本文選題：子宮內(nèi)膜樣腺癌 + 脂聯(lián)素受體�。� 參考：《廣西醫(yī)科大學(xué)》2017年碩士論文

【摘要】：目的:探討脂聯(lián)素受體(AdipoR1、Adipo R2)和胰島素受體底物1(IRS-1)在子宮內(nèi)膜樣腺癌組織中的表達與臨床病理特征的關(guān)系及臨床意義。方法:應(yīng)用免疫組織化學(xué)Max Vision法檢測80例子宮內(nèi)膜腺癌組織、26例不典型增生組織、23例正常子宮內(nèi)膜組織中AdipoR1、Adipo R2和IRS-1的表達情況,并分析AdipoR1、AdipoR2和IRS-1與子宮內(nèi)膜腺癌臨床病理特征的關(guān)系。統(tǒng)計學(xué)上計數(shù)資料采用卡方檢驗或四格表Fisher確切概率法及Spearman等級相關(guān)分析。結(jié)果:AdipoR1在子宮內(nèi)膜腺癌、不典型增生、正常子宮內(nèi)膜組織中均有表達,陽性表達率分別為62.5%、73.1%和91.3%,子宮內(nèi)膜腺癌組陽性率低于正常子宮內(nèi)膜組(P0.05),內(nèi)膜癌組與不典型增生組陽性表達率差異無統(tǒng)計學(xué)意義。Adipo R2在子宮內(nèi)膜腺癌、不典型增生、正常子宮內(nèi)膜組織中陽性表達率分別為67.5%、76.9%和95.7%,子宮內(nèi)膜腺癌組陽性率低于正常子宮內(nèi)膜組(P0.05),內(nèi)膜癌組與不典型增生組陽性表達率差異無統(tǒng)計學(xué)意義。IRS-1在子宮內(nèi)膜腺癌、不典型增生、正常子宮內(nèi)膜組織陽性表達率分別為72.5%、80.7%和69.6%,三組間相互比較差異無統(tǒng)計學(xué)意義。在子宮內(nèi)膜腺癌中,AdipoR1的低表達與FIGO分期、病理分級、肌層浸潤深度、淋巴結(jié)轉(zhuǎn)移、淋巴脈管受累有關(guān)。AdipoR2的低表達與組織分化程度有關(guān),與其他臨床病理特征無明顯相關(guān)性。IRS-1的高表達與FIGO分期、病理分級、淋巴結(jié)轉(zhuǎn)移有關(guān)。相關(guān)性分析顯示,AdipoR1與PR的表達呈正相關(guān);AdipoR1、AdipoR2與P53的表達呈負(fù)相關(guān),而與ER、Ki-67的表達無明顯相關(guān)性。IRS-1與P53、Ki-67的表達呈正相關(guān)。AdipoR1與AdipoR2的表達呈正相關(guān),AdipoR1、AdipoR2與IRS-1的表達呈負(fù)相關(guān)。結(jié)論:AdipoR在正常子宮內(nèi)膜、不典型增生、子宮內(nèi)膜腺癌組織中的表達呈遞減趨勢,IRS-1表達無明顯差異,AdipoR與子宮內(nèi)膜樣腺癌的發(fā)生有關(guān)。AdipoR表達下降、IRS-1表達增高可能與子宮內(nèi)膜腺癌的發(fā)展、浸潤、轉(zhuǎn)移有關(guān),AdipoR起抑制作用,而IRS-1可能起促進作用,其中主要作用可能是通過AdipoR尤其是Adipo R1來實現(xiàn)。檢測AdipoR和IRS-1的表達對預(yù)測腫瘤的生物學(xué)行為具有一定的意義。
[Abstract]:Objective: to investigate the relationship between the expression of adiponectin receptor AdipoR1 (Adipo R2) and insulin receptor substrate 1 (IRS-1) in endometrial adenocarcinoma and its clinical significance. Methods: immunohistochemical Max Vision method was used to detect the expression of AdipoR1 Adipo R2 and IRS-1 in 23 normal endometrial tissues from 26 cases of atypical hyperplasia in 80 cases of endometrial adenocarcinoma. The relationship between AdipoR _ 2 and IRS-1 and clinicopathological features of endometrial adenocarcinoma was analyzed. Statistically counting data were analyzed by chi-square test or Fisher exact probability method and Spearman rank correlation analysis. Results in endometrial adenocarcinoma, atypical hyperplasia and normal endometrial tissues, the expression of 1% AdipoR1 was found in normal endometrium. The positive expression rates were 62.5% and 91.3%, respectively. The positive rate of endometrial adenocarcinoma was lower than that of normal endometrium (P 0.05). There was no significant difference between endometrial carcinoma group and atypical hyperplasia group. Adipo R2 had no significant difference in endometrial adenocarcinoma and atypical hyperplasia. The positive rate of positive expression in normal endometrium was 67.5% and 95.77.The positive rate of endometrial adenocarcinoma was lower than that of normal endometrium (P 0.05). There was no significant difference in positive expression of IRS-1 between endometrial carcinoma group and atypical hyperplasia group. The positive expression rates of atypical hyperplasia and normal endometrium were 72.5% and 69.6% respectively. There was no significant difference among the three groups. The low expression of AdipoR1 in endometrial adenocarcinoma was related to FIGO stage, pathological grade, depth of myometrial invasion, lymph node metastasis and lymphatic vascular involvement. There was no significant correlation with other clinicopathological features. The high expression of IRS-1 was related to FIGO stage, pathological grade and lymph node metastasis. Correlation analysis showed that the expression of AdipoR1 and PR was positively correlated with the expression of AdipoR1AdipoR2 and p53, but not with the expression of ERPKi-67. IRS-1 was positively correlated with the expression of P53 Ki-67. AdipoR1 was positively correlated with the expression of AdipoR2. AdipoR1AdipoR2 was negatively correlated with the expression of IRS-1. ConclusionAdipoR is atypical hyperplasia in normal endometrium. There was no significant difference in the expression of IRS-1 between endometrial adenocarcinoma and endometrial adenocarcinoma. The decrease of IRS-1 expression in endometrial adenocarcinoma may be related to the development, invasion and metastasis of endometrial adenocarcinoma. IRS-1 may play a catalytic role, and the main role may be achieved through AdipoR, especially Adipo R1. Detection of the expression of AdipoR and IRS-1 may be helpful to predict the biological behavior of tumor.
【學(xué)位授予單位】：廣西醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R737.33

