【摘要】：目的:探討烏魯木齊部分地區(qū)碘營養(yǎng)狀態(tài)與甲狀腺癌的關(guān)系。方法:選取2014年3月-2014年12月在新疆醫(yī)科大學(xué)第一附屬醫(yī)院血管甲狀腺外科行手術(shù)治療并經(jīng)病理證實(shí)的甲狀腺良性結(jié)節(jié)患者158例為甲狀腺良性結(jié)節(jié)組、甲狀腺癌患者156例為甲狀腺癌組,及同期在新疆醫(yī)科大學(xué)第二附屬醫(yī)院體檢中心行甲狀腺超聲提示甲狀腺形態(tài)正常者301例為甲狀腺形態(tài)正常組。記錄三組一般資料、尿碘及血清甲狀腺功能、甲狀腺自身抗體表達(dá)水平,并進(jìn)行比較分析。甲狀腺癌危險(xiǎn)因素分析采用多因素Logistic回歸分析。結(jié)果:三組性別、年齡間差異有統(tǒng)計(jì)學(xué)意義(P0.05);而民族間差異無統(tǒng)計(jì)學(xué)意義(P0.05)。三組血清總?cè)饧紫僭彼?TT _3)、總甲狀腺素(TT4)、促甲狀腺激素(TSH)、甲狀腺球蛋白抗體(TgAb)、甲狀腺過氧化物酶抗體(TPOAb)水平間差異均有統(tǒng)計(jì)學(xué)意義(P0.05)。615例受試者尿碘中位數(shù)為[261.50(221.50)]μg/L,其中甲狀腺形態(tài)正常組為[257.60(169.35)]μg/L,甲狀腺良性結(jié)節(jié)組為[261.05(263.42)]μg/L,甲狀腺癌組為[297.90(374.40)]μg/L,三組間差異有統(tǒng)計(jì)學(xué)意義(P0.05);其中甲狀腺癌組與甲狀腺良性結(jié)節(jié)組、甲狀腺形態(tài)正常組比較,甲狀腺良性結(jié)節(jié)組與甲狀腺形態(tài)正常組比較,差異均有統(tǒng)計(jì)學(xué)意義(P0.05)。多因素Logistic回歸分析結(jié)果顯示,碘過量、女性、血清TgAb異常是甲狀腺癌的危險(xiǎn)因素(P0.05)。結(jié)論:烏魯木齊地區(qū)人群碘缺乏狀態(tài)已糾正,并處于超適宜量水平,碘過量、女性、血清TgAb異常是甲狀腺癌的危險(xiǎn)因素,建議該地區(qū)人群飲食上控制含碘食物及碘鹽的攝入。
[Abstract]:Objective: to investigate the relationship between iodine nutritional status and thyroid carcinoma in Urumqi. Methods: from March 2014 to December 2014, 158 patients with benign thyroid nodule were selected as thyroid benign nodule group, who were treated surgically and pathologically in the first affiliated Hospital of Xinjiang Medical University. 156 patients with thyroid cancer were diagnosed as thyroid carcinoma, and 301 patients with normal thyroid morphology were examined by thyroid ultrasound in the physical examination center of the second affiliated Hospital of Xinjiang Medical University. The general data of the three groups, urine iodine, serum thyroid function and thyroid autoantibody expression were recorded and compared. Multivariate Logistic regression analysis was used to analyze the risk factors of thyroid cancer. Results: there were significant differences in sex and age among the three groups (P0.05), but there was no significant difference among ethnic groups (P0.05). The levels of serum total triiodothyronine (TT _ 3), total thyroxine (TT4), thyroid stimulating hormone (TSH),) thyroglobulin antibody (TgAb),) thyroid peroxidase antibody (TPOAb) were significantly different among the three groups (P0.05). [261.50 (221.50)] 渭 g / L, including [257.60 (169.35) 渭 g / L, [261.05 (263.42) 渭 g / L, [297.90 (374.40)] 渭 g / L, in thyroid benign nodule group and thyroid carcinoma group, respectively (P0.05). The comparison of normal thyroid morphology group, thyroid benign nodule group and thyroid shape normal group, the difference was statistically significant (P0.05). Multivariate Logistic regression analysis showed that iodine overdose, female and serum TgAb abnormality were risk factors of thyroid carcinoma (P0.05). Conclusion: iodine deficiency status has been corrected in Urumqi area, and it is at the level of overdose. Iodine excess, female and serum TgAb abnormality are the risk factors of thyroid cancer. It is suggested that the intake of iodized food and iodized salt should be controlled in the diet of the population in Urumqi.
【學(xué)位授予單位】：新疆醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：R736.1

【參考文獻(xiàn)】

相關(guān)期刊論文 前10條

1 陳翠霞;羅錚錚;侯文群;楊燕珍;楊小敏;;甲狀腺結(jié)節(jié)性疾病與碘營養(yǎng)水平關(guān)系的臨床研究[J];川北醫(yī)學(xué)院學(xué)報(bào);2016年06期

2 白超;魏巍;張麗;楊雯雯;黃婷;;烏魯木齊地區(qū)人群碘和硒營養(yǎng)狀態(tài)與甲狀腺癌相關(guān)性研究[J];新疆醫(yī)科大學(xué)學(xué)報(bào);2016年09期

3 李興佳;徐書杭;劉超;;雌激素及其受體與甲狀腺癌的關(guān)系[J];國際內(nèi)分泌代謝雜志;2016年04期

4 陳志丹;陳德杰;程瑾;;甲狀腺癌相關(guān)危險(xiǎn)因素分析[J];中國腫瘤;2016年06期

5 張虹;陳建華;魏巍;張麗;;烏魯木齊甲狀腺癌相關(guān)危險(xiǎn)因素調(diào)查研究[J];中國全科醫(yī)學(xué);2016年12期

6 張紹東;陳文才;王曉燕;;甲狀腺癌相關(guān)危險(xiǎn)因素的病例對(duì)照研究[J];現(xiàn)代實(shí)用醫(yī)學(xué);2016年02期

7 武大勝;閆萍;劉俊平;;2010-2014年張家口市市級(jí)碘缺乏病病情監(jiān)測(cè)數(shù)據(jù)分析[J];中國地方病防治雜志;2016年01期

8 陳冰;張帆;陶香香;朱曉群;何雷;;甲狀腺癌540例臨床病理構(gòu)成分析[J];山西醫(yī)科大學(xué)學(xué)報(bào);2014年08期

9 楊雷;鄭榮壽;王寧;張思維;陳萬青;;2010年中國甲狀腺癌發(fā)病與死亡情況[J];中華預(yù)防醫(yī)學(xué)雜志;2014年08期

10 姚姣;曹仁賢;文芳;;雌激素作為甲狀腺癌治療靶點(diǎn)的研究進(jìn)展[J];現(xiàn)代醫(yī)藥衛(wèi)生;2014年01期

，

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