本文關(guān)鍵詞：伴或不伴污染洗滌癥狀強(qiáng)迫障礙患者厭惡的ERP研究　出處：《安徽醫(yī)科大學(xué)》2017年碩士論文　論文類型：學(xué)位論文

  更多相關(guān)文章： 強(qiáng)迫障礙 污染 洗滌 厭惡 事件相關(guān)電位

【摘要】：目的:強(qiáng)迫障礙是一種異質(zhì)性疾病,不同強(qiáng)迫癥狀的發(fā)病機(jī)制?神經(jīng)電生理表現(xiàn)及治療應(yīng)答率均有差異?大量研究表明厭惡在污染/洗滌癥狀強(qiáng)迫障礙的發(fā)生及發(fā)展中占有重要作用。厭惡既可由排泄物?腐爛的食物引起,也可由不道德言行誘發(fā),前者稱為生理厭惡,后者稱為道德厭惡。但厭惡與其他癥狀的強(qiáng)迫障礙之間的關(guān)系研究較少,尚無統(tǒng)一結(jié)論?本研究采用事件相關(guān)電位(event-related potential,ERP)技術(shù)探索伴或不伴污染洗滌癥狀的強(qiáng)迫障礙患者厭惡加工的特點(diǎn),從厭惡角度進(jìn)一步理解強(qiáng)迫障礙的異質(zhì)性?方法:共納入符合《疾病及有關(guān)健康問題的國際分類》(International Statistical Classification of Diseases and Related Health Problems,Tenth Revision,ICD-10)中強(qiáng)迫性障礙診斷標(biāo)準(zhǔn)的門診及住院患者57例。病程中且目前仍伴有污染/洗滌癥狀的強(qiáng)迫障礙患者納入清洗組,病程中且目前無污染/洗滌癥狀的強(qiáng)迫障礙患者納入非清洗組?其中清洗組27人,非清洗組30人?并招募性別?年齡?受教育程度與強(qiáng)迫障礙患者相匹配的健康人作為正常對照組,共50人?所有被試均完成帕多瓦強(qiáng)迫量表?耶魯布朗強(qiáng)迫嚴(yán)重程度量表?漢密頓焦慮量表?漢密頓抑郁量表,在完成詞匯判斷任務(wù)的同時記錄ERP數(shù)據(jù)?結(jié)果:(1)詞匯判斷任務(wù)行為學(xué)結(jié)果:在生理厭惡詞及道德厭惡詞中,非清洗組正確率小于清洗組及正常對照組(均P0.05)?中性詞正確率三組無統(tǒng)計學(xué)差異(P0.05)?清洗組及非清洗組生理厭惡詞?道德厭惡詞反應(yīng)時均長于正常對照組,兩類詞的厭惡程度評級均高于正常對照組(均P0.05),清洗組與非清洗組間無統(tǒng)計學(xué)差異?三組被試中性詞厭惡程度評級無統(tǒng)計學(xué)差異(均P0.05)?(2)ERP數(shù)據(jù)結(jié)果:在P2成分上,生理厭惡詞刺激及道德厭惡詞刺激下,三組誘發(fā)的波幅無統(tǒng)計學(xué)差異?中性詞刺激下,清洗組誘發(fā)的波幅高于正常對照組(均P0.05)?在N2成分上:生理厭惡詞刺激下,清洗組誘發(fā)的波幅高于非清洗組和正常對照組(均P0.05);在道德厭惡詞及中性詞刺激下,清洗組誘發(fā)的波幅均高于非清洗組及正常對照組(均P0.05),非清洗組與正常對照組間無統(tǒng)計學(xué)差異;正常對照組中生理厭惡詞和道德厭惡詞誘發(fā)的N2成分波幅均高于中性詞(均P0.05),清洗組及非清洗組兩組中三類刺激類型誘發(fā)的波幅無統(tǒng)計學(xué)差異(均P0.05)?在LPC成分上:清洗組誘發(fā)的波幅高于非清洗組?不同刺激類型誘發(fā)的波幅中:生理厭惡詞道德厭惡詞中性詞?Pearson相關(guān)分析顯示,污染/洗滌因子分與厭惡詞誘發(fā)的P2成分波幅大小均呈正相關(guān)(均P0.05)?其他強(qiáng)迫癥狀因子分與各腦電成分均無明顯相關(guān)關(guān)系?結(jié)論:伴或不伴污染洗滌/癥狀的強(qiáng)迫障礙患者自我評估中厭惡感均升高;污染/洗滌癥狀患者厭惡加工中污染信念、注意偏向、誘發(fā)情緒強(qiáng)度等過程均有異常,而其他強(qiáng)迫癥狀患者厭惡加工無明顯異常;伴或不伴污染洗滌癥狀的強(qiáng)迫障礙患者之間厭惡加工存在差異,厭惡刺激下腦電活動指標(biāo)可作為潛在的癥狀分型標(biāo)準(zhǔn)之一。本研究從厭惡角度為強(qiáng)迫障礙的異質(zhì)性增加神經(jīng)電生理證據(jù),為強(qiáng)迫障礙個體化治療提供理論依據(jù)?
[Abstract]:Objective: obsessive-compulsive disorder is a heterogeneous disease, the pathogenesis of different obsessive-compulsive symptoms? The electrophysiological features and treatment response rates were different? A large number of studies show that disgust plays an important role in occurrence and development of contamination / washing symptoms of obsessive compulsive disorder. Disgusted either by faeces? Rotten food can also cause. The former is called moral behavior induced by physiological disgust, the latter is called moral disgust. But hate relationship between obsessive compulsive disorder and other symptoms are less, there is no unified conclusion? This study used event-related potential (event-related potential, ERP) in patients with obsessive-compulsive disorder characteristics of disgust processing technology to explore with or without pollution washing symptoms the further understanding of the heterogeneity of obsessive-compulsive disorder from aversion perspective? Methods: International Classification in accordance with < > of diseases and related health problems were included in the International (Statistical Classificati On of Diseases and Related Health Problems, Tenth Revision, ICD-10) strong compulsive disorder diagnostic criteria of outpatient and inpatient patients in 57 cases. In the course of the disease and is still associated with pollution / obsessive-compulsive disorder symptoms in patients with washing cleaning group, and there is no pollution in the course of patients with obsessive-compulsive disorder symptoms in non washing cleaning group? The cleaning group of 27 people, 30 people of non cleaning group and recruited? Sex? Age? Health education in patients with obsessive-compulsive disorder and the degree of matching as a normal control group, a total of 50 people? All the subjects completed Padova YBOCS? Lord Rubrand forced the severity scale? Hamilton Anxiety Scale, Hamilton depression? Scale, record ERP data in the complete lexical decision task at the same time? Results: (1) lexical decision task behavior results in physical disgust words and moral disgust in the word, the correct rate of non cleaning group is less than the normal control group and cleaning Group (P0.05)? Neutral word correct rate of no significant difference between three groups (P0.05) group and non group cleaning cleaning? Physical disgust words? Moral disgust words reaction were longer than the normal control group, the two word aversion ratings were higher than the normal control group (P0.05), no significant difference between the group and non cleaning cleaning group? The three groups of subjects were neutral words. There were no significant differences in rating aversion (P0.05)? (2) results: ERP data on the P2 composition, physical disgust words stimulation and moral disgust words stimulation, no significant differences between the three groups induced by amplitude? Neutral words stimulation, cleaning group induced amplitude higher than the normal control group (P0.05)? N2 component: physical disgust words under the stimulation evoked amplitude is higher than that of group cleaning cleaning group and normal control group (P0.05); in moral disgust words and neutral words under the stimulation of cleaning group induced wave amplitude was higher than that of non cleaning group and normal control group (P 0.05), non cleaning group and the control group had no significant difference; amplitude of N2 component of normal control group in physical disgust words and moral disgust words were higher than that induced by neutral words (P0.05), cleaning group and non cleaning group three kinds of stimulus type induced by two in the group was no significant difference in Statistics (P0.05)? On the LPC composition: cleaning group induced amplitude is higher than that of non cleaning group? Different stimulus types evoked amplitude: physical disgust words moral disgust words neutral words? Pearson correlation analysis showed that the contamination / washing factor scores and disgust words evoked P2 component amplitudes were positively correlated (P0.05) other obsessive-compulsive factors? There was no obvious correlation with the EEG components? Conclusion: with or without pollution washing / patients with obsessive-compulsive disorder symptoms self assessment in disgust were increased; the contamination / pollution washing symptoms in patients with disgust processing in belief, attention bias, emotional Strength of process abnormality, and other compulsive symptoms in patients with no obvious abnormal processing aversion; disgust processing differences between patients with obsessive-compulsive disorder with or without pollution washing symptoms, brain electrical activity under aversive stimuli can be used as indicators of potential symptoms of type standard one. This research increased electrophysiological evidence for the heterogeneity of obsessive-compulsive disorder from the perspective of disgust, obsessive-compulsive disorder for individualized treatment and provide a theoretical basis?

