發(fā)布時(shí)間：2018-01-04 23:07

  本文關(guān)鍵詞：類風(fēng)濕關(guān)節(jié)炎發(fā)病與牙周炎的相關(guān)性分析　出處：《新疆醫(yī)科大學(xué)》2017年碩士論文　論文類型：學(xué)位論文

  更多相關(guān)文章： 類風(fēng)濕關(guān)節(jié)炎 牙周炎 抗瓜氨酸化蛋白抗體 牙齦卟啉單胞菌

【摘要】：目的:分析類風(fēng)濕關(guān)節(jié)炎與牙周炎的相關(guān)性,了解影響類風(fēng)濕關(guān)節(jié)炎發(fā)病及疾病活動(dòng)性牙周病學(xué)指標(biāo)。方法:選擇130例初治類風(fēng)濕關(guān)節(jié)炎患者為RA組,50例未患RA的健康體檢者為對(duì)照組,RA組根據(jù)牙周病指數(shù),分為RA1組和RA2組,對(duì)RA組及對(duì)照組進(jìn)行牙周病學(xué)檢查和血清抗牙齦卟啉單胞菌抗體測(cè)定,同時(shí)對(duì)RA組行風(fēng)濕病學(xué)相關(guān)檢查,比較RA組與對(duì)照組間牙周狀況及血清抗牙齦卟啉單胞菌抗體水平的異同,并分析RA患者的風(fēng)濕病學(xué)與牙周病學(xué)檢查指標(biāo)之間的關(guān)系。結(jié)果:(1)一般資料:RA組130人,其中漢族79人,少數(shù)民族51人,年齡46.93±11.99歲。對(duì)照組50人,其中漢族36人,少數(shù)民族14人,年齡41.78±12.61歲。(2)RA組抗P.g抗體水平為40.39±55.58pg/ml;對(duì)照組抗P.g抗體水平為51.31±28.89pg/ml(t=-1.321,P=0.188)。(3)RA組中漢族與少數(shù)民族間抗P.g抗體水平差別無(wú)統(tǒng)計(jì)學(xué)意義(Z=-0.081,P=0.935)。對(duì)照組中漢族與少數(shù)民族間抗P.g抗體水平差別無(wú)統(tǒng)計(jì)學(xué)意義(Z=-0.720,P=0.472)。(4)經(jīng)Pearson相關(guān)性分析,RA組血清抗P.g抗體水平與RF、抗AKA抗體、抗CCP抗體、ESR-DAS28評(píng)分及CRP-DAS28評(píng)分之間的相關(guān)性均無(wú)統(tǒng)計(jì)學(xué)意義。(5)RA組與對(duì)照組的牙周炎檢出率的差別有統(tǒng)計(jì)學(xué)意義(X2=8.412,P=0.004),且易患中、重度牙周炎。(6)PDI和RA的標(biāo)記性抗體抗CCP抗體呈顯著正相關(guān)(r=0.398,P=0.044),但與RF、抗AKA抗體及DAS28之間均無(wú)顯著相關(guān)。結(jié)論:RA患者的牙周炎檢出率高于正常人群,且更易患中、重度牙周炎。牙周病指數(shù)和RA的標(biāo)記性抗體抗CCP抗體呈顯著正相關(guān),但與RF、抗AKA抗體及DAS28之間均無(wú)顯著相關(guān)。血清抗P.g抗體水平在RA患者和正常人群中無(wú)顯著差異。血清抗P.g抗體和RA的診斷性指標(biāo)(RF、抗AKA抗體及抗CCP抗體)及活動(dòng)性指標(biāo)(ESR-DAS28及CRP-DAS28)之間均無(wú)顯著相關(guān)。
[Abstract]:Objective: to analyze the correlation between rheumatoid arthritis (RA) and periodontitis and to understand the indexes of rheumatoid arthritis (RA) and active periodontal disease. Methods: 130 patients with primary rheumatoid arthritis (RA) were selected as RA group. 50 healthy persons without RA were divided into RA1 group and RA2 group according to periodontal disease index. Periodontal diseases and serum antibodies against Porphyromonas gingivalis were detected in RA group and control group, and rheumatological examination was performed in RA group. To compare the periodontal status and serum antibody level of porphyromonas gingivalis between RA group and control group. The relationship between rheumatology and periodontal examination in RA patients was analyzed. The age was 46.93 鹵11.99 years old. The control group consisted of 50 persons, including 36 Han nationality and 14 minority nationalities. The anti-P.g antibody level was 40.39 鹵55.58 PG / ml in RA group aged 41.78 鹵12.61 years. The level of anti-P.g antibody in the control group was 51.31 鹵28.89pg / ml ~ (-1) -1.321. There was no significant difference in the level of anti-P.g antibody between Han nationality and minority nationality in group A (P < 0. 188, P < 0. 88, P < 0. 081, P < 0. 081). There was no significant difference in the level of anti-P.g antibody between Han and ethnic minorities in the control group. By Pearson correlation analysis, the serum levels of anti-P.g antibody, anti-RFR, anti-#en1# antibody and anti-#en2# antibody in RA group were analyzed. There was no significant correlation between ESR-DAS28 score and CRP-DAS28 score. There was significant difference in the detection rate of periodontitis between RA group and control group (P < 0.05). X2 + 8.412. There was a significant positive correlation between anti CCP antibody of severe periodontitis and RA, but it was associated with RF. There was no significant correlation between anti AKA antibody and DAS28. Conclusion the positive rate of periodontitis in patients with 0: RA is higher than that in normal subjects, and it is more susceptible to infection. In severe periodontitis, periodontal disease index was positively correlated with anti CCP antibody of RA, but it was associated with RF. There was no significant correlation between anti AKA antibody and DAS28. There was no significant difference in serum anti P g antibody level between RA patients and normal subjects. There was no significant correlation between anti AKA antibody and anti CCP antibody and the activity index of ESR-DAS28 and CRP-DAS28.
【學(xué)位授予單位】：新疆醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：R593.22;R781.42

【參考文獻(xiàn)】

相關(guān)期刊論文 前5條

1 劉曉飛;王志中;王勇;李景怡;張娟;曾本華;萬(wàn)萍;吳力克;魏泓;方勇飛;;早期類風(fēng)濕關(guān)節(jié)炎患者腸道微生物群落的分析[J];第三軍醫(yī)大學(xué)學(xué)報(bào);2012年23期

2 許福亮;張霞;王云海;;抗環(huán)瓜氨酸肽抗體、葡萄糖6-磷酸異構(gòu)酶及類風(fēng)濕因子的檢測(cè)及對(duì)類風(fēng)濕關(guān)節(jié)炎的診斷價(jià)值[J];免疫學(xué)雜志;2012年08期

3 張媛媛;;精氨酸脫亞胺酶的研究進(jìn)展[J];中國(guó)釀造;2012年06期

4 陳華;姚志建;唐福林;;Sa抗原相關(guān)蛋白質(zhì)的研究[J];中華醫(yī)學(xué)雜志;2006年27期

5 張岱尊;鐘德鈺;鄧婧;王吉波;;牙周炎與類風(fēng)濕關(guān)節(jié)炎的相關(guān)性研究[J];華西口腔醫(yī)學(xué)雜志;2005年06期

，

本文編號(hào)：1380483