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  本文選題：補腎調(diào)周法 + 高泌乳血癥�。� 參考：《南京中醫(yī)藥大學(xué)》2017年碩士論文

【摘要】：目的:觀察運用補腎調(diào)周法治療高泌乳素血癥(Hyperprolactinemia,HPRL)的臨床療效,探討其作用機理,為診治HPRL提供值得推廣的治療方案和科學(xué)的理論依據(jù)。方法:選取符合納入標準的肝郁腎虛型HPRL患者46例作為研究對象,給予補腎調(diào)周中藥治療3個月。觀察治療前后如月經(jīng)周期延后、月經(jīng)量少、溢乳、乳房脹痛、情緒抑郁或煩躁易怒、經(jīng)行腹痛、脅肋脹滿、腰膝酸軟、咽干口燥、頭暈耳鳴、五心煩熱、夜尿頻多、性欲減弱及舌苔脈象等中醫(yī)癥候的變化,基礎(chǔ)血清性激素(血清泌乳素(PRL)、雌二醇(E2)、睪酮(T)、促黃體生成素(LH)、促卵泡刺激素(FSH))水平的變化以及基礎(chǔ)體溫(BBT)的變化。結(jié)果:①治療效果:治愈5例,占10.87%;顯效11例,占23.91%例;有效25例,占54.35%;無效5例,占10.87%;總有效率89.13%。②治療后中醫(yī)癥候積分較治療前降低,差異具有統(tǒng)計學(xué)意義(P0.01)。其中治療后月經(jīng)周期較治療前顯著規(guī)律(P0.01),月經(jīng)量明顯增多(P0.01),溢乳控制效果顯著(P0.01),乳房脹痛、情緒抑郁或煩躁易怒、五心煩熱、腰膝酸軟、脅肋脹痛、頭暈耳鳴、咽燥口干、舌苔脈象的改善顯著(P0.01),經(jīng)行腹痛、性欲減弱、夜尿頻多明顯改善(0.01P0.05)。③治療后血清PRL低于治療前,具有顯著性差異(P0.01);治療后血清E2高于治療前,具有顯著性差異(P0.01);LH、FSH、T治療前后的變化并無統(tǒng)計學(xué)意義(P0.05)。④治療前后基礎(chǔ)體溫的變化具有顯著性差異(P0.01)。⑤5例治愈患者停藥3月后復(fù)查PRL未見異常升高。⑥治療期間僅4例發(fā)生輕度不良事件,安全性評價高。結(jié)論:補腎調(diào)周法能明顯改善HPRL患者的臨床癥狀,降低PRL,提高E2,改善BBT,復(fù)發(fā)率低,安全性高,具有重要的臨床應(yīng)用價值,值得推廣。
[Abstract]:Objective: to observe the clinical effect of tonifying kidney and regulating week on hyperprolactinemiaHPRL (HyperprolactinemiaHPRL), to explore its mechanism, and to provide a scientific theoretical basis for the treatment of HPRL. Methods: 46 cases of HPRL with liver depression and kidney deficiency were selected as the study object and treated with tonifying kidney and regulating week Chinese medicine for 3 months. Observed before and after treatment, such as delayed menstrual cycle, less menstrual volume, galactorrhea, breast distension, depression or irritability, abdominal pain, full flank, sore waist and knee, dry pharynx, dizziness and tinnitus, five upset heat, frequent urination at night, Changes of sexual desire and tongue coating symptoms, changes of basic serum sex hormones (serum prolactin, estradiol, testosterone, luteinizing hormone, follicle-stimulating hormone FSHO) and basic body temperature (BBT). Results: 5 cases were cured (10.87%), 11 cases were markedly effective (23.91%), 25 cases were effective (54.35%), 5 cases were ineffective (10.87%), and the total effective rate 89.13.2 was lower than that before treatment (P 0.01). The menstrual cycle after treatment was more regular than that before treatment (P0.01A), the menstrual volume increased significantly (P0.01A), and the control effect of galactorrhea was significant (P0.01A), breast distended pain, emotional depression or irritability and irritability, five upset heat, sore waist and knee, flabby rib pain, dizziness tinnitus, dry pharynx and dry mouth, The improvement of pulse appearance of tongue coating was significant (P0.01A), abdominal pain and decreased libido. The frequency of nocturnal urination was significantly improved. The serum PRL after treatment was significantly lower than that before treatment (P 0.01), and the serum E 2 level was higher than that before treatment. There was no significant difference in basic body temperature before and after treatment with P0.01FSHT. There was a significant difference in basal body temperature before and after treatment. 55 cases of cured patients had no abnormal elevation of PRL after 3 months after drug withdrawal. Only 4 cases had mild adverse events. The safety evaluation is high. Conclusion: the method of tonifying the kidney and regulating the week can obviously improve the clinical symptoms, reduce the PRL, increase the E2 and improve the BBT. The recurrence rate is low and the safety is high. It has important clinical application value and is worth popularizing.
【學(xué)位授予單位】：南京中醫(yī)藥大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R271.9

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