本文關(guān)鍵詞：柳州市城區(qū)0-6歲兒童脊髓灰質(zhì)炎、麻疹抗體水平及影響因素研究　出處：《廣西醫(yī)科大學(xué)》2017年碩士論文　論文類型：學(xué)位論文

  更多相關(guān)文章： 脊髓灰質(zhì)炎 麻疹 抗體水平 評(píng)價(jià)

【摘要】：研究目的了解柳州市城區(qū)0-6歲健康兒童脊髓灰質(zhì)炎(以下簡(jiǎn)稱脊灰)及麻疹人群抗體水平,探討不同脊灰疫苗免疫程序的免疫效果,初步了解脊灰疫苗的免疫持久性,分析我市脊灰與麻疹抗體陽性的影響因素,評(píng)價(jià)我市免疫規(guī)劃效果,為柳州市免疫規(guī)劃工作提供科學(xué)依據(jù)。研究方法2016年3-7月,選擇柳州市5個(gè)城區(qū)的兒童進(jìn)行人口學(xué)信息及免疫史收集,并采集血樣。采用描述流行病學(xué)方法對(duì)柳州市城區(qū)3727名0-6歲兒童的脊灰抗體及麻疹抗體分布特征進(jìn)行分析。用酶聯(lián)免疫吸附測(cè)定法(Enzyme-linked immunosorbent assay,ELISA)檢測(cè)血樣中的脊髓灰質(zhì)炎病毒IgG抗體和麻疹病毒IgG抗體。采用χ~2檢驗(yàn)、Cochran-Armitage趨勢(shì)性檢驗(yàn)和二分類logistic回歸分析方法比較不同特征兒童脊灰抗體和麻疹抗體水平及影響因素。研究結(jié)果1、脊灰抗體總陽性率為90.4%(3369/3727)。不同性別(χ~2=0.160,P=0.689)、民族(χ~2=3.070,P=0.215)、疫苗種類(χ~2=5.941,P=0.051),兒童脊灰抗體陽性率差異均無統(tǒng)計(jì)學(xué)意義;不同城區(qū)(χ~2=20.879,P0.001)、年齡組(χ~2=9.202,P=0.010)、母親文化程度(χ~2=11.652,P=0.003)、居住屬性(χ~2=21.887,P0.001)、接種劑次(χ~2=10.382,P=0.001),兒童脊灰抗體陽性率差異有統(tǒng)計(jì)學(xué)意義;多因素分析顯示母親文化程度、居住屬性和免后間隔時(shí)間是影響人群抗體陽性的因素;接種3劑次OPV(Z=4.533,P0.001)與接種4劑次IPV(Z=2.537,P=0.006)的兒童脊灰抗體陽性率均隨免疫間隔時(shí)間的增加而下降。2、麻疹抗體總陽性率為99.0%(3691/3727)。不同性別(χ~2=0.045,P=0.832)、民族(χ~2=0.367,P=0.832)、母親文化程度(χ~2=0.281,P=0.869),兒童麻疹抗體陽性率差異均無統(tǒng)計(jì)學(xué)意義;不同城區(qū)(χ~2=12.018,P=0.017)、年齡組(χ~2=16.230,P0.001)、居住屬性(χ~2=8.251,P=0.004)、接種劑次(χ~2=69.610,P0.001),兒童麻疹抗體陽性率差異有統(tǒng)計(jì)學(xué)意義;多因素分析顯示疫苗劑次和免后間隔時(shí)間是影響人群抗體陽性的因素。研究結(jié)論1、柳州市區(qū)0-6歲兒童中脊灰與麻疹抗體陽性率均維持在較高水平,達(dá)到免疫屏障要求,近期發(fā)生此類疫情的可能性較低。2、脊灰疫苗加強(qiáng)免疫及麻疹疫苗復(fù)種是非�？茖W(xué)和必要的。3、柳州市區(qū)免疫規(guī)劃工作整體比較規(guī)范,但應(yīng)加強(qiáng)重點(diǎn)年齡段兒童、流動(dòng)兒童監(jiān)管,加強(qiáng)文化水平較低母親的宣傳工作,并加強(qiáng)對(duì)柳南區(qū)免疫門診的督導(dǎo)和培訓(xùn)工作。
[Abstract]:Objective to investigate the antibody levels of poliomyelitis (polio) and measles in healthy children aged 0-6 years in Liuzhou City, and to explore the immune effect of different immunization procedures of polio vaccine. To understand the immune persistence of poliomyelitis vaccine, to analyze the influencing factors of polio and measles antibody positive in our city, and to evaluate the effect of immunization planning in our city. To provide scientific basis for immunization planning in Liuzhou City. Methods from 2016 to July, 5 urban children in Liuzhou City were selected to collect demographic information and immune history. The distribution characteristics of poliomyelitis antibody and measles antibody in 3727 children aged 0-6 years old in Liuzhou City were analyzed by using the method of descriptive epidemiology. The distribution of polio antibody and measles antibody was determined by enzyme-linked immunosorbent assay (Elisa). Enzyme-linked immunosorbent assay. Elisa was used to detect poliovirus IgG antibody and measles virus IgG antibody in blood samples. Cochran-Armitage trend test and two-classification logistic regression analysis were used to compare the polio antibody and measles antibody levels in children with different characteristics and their influencing factors. The total positive rate of poliomyelitis antibody was 90.4 / 3369 / 37270.There were different sex (蠂 ~ 2 / 0.160) and nationality (蠂 ~ (2 / 2) ~ (3.070)). There was no significant difference in the positive rate of poliomyelitis antibody between children and the type of vaccine (蠂 ~ 2 ~ 2 ~ (5.941) P ~ (0.051)). In different urban areas (蠂 ~ 2 + 2n 20.879) P 0.001, age group (蠂 ~ (2) 9.202), mother's education level (蠂 ~ (2) = 11.652). P0. 003, residential property (蠂 2 + 21. 887%, P 0. 001), inoculum times (蠂 2 + 10. 382% P0. 001). There was significant difference in the positive rate of polio antibody in children. Multivariate analysis showed that the educational level of mother, residence attribute and the interval time after immunity were the factors influencing antibody positive in the population. Three doses of IPV(Z=2.537 were inoculated and 4 doses of IPV(Z=2.537 were inoculated. The positive rate of polio antibody in children with P0. 006) decreased by 2. 2 with the increase of immunization interval. The total positive rate of measles antibody was 99.0 / 3691 / 3727%, with different sex (蠂 ~ (2) 0.045) and nationality (蠂 ~ (2 +) ~ (2) ~ (0.367)). There was no significant difference in the positive rate of measles antibody between children and their mothers (蠂 ~ 2 / 0. 281 ~ 0. 281%, P < 0. 869). Different urban areas (蠂 ~ (2 / 2) ~ (12.018) / P ~ (0.017)), age group (蠂 ~ (2 / 2) ~ (16.230)) P _ (0.001), residence property (蠂 ~ (2) ~ (2)) ~ (8.251). The positive rate of measles antibody in children was significantly higher than that in control group (P < 0.05). Multivariate analysis showed that vaccine dosage and time interval after immunization were the factors influencing antibody positive. Conclusion 1. The positive rates of polio and measles antibodies in children aged 0-6 years in Liuzhou urban area were maintained at a high level. To meet the requirements of the immune barrier, the possibility of such an epidemic in the near future is low, polio vaccine immunization and measles vaccine re-inoculation is very scientific and necessary. 3, Liuzhou city immunization planning work as a whole is more standardized. But we should strengthen the supervision of the key age group, the floating children, strengthen the propaganda work of the mothers with lower education level, and strengthen the supervision and training of the immunization clinic in Liunan district.
【學(xué)位授予單位】：廣西醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：R725.1

