發(fā)布時間：2018-01-07 07:20

  本文關(guān)鍵詞：痹寧膠囊對濕熱蘊結(jié)型急性痛風性關(guān)節(jié)炎的臨床療效觀察　出處：《黑龍江中醫(yī)藥大學》2017年碩士論文　論文類型：學位論文

  更多相關(guān)文章： 痹寧膠囊 急性痛風性關(guān)節(jié)炎 濕熱蘊結(jié) 細胞因子

【摘要】：目的:觀察痹寧膠囊治療急性痛風性關(guān)節(jié)炎(濕熱蘊結(jié)型)的有效性以及對IL-1β及IL-18的影響。方法:本研究從黑龍江中醫(yī)藥大學附屬第一醫(yī)院風濕科門診共篩選出符合診斷標準的患者40例,按照隨機原則分為2組,每組20例。其中對照組予秋水仙堿口服;治療組在對照組基礎(chǔ)上予痹寧膠囊口服。兩組在治療過程中均進行基礎(chǔ)治療,療程為10d。10d后觀察兩組患者中醫(yī)證侯總療效和積分、VAS評分、實驗室指標(UA、ESR、CRP)及細胞因子(IL-1β、IL-18)水平的變化。詳細記錄各項指標后進行統(tǒng)計學分析。結(jié)果:1.中醫(yī)證侯總療效:治療組中醫(yī)證侯總有效率為90.0%,對照組中醫(yī)證候總有效率為70.0%,兩組相比差異有統(tǒng)計學意義(P0.05),治療組優(yōu)于對照組。2.中醫(yī)證侯積分:治療組與對照組均可改善患者的中醫(yī)證候積分,兩組對比差異有統(tǒng)計學意義(P0.05),治療組優(yōu)于對照組。3.VAS評分:治療組與對照組均可改善患者的VAS評分,兩組對比差異有統(tǒng)計學意義(P0.05),治療組優(yōu)于對照組。4.相關(guān)實驗室指標:治療組在降低痛風性關(guān)節(jié)炎患者血尿酸、血沉、C-反應蛋白方面均優(yōu)于對照組,差異具有統(tǒng)計學意義(P0.05)。5.細胞因子:治療組在降低痛風性關(guān)節(jié)炎患者IL-1β及IL-18表達方面均優(yōu)于對照組,差異具有統(tǒng)計學意義(P0.05)。結(jié)論:1.痹寧膠囊能夠有效減輕急性痛風性關(guān)節(jié)炎患者(濕熱蘊結(jié)型)的疼痛及相關(guān)臨床癥狀。2.痹寧膠囊能夠降低急性痛風性關(guān)節(jié)炎患者(濕熱蘊結(jié)型)血尿酸水平、血沉水平及C-反應蛋白水平,說明痹寧膠囊可以改善急性痛風性關(guān)節(jié)炎患者實驗室指標。3.痹寧膠囊能夠降低急性痛風性關(guān)節(jié)炎患者(濕熱蘊結(jié)型)血清IL-1β和IL-18的水平,說明痹寧膠囊治療急性痛風性關(guān)節(jié)炎的機制與抑制細胞因子的表達密切相關(guān)。
[Abstract]:Objective: To observe the effect of Bi Ning Capsule in the treatment of acute gouty arthritis (shireyunjiexing) the effectiveness and impact of IL-1 beta and IL-18. Methods: This study from the First Affiliated Hospital of Heilongjiang University Of Chinese Medicine, Department of rheumatism clinic were screened 40 patients met the diagnostic criteria, were randomly divided into 2 groups, 20 cases in each group. The control group was treated with oral colchicine; the treatment group in the control group based on the given Bi capsule. The two groups in the course of treatment was given the basic treatment, treatment for 10d.10d after the two groups were observed in patients with TCM syndrome total curative effect and the integral, VAS score, laboratory indexes (UA, ESR, CRP) and cytokines (IL-1 beta IL-18), changes in the level of statistical analysis. Detailed records of each index. Results: 1. TCM syndrome total curative effect: treatment group TCM syndrome total effective rate was 90%, the control group of TCM syndrome total effective rate was 70%. The difference between the two groups have Statistical significance (P0.05), the control group.2. TCM syndrome score: the treatment group and the treatment group than the control group could improve the TCM syndrome scores, there were statistically significant differences between the two groups (P0.05), the control group is better than the.3.VAS score of treatment group: treatment group and control group all can improve the patient's VAS score, there are statistically significant differences between the two groups (P0.05), the control group of.4. related laboratory index of treatment group than the treatment group in the patients with gouty arthritis reduce blood uric acid, erythrocyte sedimentation rate, C- reactive protein were better than the control group, the difference has statistical significance (P0.05):.5. cytokines in the treatment group decreased IL-1 in patients with gout in beta and IL-18 expression were better than the control group, the difference was statistically significant (P0.05). Conclusion: 1. bining capsule can effectively reduce the patients with acute gouty arthritis (shireyunjiexing) pain and related clinical symptoms of.2. syndrome Ning capsule can reduce the patients with acute gouty arthritis (shireyunjiexing) level of serum uric acid levels, erythrocyte sedimentation rate and C-reactive protein C-, that Bi Ning capsule can improve the acute gout arthritis laboratory indexes in patients with.3. Bi Ning capsule can reduce the patients with acute gouty arthritis (shireyunjiexing) serum IL-1 beta and IL-18 the level of description mechanism of bining capsule in the treatment of acute gouty arthritis is closely related with inhibiting the expression of cytokines.

【學位授予單位】：黑龍江中醫(yī)藥大學
【學位級別】：碩士
【學位授予年份】：2017
【分類號】：R589.7

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