發(fā)布時間：2018-01-12 14:00

  本文關(guān)鍵詞：WONCA研究論文摘要匯編——癌癥診斷對自殺及心血管疾病死亡發(fā)生率的影響　出處：《中國全科醫(yī)學(xué)》2013年11期 　論文類型：期刊論文

  更多相關(guān)文章： WONCA 研究論文 摘要 匯編 癌癥 診斷 自殺 血管疾病 死亡 發(fā)生率 影響

【摘要】：背景收到癌癥診斷對患者來講是一種創(chuàng)傷性經(jīng)歷,其直接導(dǎo)致的不良健康后果可超過疾病或治療產(chǎn)生的影響。方法我們利用泊松及負(fù)二項回歸模型,進(jìn)行一項含有6 073 240例瑞典人的歷史性隊列研究,以探究癌癥診斷與1991—2006年期間自殺或心血管疾病死亡直接風(fēng)險的關(guān)系。為了校正無法測定的混雜因素,對隊列中因自殺或心血管疾病死亡的癌癥患者進(jìn)行巢式、自我匹配的病例交叉分析。結(jié)果與未患癌癥的受試者相比,收到癌癥診斷的患者在第1周內(nèi)的自殺相對風(fēng)險為12.6,95%CI(8.6,17.8)(29例患者,發(fā)生率為2.5例/1 000人年);第1年內(nèi)為3.1,95%CI(2.7,3.5)(260例患者,發(fā)生率為0.6例/1 000人年)。診斷后第1周內(nèi)的心血管疾病死亡相對風(fēng)險為5.6,95%CI(5.2,5.9)(1 318例患者,發(fā)生率為116.80例/1 000人年);前4周內(nèi)為3.3,95%CI(3.1,3.4)(2 641例患者,發(fā)生率為65.81例/1 000人年)。診斷后第1年內(nèi),升高的風(fēng)險迅速降低。對于預(yù)后不良的癌癥,風(fēng)險的增加尤其明顯。病例交叉分析很大程度上證實了先前主要分析得出的結(jié)果。結(jié)論本次大規(guī)模隊列研究中,新近收到癌癥診斷的患者與未患癌癥的受試者相比,自殺及心血管疾病死亡風(fēng)險均有所增加。
[Abstract]:Background receipt of cancer diagnosis was a traumatic experience for patients with a direct result of adverse health consequences beyond the effects of disease or treatment . Methods We performed a historical cohort study of 6 073 240 Swedes using Poisson and negative binomial regression models to investigate cancer diagnosis with a nested , self - matched case cross - analysis for cancer patients who died of suicide or cardiovascular disease during the first week ( 29 patients , 2.5 / 1,000 years ) ; and 3.1 , 95 % CI ( 2.7 , 3.5 ) in the first year ( 260 patients with an incidence of 0.6 / 1,000 ) . The relative risk of cardiovascular disease deaths within the first week after diagnosis was 5.6 , 95 % CI ( 5.2 , 5.9 ) ( 1,318 patients , incidence rate 116 . 80 / 1,000 person years ) ; 3.3 , 95 % CI ( 3.1 , 3.4 ) in the first 4 weeks ( 2,641 patients , incidence : 65.81 / 1,000 person years ) . The increased risk was rapidly reduced within the first year of diagnosis . The increased risk was particularly evident for poor prognosis . The case - crossover analysis largely confirmed the results of the previous primary analysis . Conclusion In this large cohort study , there has been an increase in the risk of suicide and cardiovascular death in patients with newly received cancer diagnosis compared to those without cancer .

【作者單位】： 中國石油天然氣集團(tuán)公司中心醫(yī)院;
【分類號】：R730.4
【正文快照】： 原文見:Fang F,Fall K,Mittleman MA,et al.Suicide and cardiovascular death after a cancer diagnosis[J].N Engl J Med,2012,366(3):1310-1318.published at http://www.nejm.org/doi/full/10.1056/NEJMoa1110307.WONCA研究論文摘要匯編——癌癥診斷對自殺及心血管疾病死，

本文編號：1414538