近年來(lái),土壤線蟲(chóng)危害日趨嚴(yán)重,然而市場(chǎng)上應(yīng)用的殺線蟲(chóng)劑品種匱乏且結(jié)構(gòu)單一。氟吡菌酰胺（fuopyram）是德國(guó)拜耳公司開(kāi)發(fā)的琥珀酸脫氫酶抑制劑（SDHI）類(lèi)殺菌劑,因其高效和作用機(jī)制新穎被廣泛用于土壤線蟲(chóng)的防治。本文以殺菌、殺線蟲(chóng)劑氟吡菌酰胺為分子骨架,通過(guò)引入硫醚和砜亞結(jié)構(gòu),設(shè)計(jì)合成了兩個(gè)系列的結(jié)構(gòu)新穎的目標(biāo)化合物,并經(jīng)核磁共振氫譜（¹H NMR）、核磁共振碳譜(¹³C NMR)和高分辨質(zhì)譜（HRMS）表征新結(jié)構(gòu)。經(jīng)生物活性測(cè)試發(fā)現(xiàn),與對(duì)照藥氟吡菌酰胺相比,大多數(shù)目標(biāo)化合物在200μg·mL^–1濃度下顯示出優(yōu)異的殺線蟲(chóng)活性,而當(dāng)濃度降低為100μg·mL^–1時(shí),線蟲(chóng)死亡率大大降低,其中,化合物Ⅰ-11、Ⅱ-6除外。在殺菌活性方面,化合物Ⅰ-9具有優(yōu)異的抑菌率,其分子對(duì)接結(jié)果將為高活性殺菌先導(dǎo)化合物的設(shè)計(jì)和探索提供重要的理論指導(dǎo)。 

【文章來(lái)源】：Engineering. 2020,6(05)EISCI

【文章頁(yè)數(shù)】：14 頁(yè)

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