本文選題：胃癌　切入點(diǎn)：臨床病理特征　出處：《新疆醫(yī)科大學(xué)》2017年碩士論文　論文類型：學(xué)位論文

【摘要】：目的:探討新疆維吾爾族和漢族胃癌臨床病理特征,并分析EGFR和VEGF在胃癌組織中的表達(dá)及與臨床病理特征的關(guān)系以及二者的相關(guān)性,為疾病的評(píng)估和診治提供幫助。方法:以2011年1月至2015年12月在我院行手術(shù)治療的592例胃癌患者為研究對(duì)象,對(duì)其一般資料及臨床病理等相關(guān)資料進(jìn)行回顧性分析。采用免疫組化SP方法,檢測(cè)其中230例胃癌組織中EGFR和VEGF的表達(dá),并分析其與臨床病理參數(shù)的關(guān)系及二者相關(guān)性。結(jié)果:592例胃癌中,維吾爾族胃癌164例,男女比為3.69:1,漢族428例,男女比為2.92:1,好發(fā)年齡均為51~70歲。維吾爾族胃癌腫瘤部位較漢族相比位置偏上(P0.05)。兩民族胃癌病理組織學(xué)類型均以腺癌居多,進(jìn)展期胃癌大體類型以BorrmannⅡ型為主。維吾爾族早期胃癌6例(3.7%),漢族49例(11.4%),與漢族相比維吾爾族早期胃癌所占比例偏少(P0.05)。維吾爾族胃癌T分期及TNM分期較漢族偏高(P0.05)。EGFR在胃癌組織中的陽性表達(dá)率為23.0%(53/230),VEGF的陽性表達(dá)率18.3%(42/230)。EGFR表達(dá)與淋巴結(jié)轉(zhuǎn)移密切相關(guān)(P0.05),而與腫瘤部位、大小、分化程度、浸潤(rùn)深度、TNM分期及有無癌栓無關(guān)。VEGF與腫瘤分化程度、浸潤(rùn)深度、淋巴結(jié)轉(zhuǎn)移及TMN分期密切相關(guān)(P0.05)。且二者表達(dá)呈相關(guān)性(P0.05)。結(jié)論:維吾爾族和漢族胃癌在臨床病理學(xué)特征上既有相同點(diǎn)也有不同點(diǎn),應(yīng)采取相應(yīng)的診療措施。EGFR和VEGF的表達(dá)在胃癌的發(fā)生、發(fā)展中起重要作用,二者表達(dá)呈相關(guān)性,為胃癌的靶向治療提供依據(jù)。
[Abstract]:Objective: To investigate the Xinjiang Uygur and Han the clinicopathological features of gastric carcinoma, and to analyze the correlation between the expression of EGFR and VEGF in gastric carcinoma and its relationship with clinical pathological features and the two, to provide help for the assessment and diagnosis and treatment of the disease. Methods: from January 2011 to December 2015 in 592 cases of gastric cancer patients in our hospital underwent surgery for research the object, the general data and clinical pathological data were retrospectively analyzed. Using immunohistochemical SP method, the expression of EGFR and VEGF were detected in 230 cases of gastric carcinoma, and analyze its relationship with clinical pathological parameters and the correlation between the two. Results: 592 cases of gastric cancer, 164 cases of gastric cancer in Uygur men and women. Ratio of 3.69:1, 428 cases of Han nationality, male and female ratio of 2.92:1, good hair age 51~70. In gastric tumor site than the Han side compared to the location (P0.05). The two national pathology of gastric cancer histological types were In the most general types of adenocarcinoma, advanced gastric cancer with Borrmann II type. In 6 cases of early gastric cancer (3.7%), 49 cases of Han (11.4%), compared with Han Uygur proportion of early gastric cancer (P0.05). The less the T staging of gastric cancer and TNM staging than the Han high (P0.05) positive expression of.EGFR in gastric cancer tissues was 23% (53/230), the positive expression rate of VEGF was 18.3% (42/230) expression of.EGFR correlated with lymph node metastasis (P0.05), and the tumor size, degree of differentiation, depth of invasion, TNM staging and tumor thrombus.VEGF is not associated with the degree of tumor differentiation, invasion depth, lymph node metastasis and TMN staging are closely related (P0.05). And the two expression correlated (P0.05). Conclusion: the Uygur and Han in gastric cancer clinical and pathological features of both the same, should take corresponding treatment measures of.EGFR and the expression of VEGF in gastric cancer. Birth and development play an important role. The expression of the two is related, which provides a basis for the target treatment of gastric cancer.

【學(xué)位授予單位】：新疆醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：R735.2

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