【參考文獻】

相關(guān)期刊論文 前10條

1 謝平,劉美蓮,曾衛(wèi)民,黃建軍,陳淑華,盧瑾,徐霞,宋惠萍;雌激素和高胰島素調(diào)節(jié)胰島素受體底物-1,2表達機制研究[J];中國病理生理雜志;2005年01期

2 張峻霄;王建六;趙麗君;劉寧;李小平;孫蓬明;魏麗惠;戴琳;董建強;;胰島素受體α、β及胰島素受體底物-1在子宮內(nèi)膜癌的表達及其臨床意義[J];中國婦產(chǎn)科臨床雜志;2007年05期

3 戴吉茹;王蕊;俞進;劉朝霞;李宏利;;胰島素受體底物-1在子宮內(nèi)膜癌中的表達[J];中國婦幼保健;2009年07期

4 崔曉兵;韓意;李麗;吳立玲;;脂聯(lián)素受體表達調(diào)控的研究進展[J];生理科學(xué)進展;2011年03期

5 張麗志;溫克;劉榮;瞿全新;;脂聯(lián)素對子宮內(nèi)膜癌細(xì)胞增殖凋亡的影響[J];現(xiàn)代婦產(chǎn)科進展;2010年07期

6 王仙玉;郭錦芳;包月芳;;胰島素抵抗與子宮內(nèi)膜癌發(fā)生的關(guān)系研究[J];全科醫(yī)學(xué)臨床與教育;2012年03期

7 Kakali Ghoshal;Maitree Bhattacharyya;;Adiponectin: Probe of the molecular paradigm associating diabetes and obesity[J];World Journal of Diabetes;2015年01期

8 劉子瑜;張潔清;莫哲倫;李力;;胰島素抵抗與子宮內(nèi)膜癌發(fā)生相關(guān)性研究[J];中國實用婦科與產(chǎn)科雜志;2014年09期

9 李翡;鄭偉;李小寧;朱虹麗;;子宮內(nèi)膜增生患者胰島素抵抗指數(shù)和脂聯(lián)素水平的變化與相關(guān)性[J];西部醫(yī)學(xué);2015年12期

10 Arnav Katira;Peng H.Tan;;Evolving role of adiponectin in cancer-controversies and update[J];Cancer Biology & Medicine;2016年01期

，

本文編號：1807797