發(fā)布時(shí)間：2019-07-04 14:50

【摘要】：目的:分析冠心病阿司匹林抵抗(Aspirinresistance,AR)的患病率、相關(guān)危險(xiǎn)因素及中醫(yī)證素分布情況,為防治阿司匹林抵抗提供依據(jù)。方法:選取服用阿司匹林(1OOmg/晚)至少4周的經(jīng)造影證實(shí)的冠心病患者100例,平均年齡68.95±8.91歲。根據(jù)花生四烯酸AA(1mmol/L)誘導(dǎo)的血小板聚集實(shí)驗(yàn)結(jié)果分為三組:血小板聚集率≥80%為阿司匹林抵抗,聚集率≥50%且80%為阿司匹林半抵抗(Aspirin semiresistance,ASR),聚集率50%為阿司匹林敏感(Aspirin sensitive,AS),并以文獻(xiàn)資料研究、專家咨詢?yōu)榛A(chǔ),對每位患者的中醫(yī)證素類型(主要為氣虛、痰濁、血瘀、氣滯、陽虛、陰虛、寒凝7種)進(jìn)行判定,比較三組的相關(guān)危險(xiǎn)因素及中醫(yī)證素分布。結(jié)果:冠心病患者中阿司匹林抵抗12例,阿司匹林抵抗組空腹血糖、肌酐、冠脈病變血管數(shù)及嚴(yán)重病變數(shù)較其他組高(P0.05),餐后2h胰島素水平較其他組低(P0.05)。三組中醫(yī)證素分布比較無統(tǒng)計(jì)學(xué)差異(P0.05)。二元回歸分析顯示空腹血糖水平是阿司匹林抵抗的危險(xiǎn)因素。結(jié)論:冠心病阿司匹林抵抗具有較高發(fā)生率,空腹血糖水平與阿司匹林抵抗具有密切相關(guān)性,阿司匹林抵抗組虛證主要證素為氣虛、陰虛,實(shí)證主要證素為血瘀、痰濁,阿司匹林敏感性不影響中醫(yī)證素分布情況。
[Abstract]:Objective: to analyze the prevalence, risk factors and distribution of TCM syndromes of aspirin resistance (Aspirinresistance,AR) in coronary heart disease (CAD), so as to provide evidence for the prevention and treatment of aspirin resistance. Methods: 100 patients with coronary heart disease confirmed by radiography with aspirin (1OOmg/) for at least 4 weeks were selected, with an average age of 68.95 鹵8.91 years. According to the results of platelet aggregation induced by arachidonic acid AA (1mmol/L), the platelet aggregation rate 鈮，

本文編號：2509998