【摘要】：目的:正畸過程中普遍存在釉質脫礦現(xiàn)象,釉質脫礦不僅造成釉質白斑,影響美觀,而且隨脫礦加重會形成早期齲。多種治療制劑已被應用于臨床,近年來也有大量相關研究,但研究對象多局限于兩種制劑、缺乏對不同原理制劑的系統(tǒng)比較;研究內(nèi)容多集中于治療效果,對作用的時效性、持續(xù)性等特點的研究較少。研究對象和內(nèi)容的局限性,使各種制劑間可比性下降,影響了對臨床治療的參考價值。因此,本實驗選取了不同作用原理的常見有效制劑進行比較,并選取三個時間點,對滲透樹脂、含氟制劑、GC護牙素治療效果進行定性及定量檢測,將不同制劑作用時效性、持續(xù)性及治療效果進行了對比,旨在為臨床治療提供參考依據(jù)。材料與方法:1.材料準備:收集50顆前磨牙隨機均勻分組,設置A組為對照組,B、C、D、E為實驗組。2.建立脫礦模型:樣品浸于人工脫礦液中,37 ℃,2周,脫礦液每日更換。3.治療制劑處理:A組人工唾液處理,B組ClinproTM White Varnish處理,C組ClinproTM XT Varnish處理,D組GC護牙素處理,E組Icon滲透樹脂處理。均置入人工唾液中6周,每日更換人工唾液。4.肉眼觀察脫礦前后及治療前后釉質表面顏色和平滑度變化。5.治療2周末、4周末、6周末利用顯微硬度計測定表面顯微硬度,利用SPSS 17軟件對顯微硬度值進行統(tǒng)計對比。6.治療6周后,利用掃描電鏡(SU8010)觀察釉質表面形態(tài)。結果:1.肉眼觀察:(1)釉質脫礦后各組均呈現(xiàn)明顯的白堊色外觀、表面粗糙;(2)不同制劑處理后,各組差異顯著,A組釉質表面色澤和粗糙度輕微改善,再礦化效果D組B組C組,E組處理后,釉質脫礦即刻改善,效果最明顯。2.顯微硬度值比較:(1)組間對比表明,處理2周后,除B、C組無統(tǒng)計學差異外(p0.05),其余各組差異顯著(p0.01),治療4、6周,各組間均具有顯著差異(p0.01);(2)組內(nèi)對比表明,A組第2、第4周間無統(tǒng)計學差異(p0.05),其余各組差異顯著(p0.01),B組第4、6周無差異(p0.05),其余差異顯著(p0.01),C、D組三個時間點均差異顯著(p0.01),E組三個時間點均無統(tǒng)計學差異(p0.05)。3.掃描電鏡觀察:(1)A組表面不平滑,少量沉積物分布,脫礦間隙較大,釉質末端有溶解和破壞;(2)B組表面不平滑,以小顆粒沉積物為主,脫礦間隙不明顯,釉質末端被沉積顆粒覆蓋;(3)C組表面不平滑,沉積顆粒較小,脫礦間隙不明顯,少量釉質末端可見;(4)D組表面較平滑,沉積顆粒較小,無明顯脫礦間隙,釉質末端較完整;(5)E組釉質表面較平滑,無明顯脫礦間隙,可見緊密排列的桿狀樹脂突。結論:1.作用的時效性:人工唾液最緩慢;含氟試劑前兩周作用緩慢,四周后明顯;GC護牙素早期即作用明顯;Icon滲透樹脂可即刻恢復釉質表面色澤和形態(tài);治療時效性為Icon滲透樹脂GC護牙素ClinproTM XT VarnishClinproTM White Varnish人工唾液。2.作用的持續(xù)性:人工唾液再礦化作用隨時間輕度增加;4周后ClinproTM White Varnish再礦化作用不明顯;ClinproTM XT Varnish和GC護牙素再礦化作用持續(xù)時間長;Icon滲透樹脂即刻完成治療且效果穩(wěn)定。3.最終治療效果:結合肉眼觀察、掃描電鏡、顯微硬度,各種制劑治療早期釉質脫礦的效果依次為Icon滲透樹脂GC護牙素ClinproTM XT VarnishClinproTM White Varnish人工唾液。
[Abstract]:Objective: enamel demineralization is common in orthodontic process. Enamel demineralization not only causes enamel leukoplakia, but also causes early decayed enamel. A variety of treatment preparations have been applied to clinical and many related studies have been applied in recent years, but the research object is limited to two kinds of preparations and lack of systematic comparison of different principles. The research content concentrates on the effect of treatment, the research on the effect of timeliness, persistence and other characteristics is less. The limitations of the research object and content make the comparability between various preparations decrease and affect the reference value of the clinical treatment. Therefore, this experiment selects the common effective preparations of different action pros and choose three times. The effect of osmotic resin, fluorine containing preparation and GC in the treatment of dentin was measured qualitatively and quantitatively. The effect of aging, persistence and treatment of different preparations were compared. The purpose was to provide reference basis for clinical treatment. Materials and methods: 1. material preparation: collect 50 premolars randomly and evenly group, set A group as control group, B, C, D, E The demineralization model was established for the experimental group.2.: the samples were immersed in the artificial demineralization solution, 37 and 2 weeks, and the demineralized solution was changed daily for the treatment of.3. treatment preparations: group A artificial saliva treatment, group B ClinproTM White Varnish treatment, C group ClinproTM XT Varnish treatment, D group dentin treatment and infiltration resin treatment. They were all placed in artificial saliva for 6 weeks, daily replacement. Artificial saliva.4. eyes before and after demineralization and before and after demineralization and before and after the treatment of enamel surface color and skid change.5. treatment 2 weekend, 4 weekend, the 6 weekend, the use of microhardness tester to determine the surface microhardness, the use of SPSS 17 software to compare the microhardness value of the microhardness values for 6 weeks after the.6. treatment, using scanning electron microscopy (SU8010) to observe the surface morphology of enamel. Results: 1 Naked eye observation: (1) after enamel demineralization, all groups showed obvious Cretaceous appearance and rough surface; (2) after the treatment of the different preparations, the differences were significant, the color and roughness of the enamel surface of group A was slightly improved, the remineralization effect of group D B group C, after E group treatment, the enamel demineralization immediately improved, the effect of the most obvious.2. microhardness was compared: (1) comparison among groups The results showed that after 2 weeks of treatment, there was no statistical difference in group C except B (P0.05), and the difference between the other groups was significant (P0.01), and there was significant difference between each group (P0.01). (2) there was no statistical difference between second and fourth weeks in group A (P0.05), and there was a significant difference between the other groups (P0.01), and there was no difference in 4,6 week (P0.05) in the B group. The rest of the difference was significant. The three time points of group D were significantly different (P0.01), and there was no statistical difference between the three time points of group E (P0.05).3. scanning electron microscope: (1) the surface of A group was not smooth, a small amount of sediment was distributed, the demineralization gap was larger, the end of the enamel was dissolved and destroyed; (2) the surface of the B group was not smooth, and the deposit gap was not obvious and the end of the enamel was sunk. (3) the surface of the C group is not smooth, the deposition particles are smaller, the demineralization gap is not obvious, the end of a small amount of enamel is visible; (4) the surface of the group of D is smooth, the deposition particles are smaller, there is no clear demineralization gap, the end of the enamel is more complete; (5) the enamel surface of group E is smooth, there is no obvious demineralization gap, and the close arrangement of rod form resin process can be seen. Conclusion: 1. effect. Timeliness: artificial saliva is the slowest; fluorine containing reagent is slow in two weeks and obvious after four weeks; GC amidin is obvious in the early stage; Icon permeation resin can instantly restore the color and shape of enamel surface; the therapeutic timeliness is the continuity of the role of Icon osmosis resin GC amidin ClinproTM XT VarnishClinproTM White Varnish artificial saliva.2.. The effect of the remineralization of the saliva was slightly increased with time, and the remineralization of ClinproTM White Varnish was not obvious after 4 weeks; the remineralization of ClinproTM XT Varnish and GC was prolonged for a long time; Icon osmosis resin immediately completed the treatment and the effect was stable.3. final treatment effect: combined with meat eye observation, scanning electron microscope, microhardness, and the treatment of various preparations. The effect of early enamel demineralization was Icon osmotic resin GC, dentin ClinproTM XT VarnishClinproTM White Varnish artificial saliva.
【學位授予單位】：山東大學
【學位級別】：碩士
【學位授予年份】：2017
【分類號】：R783.5

