本文選題：帕金森病　切入點：IgG　出處：《新疆醫(yī)科大學》2017年碩士論文　論文類型：學位論文

【摘要】：目的:研究新疆漢族、維吾爾族帕金森病(PD)患者血清中免疫球蛋白(IgG、IgA、IgM)及補體(C3、C4)水平是否具有差異。方法選擇104例原發(fā)性帕金森病患者(PD組),其中漢族64例,維吾爾族40例;選擇135例健康體檢者為對照組,其中漢族84例,維吾爾族51例。采用特種蛋白分析儀檢測血清中免疫球蛋白(IgG、IgA、IgM)及補體(C3、C4)的水平,分析漢族、維吾爾族PD患者的血清免疫球蛋白(IgG、IgA、IgM)、補體水平(C3、C4)是否存在差異及其與PD的關系。結果:PD組IgG值高于對照組(P0.05)。維吾爾族PD組IgA值高于維吾爾族對照組(P0.05)。漢族PD組與漢族對照組IgG、IgA、IgM、C3、C4值差異均無統(tǒng)計學意義(P0.05),漢族PD與維族PD組各指標差異也無統(tǒng)計學意義(P0.05)。將與總體PD相關的五個因素(Ig G、IgA、IgM、C3、C4)進行Logistic回歸分析提示,血清IgG每增加1個單位,PD的發(fā)生風險增加1.675倍(P=0.007,OR=1.675)。進一步將與漢族PD相關的5個因素(IgG、IgA、IgM、C3、C4)進行Logistic回歸分析提示,漢族血清IgG每增加1個單位,漢族PD的發(fā)生風險增加2.096倍(P=0.029,OR=2.096)。但血清Ig G水平與維族PD無關。結論:PD患者IgG值高于正常人;維吾爾族PD患者IgA值高于正常維吾爾族人;漢族組中IgG升高可能增加PD發(fā)病的危險性。
[Abstract]:Objective: to study the difference of serum immunoglobulin (IgG) and complement C _ (3) (C _ (4)) in PD patients of Han nationality and Uygur nationality in Xinjiang. Methods: 104 cases of PD patients with primary Parkinson's disease were selected, including 64 cases of Han nationality and 40 cases of Uygur nationality. 135 healthy persons were selected as control group, including 84 Han nationality and 51 Uygur nationality. Whether there were differences in serum immunoglobulin (IgG) and complement level (C _ 3C _ 4) and their relationship with PD in Uygur patients with PD. Results the IgG value in the group of 10% PD was higher than that in the control group (P 0.05). The value of IgA in the group of Uygur PD was higher than that in the control group (P 0.05), and the value of IgA in the group of PD of Han nationality was higher than that of the control group (P 0.05). There was no significant difference in C _ 3C _ 3 C _ 4 between the two groups, and there was no significant difference in all indexes between PD and Uygur group (P < 0.05). The Logistic regression analysis showed that the five factors related to the total PD were Ig GG IgAU IgMU C _ 3C _ 4, and that there was no significant difference between the two groups (P < 0.05), and there was no significant difference between the two groups (P < 0.05), and there was no significant difference between the two groups (P < 0.05). The risk of serum IgG increased by 1.675 times per unit of PD. The Logistic regression analysis of 5 factors related to PD in Han nationality showed that the serum IgG of Han nationality was increased by 1 unit. The risk of PD in Han nationality was increased by 2.096 times, but the level of serum IgG was not correlated with Uygur PD. Conclusion the IgG value of the patients with PD at 20% is higher than that of the normal people, the IgA value of the patients with PD in Uygur is higher than that of the normal Uygur. Increased IgG may increase the risk of PD in Han nationality.
【學位授予單位】：新疆醫(yī)科大學
【學位級別】：碩士
【學位授予年份】：2017
【分類號】：R742.5

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