【學(xué)位授予單位】：安徽醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R749.7

【參考文獻(xiàn)】

相關(guān)期刊論文 前6條

1 靳紅;李曉駟;朱春燕;余鳳瓊;董毅;張蕾;謝雯;蔡春嵐;穆菁菁;袁愫;肖季平;;強(qiáng)迫癥道德厭惡感及其與癥狀的關(guān)系[J];中國神經(jīng)精神疾病雜志;2016年03期

2 黃好;羅禹;馮廷勇;李紅;;厭惡加工的神經(jīng)基礎(chǔ)[J];心理科學(xué)進(jìn)展;2010年09期

3 龐礴;朱春燕;汪凱;張蕾;楊平;馬季;;PI-WSUR量表在中國大學(xué)生人群中的修訂[J];中國臨床心理學(xué)雜志;2009年02期

4 張一，孟凡強(qiáng)，崔玉華，，甘向東，郭偉;修改耶魯—布朗強(qiáng)迫量表的臨床信度和效度研究[J];中國心理衛(wèi)生雜志;1996年05期

5 湯毓華;張明園;;漢密頓焦慮量表(HAMA)[J];上海精神醫(yī)學(xué);1984年02期

6 湯毓華;張明園;;漢密頓抑郁量表(HAMD)[J];上海精神醫(yī)學(xué);1984年02期

本文編號：1387474