【參考文獻】

相關期刊論文 前10條

1 楊紅麗;唐睿;黃珊珊;楊雁;;滲透樹脂治療固定矯治后前牙唇面白堊斑的臨床觀察[J];臨床口腔醫(yī)學雜志;2016年03期

2 沈強;;口腔正畸固定矯治器應用中牙釉質脫礦的臨床探討[J];中外醫(yī)學研究;2015年17期

3 楊珍;;正畸治療中預防牙釉質脫礦的方法研究[J];臨床合理用藥雜志;2015年03期

4 劉建華;宋寧;李曉峰;周鑄明;廖志清;;兩種滲透樹脂早期釉質齲滲透性的比較研究[J];廣東牙病防治;2013年08期

5 劉永紅;葛立宏;陳慧珍;池學謙;;滲透樹脂在自然形成的早期齲損中滲透能力的研究[J];華西口腔醫(yī)學雜志;2012年05期

6 唐璐;楊四維;;CPP-ACP在預防正畸釉質脫礦中的應用[J];中國社區(qū)醫(yī)師(醫(yī)學專業(yè));2012年12期

7 張榮德;;滲透樹脂治療平滑面早期齲的臨床觀察[J];甘肅醫(yī)藥;2012年04期

8 方萍;周嫣;陳燕;黎石堅;韋藝;羅菊芬;;口腔綜合防治措施對固定矯治患者菌斑指數(shù)的影響[J];中國美容醫(yī)學;2012年01期

9 張豐偉;賈智;趙夢明;劉大勇;;滲透型樹脂治療釉質齲顏色穩(wěn)定性的短期研究[J];天津醫(yī)科大學學報;2011年02期

10 付娟;董青;王琳;;氟保護漆應用的研究進展[J];當代醫(yī)學;2011年08期

相關碩士學位論文 前2條

1 張春波;CPP-ACP與含氟制劑抑制牙釉質脫礦的比較研究[D];吉林大學;2012年

2 許音;不同類型保持器對固定矯治后牙釉質脫礦再礦化的影響[D];河北醫(yī)科大學;2012年

，

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