【參考文獻(xiàn)】

相關(guān)期刊論文 前10條

1 趙偉棟;頓珠多吉;邊巴倉決;何瑞峰;王德亮;尚殿生;康世軍;;西藏自治區(qū)2014年脊髓灰質(zhì)炎野病毒輸入傳播風(fēng)險(xiǎn)評(píng)估[J];中國疫苗和免疫;2016年06期

2 王素鳳;邱方鵬;;廣西合浦縣6929名健康兒童麻疹、乙腦及脊灰抗體水平監(jiān)測(cè)分析[J];應(yīng)用預(yù)防醫(yī)學(xué);2016年05期

3 倪俐;朱秋艷;張磊;張榕松;丁崢嶸;;2012～2015年云南省紅河州健康人群麻疹抗體水平監(jiān)測(cè)分析[J];中國疫苗和免疫;2016年04期

4 吳昀;冷紅英;陳勇;陳強(qiáng);畢誠;;江蘇省2011-2015年健康兒童脊髓灰質(zhì)炎免疫水平調(diào)查[J];中國病毒病雜志;2016年04期

5 杜云鶴;肖海燕;孟潔;杜松林;;2012年南充市順慶區(qū)1~15歲健康兒童麻疹、脊髓灰質(zhì)炎抗體水平調(diào)查[J];預(yù)防醫(yī)學(xué)情報(bào)雜志;2016年06期

6 王鮮芬;董偉;周紅亮;劉艷;杜小燕;周權(quán);;新疆阿克蘇地區(qū)適齡兒童免疫抗體水平檢測(cè)結(jié)果分析[J];中國衛(wèi)生檢驗(yàn)雜志;2016年11期

7 張榮強(qiáng);李鳳英;;2014年咸陽市0～5歲健康兒童風(fēng)疹等4種傳染病免疫成功率監(jiān)測(cè)評(píng)價(jià)[J];職業(yè)與健康;2016年08期

8 劉心弦;魏忠明;胡海平;胡伯勝;;2013年廣水市健康兒童4種疫苗接種后抗體水平監(jiān)測(cè)結(jié)果分析[J];國際檢驗(yàn)醫(yī)學(xué)雜志;2016年03期

9 董愛虎;李艷;鐘革;劉巍;楊仁聰;杜進(jìn)發(fā);鄧秋云;陳世毅;馬宇燕;甘明;;桂平市1例服苗接觸者VAPP病例流行病學(xué)調(diào)查與處理[J];中國熱帶醫(yī)學(xué);2015年03期

10 樊春祥;張麗芬;宋凱軍;溫寧;蘇琪茹;馬超;郝利新;王華慶;李黎;;中國2014年脊髓灰質(zhì)炎野病毒輸入傳播的風(fēng)險(xiǎn)評(píng)估結(jié)果[J];中國疫苗和免疫;2015年01期

，

本文編號(hào)：1381885