本文選題：淺表性膀胱腫瘤 + 表柔比星　； 參考：《青海大學(xué)》2017年碩士論文

【摘要】：目的:本研究旨在通過(guò)對(duì)初發(fā)淺表性膀胱腫瘤患者TUR-BT術(shù)后給予表柔比星射頻熱療機(jī)下熱灌注化療與目前常規(guī)應(yīng)用表柔比星灌注化療對(duì)比效果觀察,探索膀胱熱灌注化療對(duì)于降低初發(fā)淺表性膀胱腫瘤術(shù)后復(fù)發(fā)率的效果,借此為初發(fā)淺表性膀胱腫瘤患者術(shù)后提供更多有效的治療選擇。研究方法:方法:收集青海大學(xué)附屬醫(yī)院、山東大學(xué)第二附屬醫(yī)院、萊蕪市人民醫(yī)院泌尿外科2014年2月至2016年1月診斷為初發(fā)淺表性膀胱腫瘤患者共107例,分為試驗(yàn)組和對(duì)照組。其中試驗(yàn)組患者接受常規(guī)TUR-BT,術(shù)后給予表柔比星射頻熱療機(jī)下灌注化療,對(duì)照組患者接受常規(guī)TUR-BT,術(shù)后給予表柔比星灌注化療。利用膀胱鏡及泌尿系彩超觀察兩組患者1年內(nèi)膀胱腫瘤復(fù)發(fā)情況。統(tǒng)計(jì)分析:組間數(shù)據(jù)使用χ2檢驗(yàn)進(jìn)行分析,以P0.05認(rèn)為差別有統(tǒng)計(jì)學(xué)意義。結(jié)果:1、試驗(yàn)組患者共31例,1年內(nèi)復(fù)發(fā)者6例,未復(fù)發(fā)者25例,復(fù)發(fā)率19.35%。2、對(duì)照組患者共76例,1年內(nèi)復(fù)發(fā)者30例,未復(fù)發(fā)者46例,復(fù)發(fā)率39.47%3、兩組數(shù)據(jù)應(yīng)用χ2檢驗(yàn)進(jìn)行分析,χ2=3.992,P=0.046,差異有統(tǒng)計(jì)學(xué)意義。結(jié)論:(1)淺表性膀胱腫瘤經(jīng)尿道膀胱腫瘤電切術(shù)后,規(guī)律給予藥物灌注化療可降低腫瘤復(fù)發(fā)率;(2)淺表性膀胱腫瘤經(jīng)尿道膀胱腫瘤電切術(shù)后,規(guī)律給予表柔比星射頻熱療機(jī)下熱灌注化療與普通灌注化療相比,可有效降低腫瘤復(fù)發(fā)率。
[Abstract]:Objective: to observe the effect of epirubicin radiofrequency hyperthermic perfusion chemotherapy on patients with primary superficial bladder tumor after TUR-BT.To explore the effect of bladder hyperthermic infusion chemotherapy on reducing the recurrence rate of primary superficial bladder neoplasms, so as to provide more effective treatment options for patients with primary superficial bladder neoplasms.Methods: from February 2014 to January 2016, 107 patients with primary superficial bladder tumor were collected from the affiliated Hospital of Qinghai University, the second affiliated Hospital of Shandong University and the Urology Department of Laiwu people's Hospital.They were divided into two groups: experimental group and control group.The patients in the test group received routine TUR-BT, the patients in the control group received routine TUR-BT, and the patients in the control group received epirubicin infusion chemotherapy after operation.Cystoscopy and urography were used to observe the recurrence of bladder tumor in two groups within one year.Statistical analysis: the data between groups were analyzed by 蠂 2 test. The difference was statistically significant (P 0.05).Results in the control group, there were 31 cases, 6 cases recurred within one year, 25 cases did not recur, the recurrence rate was 19.35.2. In the control group, there were 76 cases, 30 cases recurred within one year, and 46 cases did not recur.The recurrence rate was 39.473.The data of the two groups were analyzed by 蠂 2 test. The difference was statistically significant.Conclusion (1) after transurethral resection of superficial bladder neoplasms, regular administration of drug infusion chemotherapy can reduce the recurrence rate of superficial bladder neoplasms after transurethral resection of bladder tumors.Regular administration of epirubicin in radiofrequency hyperthermia machine can effectively reduce the recurrence rate of tumor compared with that of common perfusion chemotherapy.
【學(xué)位授予單位】：青海大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類(lèi)號(hào)】：R737.14

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