本文選題：白癜風(fēng) + 毫火針�。� 參考：《廣州中醫(yī)藥大學(xué)》2017年碩士論文

【摘要】：目的:通過數(shù)碼成像結(jié)合Image-Pro-Plus(IPP)圖像處理分析軟件的方法,觀察毫火針聯(lián)合他克莫司軟膏治療白癜風(fēng)的臨床療效。方法:將符合納入標(biāo)準(zhǔn)的45例白瘢風(fēng)患者納入試驗,將其靶皮損按照自身對照的方法分為治療側(cè)、對照側(cè),治療側(cè)予毫火針針刺,每周1次,同時外用0.1%他克莫司軟膏治療,每天2次,對照側(cè)單用0.1%他克莫司軟膏治療。兩組均在治療的第0周、第4周、第8周、第12周對靶皮損進(jìn)行數(shù)碼圖像采集,應(yīng)用IPP圖像處理分析軟件計算皮損面積,從而進(jìn)行相應(yīng)的統(tǒng)計學(xué)處理,同時記錄試驗中的不良反應(yīng)。結(jié)果:納入的45例患者,試驗中3例患者脫落(均為失訪),剩余42例完成規(guī)定療程的治療。觀察皮損共計84塊,治療側(cè)、對照側(cè)各42塊。治療12周后,治療側(cè)總復(fù)色率為39.57%,高于對照側(cè)的10.27%;治療側(cè)總有效率為80.95%,優(yōu)于對照側(cè)的59.52%,治療側(cè)顯效率為30.95%,對照側(cè)則為14.29%,兩組有效率比較P0.05;治療4、8、12周后,兩組有效率對比,4周后治療側(cè)有效率為21.38%,對照側(cè)為9.86%(P0.05);8 周后分別為 46.73%、28.26%(P0.05);12 周后分別為 80.95%、59.52%(P0.05)。治療 4、8、12 周后,治療側(cè)復(fù)色率分別為 9.41%、19.62%、39.52%,對照側(cè)復(fù)色率分別為2.04%、7.87%、10.27%,兩組比較均P0.05。治療12周后,皮損復(fù)色≥75%的皮損數(shù)治療側(cè)為11塊,對照側(cè)為2塊。不同因素下兩組組間靶皮損復(fù)色率比較,顏面部、軀干部兩組比較P0.05,其它因素下治療側(cè)復(fù)色率均氋于對照側(cè)。組內(nèi)不同因素下靶皮損復(fù)色率比較,兩組在年齡的療效差異上P0.05,兩組在病程≤3年與病程3年的復(fù)色率比較P值0.01,在軀干、四肢、手足部的復(fù)色率比較P0.01。兩組在不同部位的復(fù)色率均為手足療效最差,顏面部療效最好,但治療區(qū)療效均氋于對照區(qū)。毫火針針刺治療后均出現(xiàn)紅斑、風(fēng)團(tuán)、刺痛、灼熱感的即刻反應(yīng),單用0.1%他克莫司軟膏治療2例出現(xiàn)瘙癢刺痛,余均未出現(xiàn)不適,試驗過程中未出現(xiàn)感染、疤痕、同形反應(yīng)等嚴(yán)重不良反應(yīng)。結(jié)論:毫火針聯(lián)合0.1%他克莫司軟膏治療穩(wěn)定期非節(jié)段型白癜風(fēng)的療效優(yōu)于單用他克莫司軟膏,且起效時間較短。毫火針聯(lián)合他克莫司軟膏治療白癜風(fēng)安全、有效,且患者依從性好。
[Abstract]:Objective: to observe the clinical effect of Fuhuo acupuncture combined with tacrolimus ointment in the treatment of vitiligo by digital imaging combined with Image-Pro-Plus-IPP image processing and analysis software. Methods: 45 patients with BCG were included in the trial. The target skin lesions were divided into two groups according to the self-control method: the therapeutic side, the control side and the therapeutic side, once a week, and 0.1% tacrolimus ointment was used externally, and the target skin lesion was treated with 0.1% tacrolimus ointment. Two times a day, the control side was treated with 0.1% tacrolimus ointment. In both groups, the target lesions were collected in the 0, 4, 8 and 12 weeks of treatment. The area of the lesions was calculated by using IPP image processing software, and the corresponding statistical processing was carried out. Adverse reactions in the test were also recorded. Results: of the 45 patients involved, 3 patients dropped out (all of them lost the visit, and the remaining 42 patients completed the prescribed course of treatment. A total of 84 lesions were observed, 42 in the therapeutic side and 42 in the control side. After 12 weeks of treatment, the total recovery rate of the treated side was 39.57, which was higher than that of the control side (10.27%), the total effective rate of the therapeutic side was 80.955, which was better than that of the control side (59.52%), the effective rate of the treatment side was 30.95%, the control side was 14.29, the effective rate of the two groups was higher than that of the control side (P0.05), and the total effective rate of the treatment side was 80.12 weeks after treatment, The effective rate of the two groups was 21.38 after 4 weeks, while that of the control group was 9.86 and that of the control group was 46.73and 28.2628 after 8 weeks respectively. After 12 weeks, it was 80.9552 and 59.52 respectively. After 12 weeks of treatment, the color recovery rate of the treated side was 9.41 and 19.62, respectively, and that of the control group was 2.044 and 7.87 respectively, and that of the control group was 10.27. The two groups were all compared with each other (P0.05). After 12 weeks of treatment, the number of lesions 鈮，

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