代謝組學研究的文獻計量分析
發(fā)布時間：2018-08-18 16:43
【摘要】：目的:了解國內(nèi)外代謝組學的研究現(xiàn)狀,初步探討其研究熱點及發(fā)展規(guī)律。方法:采用文獻計量方法,借助Go Pub Med文獻分析工具,以"Metabolomics"為主題詞,檢索Pub Med數(shù)據(jù)庫截至2016年7月31日的所有文獻,對相關文獻按發(fā)文量、國家和城市、期刊來源、研究主題、核心作者和作者合作網(wǎng)絡等信息進行排名并分析。以"Metabolomics""Metabonomics"為主題詞,檢索Web of Science數(shù)據(jù)庫截至2016年8月1日的所有文獻,利用其被引頻次排序功能,分析2007-2016年被引頻次較高的文獻。結(jié)果:共檢索得到國內(nèi)外代謝組學相關文獻15 449篇,其中我國研究者發(fā)表2 189篇,發(fā)文量總體均呈上升趨勢。15 449篇文獻分布于全球129個國家和地區(qū),美國、中國、英國、德國等10個國家為核心發(fā)文國家,發(fā)文總量為12 847篇(占83.16%);發(fā)文量最多的國家是美國(4 288篇,占27.76%),其次為中國(2 189篇,占14.17%);發(fā)文量最多的城市是倫敦(467篇),上海和北京分列第2、3位。文獻共涉及期刊2 168種,刊均載文量為7.1篇;發(fā)文量最多的20種期刊均來自于歐美國家(4 377篇,占28.33%)。出現(xiàn)頻次最高的前3個主題詞分別為代謝組學、代謝組和代謝,相關研究主要集中在代謝過程、代謝通路、生物標志物、蛋白質(zhì)組和基因組等方面,研究方法主要包括質(zhì)譜法和磁共振波譜法。主要涉及6個作者群,以Nicholoson JK、Holmes E、Lindon JC等研究者為主;核心作者及作者群中未見我國研究者。高被引文獻主要涉及代謝與疾病的相關性、代謝組學數(shù)據(jù)庫簡介、代謝組學研究方法及與疾病預測有關的生物標志物等內(nèi)容。結(jié)論:代謝組學引起了世界范圍內(nèi)研究者的廣泛興趣,其中代謝通路和生物標志物是該領域的研究熱點之一。我國研究者在代謝組學方面的總發(fā)文量較多,但缺乏高質(zhì)量的期刊載體,且研究者之間的合作較少。我國應鼓勵各研究機構(gòu)間的交流合作,緊緊把握該領域研究的前沿與熱點,促進我國代謝組學研究的多元化和深層次化。
[Abstract]:Objective: to understand the current research situation of metabolomics at home and abroad, and to discuss its research hotspot and development law. Methods: with the help of Go Pub Med literature analysis tool and "Metabolomics" as the subject word, all the documents in the Pub Med database were searched by literature metrology method, and the relevant documents were collected according to the quantity of papers, country, city and periodical sources. Research topics, core author and author collaboration network information ranking and analysis. Taking "Metabolomics" Metabonomics "as the theme word, all the documents in Web of Science database as of Aug. 1, 2016 were searched, and the documents with higher citation frequency from 2007 to 2016 were analyzed by using its citation frequency sorting function. Results: a total of 15,449 literatures on metabolomics were retrieved, of which 2,189 were published by Chinese researchers. The total number of published articles was on the rise. 15,449 papers were distributed in 129 countries and regions, including the United States, China, Britain, the United States of America, China, Britain, the United States of America, China and the United Kingdom. Germany and other 10 countries are the core sending countries, with a total of 12,847 (83.16%), the United States (4,288, 27.76%) and China (2,189), the United States (4,288) and China (27.76%). London (467 articles) and Shanghai and Beijing ranked second and third respectively. A total of 2,168 kinds of periodicals were involved, with 7.1 articles published per journal, and the 20 journals with the largest number of publications were from Europe and America (4,377 articles, 28.33%). The first three subject words with the highest frequency are metabonomics, metabolic group and metabolism. The related studies mainly focus on metabolic process, metabolic pathway, biomarkers, proteome and genome, etc. The main research methods include mass spectrometry and magnetic resonance spectroscopy. Six author groups are mainly involved, such as Nicholoson JK Holmes EN Lindon JC and so on, but no Chinese researchers have been found among the core authors and authors. The highly cited literature is mainly concerned with the correlation between metabolism and disease, the introduction of metabolomics database, the research methods of metabonomics and the biomarkers related to disease prediction and so on. Conclusion: metabolic pathways and biomarkers have attracted worldwide interest. In China, the total number of papers published in metabonomics is relatively large, but there is a lack of high-quality journal carriers, and there is less cooperation among researchers. Our country should encourage the exchange and cooperation among the research institutions, grasp the frontier and hot spot of the research in this field, and promote the diversification and deep level of the research on metabolomics in China.
【作者單位】： 河北醫(yī)科大學研究生學院;河北省人民醫(yī)院藥學部;
【分類號】：G353.1;Q591
本文編號：2190065
[Abstract]:Objective: to understand the current research situation of metabolomics at home and abroad, and to discuss its research hotspot and development law. Methods: with the help of Go Pub Med literature analysis tool and "Metabolomics" as the subject word, all the documents in the Pub Med database were searched by literature metrology method, and the relevant documents were collected according to the quantity of papers, country, city and periodical sources. Research topics, core author and author collaboration network information ranking and analysis. Taking "Metabolomics" Metabonomics "as the theme word, all the documents in Web of Science database as of Aug. 1, 2016 were searched, and the documents with higher citation frequency from 2007 to 2016 were analyzed by using its citation frequency sorting function. Results: a total of 15,449 literatures on metabolomics were retrieved, of which 2,189 were published by Chinese researchers. The total number of published articles was on the rise. 15,449 papers were distributed in 129 countries and regions, including the United States, China, Britain, the United States of America, China, Britain, the United States of America, China and the United Kingdom. Germany and other 10 countries are the core sending countries, with a total of 12,847 (83.16%), the United States (4,288, 27.76%) and China (2,189), the United States (4,288) and China (27.76%). London (467 articles) and Shanghai and Beijing ranked second and third respectively. A total of 2,168 kinds of periodicals were involved, with 7.1 articles published per journal, and the 20 journals with the largest number of publications were from Europe and America (4,377 articles, 28.33%). The first three subject words with the highest frequency are metabonomics, metabolic group and metabolism. The related studies mainly focus on metabolic process, metabolic pathway, biomarkers, proteome and genome, etc. The main research methods include mass spectrometry and magnetic resonance spectroscopy. Six author groups are mainly involved, such as Nicholoson JK Holmes EN Lindon JC and so on, but no Chinese researchers have been found among the core authors and authors. The highly cited literature is mainly concerned with the correlation between metabolism and disease, the introduction of metabolomics database, the research methods of metabonomics and the biomarkers related to disease prediction and so on. Conclusion: metabolic pathways and biomarkers have attracted worldwide interest. In China, the total number of papers published in metabonomics is relatively large, but there is a lack of high-quality journal carriers, and there is less cooperation among researchers. Our country should encourage the exchange and cooperation among the research institutions, grasp the frontier and hot spot of the research in this field, and promote the diversification and deep level of the research on metabolomics in China.
【作者單位】： 河北醫(yī)科大學研究生學院;河北省人民醫(yī)院藥學部;
【分類號】：G353.1;Q591
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