本文選題：中藥外敷 + 良性單純性甲狀腺結(jié)節(jié)��； 參考：《黑龍江中醫(yī)藥大學(xué)》2017年碩士論文

【摘要】：目的:觀察中藥外敷治療良性單純性甲狀腺結(jié)節(jié)(肝郁痰凝血瘀型)的臨床療效,研究該膏藥方對(duì)良性單純性甲狀腺結(jié)節(jié)的影響,以及該膏藥方的有效性和安全性,并對(duì)本次研究?jī)?nèi)容及數(shù)據(jù)結(jié)果進(jìn)行總結(jié)和分析后進(jìn)一步規(guī)范中藥外敷的技術(shù)操作方法,以期找到一種有效、安全、規(guī)范、便于臨床操作的中醫(yī)外治本病的方法。方法:此次研究采用的是隨機(jī)對(duì)照方法,將符合良性單純性甲狀腺結(jié)節(jié)(肝郁痰凝血瘀型)診斷標(biāo)準(zhǔn)的60例患者隨機(jī)分為兩組,治療組予以中藥外敷聯(lián)合口服夏枯草顆粒,對(duì)照組為口服夏枯草顆粒,觀察12周。12周后進(jìn)行臨床療效評(píng)價(jià),評(píng)估治療前后兩組患者臨床癥狀和體征的變化,以及相關(guān)指標(biāo)的變化,包括甲狀腺最大結(jié)節(jié)直徑、甲狀腺功能、肝腎功能、血常規(guī)、安全性指標(biāo)、中醫(yī)癥候積分以及療效評(píng)分,并做記錄。對(duì)照治療前后是否改善、好轉(zhuǎn)還是沒(méi)有變化,對(duì)實(shí)驗(yàn)結(jié)果進(jìn)行統(tǒng)計(jì)學(xué)分析。本次觀察全部數(shù)據(jù)采用SPSS 17.0軟件進(jìn)行統(tǒng)計(jì)學(xué)分析。結(jié)果:符合納入標(biāo)準(zhǔn)的患者,治療前兩組患者的性別、年齡、病程、甲狀腺結(jié)節(jié)的最大結(jié)節(jié)直徑等無(wú)顯著性差異(P0.05),說(shuō)明兩組數(shù)據(jù)具有可比性。在總的有效率、中醫(yī)癥狀療效、中醫(yī)癥狀積分、甲狀腺結(jié)節(jié)縮小程度等方面,存在著差異(P0.05)。結(jié)合實(shí)驗(yàn)研究結(jié)束后的隨訪表明,在中藥外敷聯(lián)合口服夏枯草顆粒治療良性單純性甲狀腺結(jié)節(jié)方面的復(fù)發(fā)率優(yōu)于單純口服夏枯草顆粒。結(jié)論:從初步臨床研究分析,中藥外敷聯(lián)合口服夏枯草顆�？梢愿纳屏夹詥渭冃约谞钕俳Y(jié)節(jié)患者的臨床癥狀、縮小結(jié)節(jié)大小、降低復(fù)發(fā)率,未引起患者的甲狀腺功能及甲狀腺抗體的變化,未見(jiàn)肝腎功能的損害,此方法安全、經(jīng)濟(jì)、有效、可靠,其作用機(jī)制值得進(jìn)一步研究,為廣大患者降低痛苦。
[Abstract]:Objective: to observe the clinical effect of external application of traditional Chinese medicine on benign simple thyroid nodules (liver stagnation, phlegm and blood stasis), and to study the effect of the plaster on benign simple thyroid nodules, as well as the efficacy and safety of the plaster. The contents and data of this study were summarized and analyzed to further standardize the technical operation method of external application of traditional Chinese medicine in order to find an effective, safe, standardized and convenient method for external treatment of this disease. Methods: in this study, 60 patients with benign thyroid nodules (liver depression, phlegm and blood stasis) were randomly divided into two groups. The control group was treated with Prunella vulgaris granules. The clinical efficacy was evaluated after 12 weeks and 12 weeks. The changes of clinical symptoms and signs, as well as the changes of related indexes, including the diameter of the largest thyroid nodule and the thyroid function, were evaluated before and after treatment. Liver and kidney function, blood routine, safety index, TCM symptom score and curative effect score, and record. Control before and after treatment, improvement or no change, the experimental results were statistically analyzed. All the data were analyzed by SPSS 17.0 software. Results: there was no significant difference in sex, age, course of disease and the diameter of the largest nodule of thyroid nodule between the two groups before treatment (P 0.05), which indicated that the data of the two groups were comparable. There are differences in the total effective rate, the curative effect of TCM symptoms, the integral of TCM symptoms, the degree of reduction of thyroid nodules, and so on. Combined with the follow-up after the experimental study, the recurrence rate of traditional Chinese medicine combined with oral Prunella granulosa in the treatment of benign simple thyroid nodules was better than that of oral Prunella granulosa. Conclusion: from the preliminary clinical study, the clinical symptoms of benign simple thyroid nodules can be improved, the size of nodules and the recurrence rate can be reduced by external application of traditional Chinese medicine combined with oral administration of Prunella solani granules. This method is safe, economical, effective and reliable. Its mechanism is worthy of further study and can reduce the pain for the majority of patients.
【學(xué)位授予單位】：黑龍江中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：R259

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