本文選題：維吾爾族　切入點(diǎn)：小兒　出處：《新疆醫(yī)科大學(xué)》2017年碩士論文　論文類型：學(xué)位論文

【摘要】：目的:新疆維吾爾族和漢族先天性心臟病小兒體外循環(huán)下凝血功能和肝素耐藥的相關(guān)研究。方法:隨機(jī)選取我院確診為先天性心臟病的維吾爾族、漢族先天性心臟病患兒320例分為維族組和漢族組。于術(shù)前、出室、術(shù)后24h三個時間點(diǎn)分別采血觀察維漢兩組PT、APTT、FIB、TT、PLT的變化,以及手術(shù)時間、體外循環(huán)時間、24小時胸腔引流量、濃縮紅細(xì)胞、血漿用量等方面資料。并根據(jù)PLT計數(shù)和民族將320例患兒分為四組:W1組:維族PLT240×109/L;W2組:維族PLT240×109/L;H1組:漢族PLT240×109/L;H2組:漢族PLT240×109/L。觀察4組術(shù)前PLT計數(shù)對ACT影響以及4組肝素抗凝效果比較。結(jié)果:1兩組患兒不同時間點(diǎn)PT、APTT、FIB、TT、PLT差異均無統(tǒng)計學(xué)意義(P0.05)。術(shù)后24h胸腔引流量,濃縮紅細(xì)胞用量、血漿用量維族組患兒均大于漢族組患兒(P0.05)。2術(shù)前PLT計數(shù)對ACT影響W2與H2相比,差異有統(tǒng)計學(xué)意義(P0.05);W2組肝素耐藥發(fā)生率與H2組相比,差異有統(tǒng)計學(xué)意義(P0.05)維吾爾族患兒肝素相對耐藥的發(fā)生率(12%)明顯高于漢族患兒(5.2%)。結(jié)論:1新疆維吾爾族和漢族先天性心臟病小兒體外循環(huán)下凝血指標(biāo)無差異。維吾爾族小兒術(shù)后24h胸腔引流量,濃縮紅細(xì)胞用量以及血漿用量多于漢族小兒。2術(shù)前PLT計數(shù)大于240×109/L的維族小兒在體外循環(huán)圍手術(shù)期更容易引起ACT縮短,維吾爾族小兒發(fā)生肝素相對耐藥比例高于漢族小兒。
[Abstract]:Objective: to study the relationship between coagulation function and heparin resistance in children with congenital heart disease under cardiopulmonary bypass in Xinjiang Uygur and Han nationality. 320 children with congenital heart disease in Han nationality were divided into Uygur group and Han nationality group. Blood samples were collected before operation, out of the room and 24 hours after operation to observe the changes of PTT APTTT FIBT, operation time, cardiopulmonary bypass (CPB) time and 24 hours thoracic drainage flow in Uygur and Han groups. Concentrated red blood cells, According to PLT count and nationality, 320 children were divided into four groups: Uygur group: PLT240 脳 109% L / L H2 group: Uygur group PLT240 脳 10 9 / L Li H1 group: Han nationality PLT240 脳 10 9 / L Li H 2 group: Han nationality PLT240 脳 10 9 L / L%. The effect of PLT count before operation on ACT and heparin anticoagulation in 4 groups were observed. Results there was no significant difference in PTAPTTT and FIBT between the two groups at different time points (P 0.05). The concentration of red blood cell and the dosage of plasma in Uygur group were higher than those in Han nationality group (P 0.05). The effect of PLT count on ACT in W2 group was significantly higher than that in H2 group. The incidence of heparin resistance in W2 group was significantly higher than that in H2 group. The incidence of heparin relative drug resistance in Uygur children was significantly higher than that in Han children (P 0.05). Conclusion there is no difference in coagulation indexes between Xinjiang Uygur and Han children with congenital heart disease under cardiopulmonary bypass. 24 hours after operation, the thoracic drainage volume in children of er nationality, Uygur children whose PLT count was more than 240 脳 10 9 / L before operation were more likely to shorten ACT during the perioperative period of cardiopulmonary bypass, and the rate of heparin relative resistance in Uygur children was higher than that in Han children.
【學(xué)位授予單位】：新疆醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R726.1

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