB. It is involved in many redox reactions closely related to the growth of MTB as a coenzyme or activator. It cannot grow in iron-deficient environment. However. Unlike other nutrients, iron has a very low solubility in neutral environments. Most iron binds to high affinity ferritin. So an abnormal increase in iron levels in the blood of patients with tuberculosis could suggest a worsening of the disease. To combat the body's low iron environment. MTB can produce high affinity iron chelatin to compete with the body ferritin, thus promoting the occurrence and development of tuberculosis. However, excessive iron can cause cytotoxicity, which is not conducive to the growth of MTB.
【學(xué)位授予單位】：第四軍醫(yī)大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2005
【分類號】：R392

【參考文獻(xiàn)】

相關(guān)期刊論文 前2條

1 謝建平,樂軍,王洪海;結(jié)核分枝桿菌的致病機(jī)理[J];生命科學(xué);2002年03期

2 劉宇紅,姜廣路,趙立平,付育紅,李云絮,畢志強(qiáng),王u&民;第四次全國結(jié)核病流行病學(xué)抽樣調(diào)查——結(jié)核分支桿菌耐藥性分析與評價[J];中華結(jié)核和呼吸雜志;2002年04期

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