本文選題：慢性腎功能衰竭　切入點：泄?jié)峁嗄c方　出處：《廣州中醫(yī)藥大學》2017年碩士論文　論文類型：學位論文

【摘要】：目的:通過觀察泄?jié)峁嗄c方治療慢性腎衰(非透析,濕濁瘀阻型)患者的臨床療效,客觀評價其臨床療效和安全性,為臨床決策提供有價值的循證醫(yī)學證據。方法:收集2016.01-2017.01海南省中醫(yī)院腎病科住院診斷為慢性腎衰(非透析,濕濁瘀阻型)的患者,按患者意愿進行分組,根據排除標準,最后納入86例患者,對照組44例,治療組42例。對照組在基礎治療上加尿毒清顆粒沖服,治療組在基礎治療上加用泄?jié)峁嗄c方灌腸。通過觀察兩組患者治療前和治療2周后血肌酐、腎小球濾過率、尿素氮、尿酸及主要臨床癥狀的變化來評估泄?jié)峁嗄c方的療效。結果:治療后治療組患者Scr、BUN、UA水平均較治療前明顯降低,eGFR水平升高,差異均有統(tǒng)計學意義(P01);而對照組患者治療后僅有BUN、UA水平較治療前明顯降低(P0.01)。治療后兩組患者Scr、eGFR 水平相比差異無統(tǒng)計學意義;治療后兩組患者BUN、UA水平比較差異有統(tǒng)計學意義(P0.01、P0.05)。兩組患者治療后乏力、納差、腹脹、水腫癥狀單項評分及總分均較治療前明顯降低(P0.01);而治療后兩組患者這四組癥狀的單項評分及總分組間相比差異無統(tǒng)計學意義(P0.05)。治療后對照組和治療組總體有效率分別為63.6%、85.7%,差異有統(tǒng)計學意義(P05)。本研究中泄?jié)峁嗄c方較為安全,無明顯不良反應;尿毒清顆粒不良反應主要表現(xiàn)為消化道癥狀,占11.4%。結論:泄?jié)峁嗄c方對慢性腎衰患者的血肌酐、尿酸、尿素氮的清除作用較尿毒清顆粒更明顯,治療的總體有效率也優(yōu)于尿毒清顆粒,且無明顯不良反應,是治療慢性腎衰竭患者安全有效的灌腸湯劑。
[Abstract]:Objective: to evaluate the clinical efficacy and safety of Xiezhuo enema prescription in the treatment of chronic renal failure (non-dialysis, dampness and stasis). To provide valuable evidence-based medical evidence for clinical decision-making. Methods: patients with chronic renal failure (non-dialysis, dampness and stasis) were collected from Department of Renal, Hainan traditional Chinese Medicine Hospital from January 2016.01-2017.2017.Methods: patients were divided into groups according to the wishes of the patients and according to the exclusion criteria. Finally, 86 patients were included, 44 in control group and 42 in treatment group. The patients in the treatment group were treated with Xiezhuo enema prescription. The serum creatinine, glomerular filtration rate and urea nitrogen were observed before and after 2 weeks of treatment in the treatment group. The changes of uric acid and main clinical symptoms were used to evaluate the curative effect of Xiezhuoenchang recipe. Results: after treatment, the level of Scr-BUN-UA in the treatment group was significantly lower than that before treatment, and the level of eGFR was increased. The difference was statistically significant (P < 0.01), but the level of Buena in the control group was significantly lower than that before treatment, but there was no significant difference between the two groups in the level of Scrn eGFR after treatment. After treatment, there was a significant difference between the two groups in the level of Buena UA, P0.01and P0.05.After treatment, the patients in the two groups suffered from fatigue, anorexia, abdominal distension, anorexia, abdominal distension, anorexia and abdominal distension. The single score and total score of edema symptoms were significantly lower than those before treatment, but there was no significant difference in the single score and total score of symptoms between the two groups after treatment. The total effective rate of the control group and the treatment group after treatment was higher than that of the control group. The difference was statistically significant (P 05). In this study, Xiezhuo enema was safe, There were no obvious adverse reactions, the adverse reactions of Niaoduqing granules were mainly digestive tract symptoms, accounting for 11.4.Conclusion: the clearance of serum creatinine, uric acid and urea nitrogen in patients with chronic renal failure was more obvious than that in Niaoduqing granules. The overall effective rate of the treatment is also better than that of Niaoduqing granule, and there is no obvious adverse reaction. It is a safe and effective enema decoction for patients with chronic renal failure.
【學位授予單位】：廣州中醫(yī)藥大學
【學位級別】：碩士
【學位授予年份】：2017
【分類號】：R277.5

【參考文獻】

相關期刊論文 前10條

1 王少清;賴瑋婧;匡祀海;肖建平;呂亞萍;毛楠;汪力;;健康體檢人群中慢性腎臟病的流行病學調查[J];保健醫(yī)學研究與實踐;2016年03期

2 王銀浩;;腎功能與血清hs-CRP在糖尿病慢性腎功能不全患者服用尿毒清顆粒前后水平的變化情況分析[J];糖尿病新世界;2016年02期

3 鐘建瑜;梁謀;麥秀軍;林達秋;;健腎消腫飲(益腎宣肺飲)延緩脾腎陽虛型慢性腎衰竭的臨床觀察[J];中國中西醫(yī)結合腎病雜志;2015年09期

4 王永生;劉旭生;;劉旭生教授運用補脾益腎方治療慢性腎衰竭經驗體會[J];中國中西醫(yī)結合腎病雜志;2015年08期

5 陳伯成;;慢性腎臟病的流行病學調查[J];中國衛(wèi)生產業(yè);2015年09期

6 張建東;張曉輝;;左旋卡尼丁聯(lián)合促紅細胞生成素治療腎性貧血的療效觀察[J];中國實用醫(yī)藥;2015年20期

7 梁萌;龔春水;蔡輝;;結腸透析(灌洗結腸療法)的有效性和安全性[J];中國中西醫(yī)結合腎病雜志;2015年03期

8 卿燕;魏平;;尿毒清膠囊對老年慢性腎功能衰竭患者血液流變性及腎功能影響的探討[J];中外醫(yī)療;2014年31期

9 莎仁娜;孫巖;王梅紅;桑曉紅;;1514例成年慢性腎臟病住院患者病因與相關因素分析[J];中國中西醫(yī)結合腎病雜志;2014年09期

10 李娟;;尿毒清顆粒對慢性腎衰竭患者微炎癥狀態(tài)的臨床干預研究[J];泰山醫(yī)學院學報;2014年03期

相關博士學位論文 前1條

1 劉東偉;慢性腎臟病流行病學和危險因素變遷及其系統(tǒng)評價[D];鄭州大學;2015年

相關碩士學位論文 前1條

1 吳禹池;通腑泄?jié)岱ㄖ兴幑嗄c治療慢性腎功能衰竭的臨床觀察研究[D];廣州中醫(yī)藥大學;2011年

，

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