本文選題：偏振 + GLP��； 參考：《清華大學》2016年博士論文

【摘要】：偏振光能夠探測生物組織的微觀結(jié)構(gòu)信息,而作為一種非標記、無損傷的檢測技術(shù),偏振成像技術(shù)已經(jīng)在生物醫(yī)學尤其是腫瘤癌癥檢測領域顯示出潛在的應用前景。偏振方法的基礎是偏振測量,快速穩(wěn)定的偏振測量系統(tǒng)對偏振調(diào)制器件提出了較高的要求;同時,由于偏振測量具有復雜的誤差源及誤差傳遞性質(zhì),偏振測量系統(tǒng)必須經(jīng)過合理的設計才能獲得精確的測量結(jié)果。本論文對偏振測量系統(tǒng)的設計方法進行了系統(tǒng)的研究,提出了新型偏振調(diào)制器件和方法,并將偏振設計理論與偏振調(diào)制技術(shù)相結(jié)合進行了生物體系中偏振測量系統(tǒng)的設計。本論文以誤差傳遞為線索,在降噪-優(yōu)化-校準三個方面系統(tǒng)地研究了偏振測量系統(tǒng)的設計方法。本論文研究了全面評估偏振測量系統(tǒng)的方法,兼容現(xiàn)有優(yōu)化指標;研究了檢偏通道數(shù)目對優(yōu)化的影響;歸納了偏振元件誤差的校準方法,提出了非偏振元件偏振殘差的校準方法,并在生物測量系統(tǒng)中對其進行了驗證;提出了光束漂移的校準技巧及相應的60次穆勒矩陣測量方案;提出了最佳校準偏振態(tài)的選取方法。此外,由于待測體系通常具有特定的偏振特征,而且不同的偏振調(diào)制元件具有不同的精度,為了充分利用這兩個特點,論文提出了分步式優(yōu)化和分步式校準的思想。本論文提出了一種新型偏振調(diào)制器件和方法,發(fā)明了基于自聚焦透鏡(GRIN lens)的GLP(GRIN lens polarimeter)偏振測量系統(tǒng)。GRIN lens不僅是波前調(diào)制器件,還是偏振調(diào)制器件。GLP偏振測量系統(tǒng)不僅能夠?qū)崿F(xiàn)單幀同時性偏振態(tài)測量,而且能夠遍歷所有可能的偏振調(diào)制方式,這意味著它不僅包含現(xiàn)有的各種偏振調(diào)制方式,還能開發(fā)出全新的偏振調(diào)制方式。本論文將偏振設計理論與偏振調(diào)制技術(shù)相結(jié)合,設計了生物體系中的新型偏振顯微系統(tǒng)�；诜纸蛊矫嫫裣鄼C的偏振顯微系統(tǒng)既具備最佳的穆勒矩陣測量能力,又具備同時性斯托克斯向量成像能力。通過臨床生物組織病理切片的偏振成像研究,驗證了使用偏振顯微系統(tǒng)進行快速癌癥切片診斷的潛力。同時,本論文總結(jié)了將偏振測量方法應用于生物診斷的步驟:從局部偏振指標測量到全穆勒矩陣測量,再到有針對性的局部偏振指標測量。穆勒矩陣測量能夠反映組織全部的偏振光學信息,而局部偏振指標測量往往更加快速和準確。
[Abstract]:Polarized light can detect the microstructure information of biological tissue. As a non-marker and non-injury-free detection technology, polarization imaging technology has shown a potential application in biomedicine, especially in the field of cancer detection.The polarization measurement method is based on polarization measurement, and the fast and stable polarization measurement system has put forward higher requirements for polarization modulation devices, at the same time, the polarization measurement has complex error sources and error transfer properties.Polarization measurement system must be properly designed to obtain accurate measurement results.In this paper, the design method of polarization measurement system is systematically studied, and a new polarization modulation device and method is proposed. The polarization measurement system in biological system is designed by combining polarization design theory with polarization modulation technology.Based on error transfer, the design method of polarization measurement system is studied systematically in three aspects: noise reduction, optimization and calibration.In this paper, the methods of comprehensive evaluation of polarization measurement system are studied, which are compatible with the existing optimization indexes; the influence of the number of polarization channels on the optimization is studied; and the calibration method of polarization component error is summarized.The calibration method of polarization residuals of non-polarization components is proposed and verified in the biometric system, and the calibration technique of beam drift and the corresponding 60 order Muller matrix measurement scheme are presented.A method for selecting the best calibrated polarization state is proposed.In addition, because the system under test usually has specific polarization characteristics and different polarization modulators have different precision, in order to make full use of these two characteristics, the idea of stepwise optimization and stepwise calibration is proposed in this paper.In this paper, a novel polarization modulation device and method is proposed. The polarization measurement system of GLP(GRIN lens polarimeter.GRIN lens is not only a wavefront modulation device based on self-focusing lens GRINLens.Or the polarization modulation device. GLP polarization measurement system can not only realize single frame simultaneous polarization state measurement, but also can traverse all possible polarization modulation modes, which means that it not only includes all kinds of polarization modulation methods,New polarization modulation can also be developed.In this paper, the polarization design theory and polarization modulation technology are combined to design a new polarization microscope system in biological system.The polarization microscopy system based on the focal plane polarization camera has both the optimal Muller matrix measurement capability and the simultaneous Stokes vector imaging capability.The potential of rapid diagnosis of cancer sections using polarization microscopy was verified by the study of polarization imaging of clinical pathological sections of biological tissues.At the same time, this paper summarizes the steps of applying polarization measurement to biological diagnosis: from local polarization index measurement to full Muller matrix measurement, and then to targeted local polarization index measurement.Muller matrix measurement can reflect all the polarized light information of tissue, and the measurement of local polarization index is more rapid and accurate.
【學位授予單位】：清華大學
【學位級別】：博士
【學位授予年份】：2016
【分類號】：O436.3
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本文編號：1766953