本文關鍵詞：抗CD137L抗體對小鼠sGVHD和aGVHD的抑制效應rhIL18對小鼠骨髓移植后aGVHD的抑制效應　出處：《山東大學》2006年博士論文　論文類型：學位論文

  更多相關文章： 抗CD137L抗體 Treg細胞 BMT SGVHD aGVHD 白細胞介素18 骨髓移植 移植物抗宿主病

【摘要】：目的 骨髓移植(bone marrow transplantation，BMT)是治療白血病、惡性腫瘤、再生障礙性貧血以及免疫缺陷等疾病的重要手段。根據(jù)骨髓來源的不同，可以將骨髓移植分為自體骨髓移植(autologous BMT)、同基因骨髓移植(syngeneic BMT)、同種異體骨髓移植(allogeneic BMT)。由于自體骨髓移植骨髓來源于自身、同基因骨髓移植的骨髓來自基因型完全相同的個體，臨床上一般無明顯的排斥反應，移植的成功率高，但其缺點是移植后疾病的復發(fā)率高。同種異體骨髓移植的骨髓來自基因型不同的個體，移植后常出現(xiàn)嚴重的并發(fā)癥-移植物抗宿主病(graft versus host disease，GVHD)，使骨髓移植失敗，導致成功率降低，但其優(yōu)點是一旦移植成功，疾病的復發(fā)率低。 臨床研究發(fā)現(xiàn)，同種異體BMT后發(fā)生GVHD的病人白血病復發(fā)率明顯低于病情相似但未發(fā)生GVHD的患者，，動物實驗進一步證明GVHD具有抗白血病作用(graft-versus-leukemia，GVL)，能降低白血病的復發(fā)。根據(jù)這些結(jié)果，人們推測自身或同基因型BMT受者白血病復發(fā)的主要原因之一可能是無GVL作用，因此，如果在自身或同基因型骨髓移植后能誘導適度的GVHD產(chǎn)生GVL將可預防白血病的復發(fā)，提高治療效果。Glazier和Bryson等先后用環(huán)孢素A(CsA)短期治療在同基因型骨髓移植的大鼠和小鼠人工誘導出GVHD樣癥狀，稱同基因型GVHD(syngeneic GVHD，SGVHD)，令人們感興趣的是發(fā)現(xiàn)SGVHD同樣具有抗白血病作用。目前，自身骨髓移植
[Abstract]:objective
Bone marrow transplantation (bone marrow transplantation, BMT) is the treatment of leukemia, malignant tumor, an important means of aplastic anemia and immunodeficient diseases. According to the different source of bone marrow, bone marrow transplantation can be divided into autologous bone marrow transplantation (autologous BMT), with the base for bone marrow transplantation (syngeneic BMT), allogeneic bone marrow transplantation (allogeneic BMT). The autologous bone marrow transplantation of bone marrow from their own, syngeneic bone marrow transplantation of bone marrow from genetically identical individuals, clinically no obvious rejection reaction, transplanted into high power, but its disadvantage is the disease with high recurrence rate after transplantation. Allogeneic bone marrow transplantation of bone marrow from different genotypes individuals often appear serious complications after transplantation and graft-versus-host disease (graft versus host disease, GVHD), the bone marrow transplant failure, resulting in lower success rate, but its advantage is a The relapse rate of the disease is low.
The clinical study found that the occurrence of GVHD after allogeneic BMT patients relapse rate was significantly lower than that in similar conditions but without GVHD patients, the animal experiments prove that GVHD has the effect of anti leukemia (graft-versus-leukemia, GVL), can reduce the recurrence of leukemia. According to these results, people speculate itself or the same genotype BMT by one of the main causes of recurrence leukemia may be no GVL effect, therefore, if can induce moderate GVHD GVL will prevent the relapse of leukemia after autologous bone marrow transplantation, improve the therapeutic effect of.Glazier and Bryson successively with cyclosporine A (CsA) artificial short-term treatment induce GVHD like symptoms in syngeneic bone marrow transplantation rats and mice, that same genotype GVHD (syngeneic GVHD SGVHD), who is interested in discovering SGVHD also has anti leukemia effect. At present, autologous bone marrow transplantation

【學位授予單位】：山東大學
【學位級別】：博士
【學位授予年份】：2006
【分類號】：R392

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相關期刊論文 前2條

1 居小萍,王健民,侯軍,馮曹波,童書鵬,章衛(wèi)平;白細胞介素-18在急性移植物抗宿主病發(fā)病機制中的作用[J];中國實驗血液學雜志;2002年05期

2 張利寧,曹英林,趙文璞,馬春紅,宋靜,孫汶生;CD137在SLE和RA病人外周血T細胞上的表達特點及意義[J];中華微生物學和免疫學雜志;2000年02期

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