本文關(guān)鍵詞：反滲透集成真空膜蒸餾濃縮中藥水提液的膜傳質(zhì)過程研究　出處：《南京中醫(yī)藥大學(xué)》2017年碩士論文　論文類型：學(xué)位論文

  更多相關(guān)文章： 中藥水提液 反滲透 真空膜蒸餾 閾值通量 膜集成

【摘要】：反滲透(RO)技術(shù)近年來已逐漸用于中藥領(lǐng)域,其操作溫度較低,能充分保護熱敏性有效成分不受破壞,但濃縮倍數(shù)較小。真空膜蒸餾(VMD)技術(shù)具有操作簡便、有效成分損失小、高濃縮比等優(yōu)點,可有效彌補傳統(tǒng)濃縮方法的不足,但與工業(yè)應(yīng)用要求距離尚遠。除了膜污染這一共性問題外,各種膜濃縮過程因其技術(shù)原理而造成的缺陷,也影響到它們優(yōu)勢的發(fā)揮。因此本論文將RO-VMD集成技術(shù)用于中藥水提液的濃縮,研究其過程中流變學(xué)參數(shù)與膜動力參數(shù)的相關(guān)性,并且針對VMD過程的閡值通量、RO過程的臨界滲透壓來優(yōu)化膜工藝,以不同藥用部位的中藥水提液主要實驗體系,進行了 RO-VMD集成切換"臨界點"研究,并對RO-VMD集成過程進行評價;優(yōu)化RO與VMD的耦合過程,對中藥提取液的有效濃縮實現(xiàn)過程控制具有現(xiàn)實意義。本論文主要研究內(nèi)容與結(jié)果如下:1以蒲公英、槐米等4種中藥水提液為研究體系,進行RO-VMD集成初步研究,藥液在進入反滲透系統(tǒng)(0.45 MPa,30℃)200 min后,大多數(shù)藥液滲透壓都已超過外加壓力,即反滲透過程驅(qū)動壓力已降為0MPa,膜過程應(yīng)當難以繼續(xù),否則會對膜組件有較大傷害。當藥液滲透壓出現(xiàn)平衡值時,膜過程驅(qū)動壓力也剛好為0MPa,是所要尋找的最佳平衡點,因此對膜蒸餾、反滲透過程需要進一步的探討適宜的濃縮工藝參數(shù)。2以萊菔子水提液為研究對象,以壓力遞增實驗確定了VMD過程中的閾值通量以及極限通量,分析了不同條件下的通量衰減、阻力、TPC值以及膜表面的SEM圖,當在極限通量下時,運行180min后膜通量降低了 15.4%,而在閾值通量下,膜通量只降低了 1.63%,且10min內(nèi)通量幾乎穩(wěn)定,表明可逆污染層形成非常迅速,且極限通量下的膜阻力是閾值通量的2.5倍,增加能耗。因此,在閾值通量下運行可避免嚴重的通量衰減,也比較節(jié)能,且更適合于長時間運行,實現(xiàn)在某操作條件下,可逆污染可能無法避免的情況下達到不可逆污染的最小化,證明了閾值通量對更好地設(shè)計膜過程,延長膜壽命有重要的作用。3選擇不同藥用部位的其他6種中藥水提液,研究真空膜蒸餾過程中的閾值通量,分析藥液的物理化學(xué)性質(zhì)與閾值線(K值)以及閾值點(真空度、閾值通量)之間的相關(guān)性。隨著濃度增大,閾值點會前移,由于不可逆污染的提前發(fā)生。通過Pearson相關(guān)系數(shù)和聚類分析結(jié)果可知,藥液的密度、黏度和粒徑分布對閡值線以及閾值點的影響較大,其中,密度正相關(guān),黏度和粒徑負相關(guān)。4綜合分析RO-VMD集成過程對于中藥水提液濃縮的適應(yīng)性,以及不同中藥水提液過膜前后理化性質(zhì)的變化。由測定結(jié)果可知,濃縮前后理化參數(shù)均發(fā)生變化,pH值變化幅度較小,而電導(dǎo)率、濁度、粘度、固含物含量均大幅度增加,與濃縮過程中藥液的濃度增大存在密切關(guān)系。膜集成過程對各藥液指標性成分的截留率均在93%以上,且通過中藥水提液濃縮前后的液相特征圖譜分析,各中藥的濃縮液與原液的相似度均大于0.93,說明RO-VMD集成濃縮過程對藥液總體性質(zhì)影響不大,可以很好地維持藥液體系可能的藥效成分組的完整性。綜上,本論文從實際應(yīng)用問題出發(fā),在研究VMD過程中引入閾值通量的概念,為探索合適的膜工藝過程設(shè)計提供基礎(chǔ)研究數(shù)據(jù),以減少膜污染并提高膜分離濃縮效率。將反滲透以及膜蒸餾技術(shù)進行集成以探索其對于中藥水提液濃縮的適應(yīng)性,具有原創(chuàng)性。
[Abstract]:Reverse osmosis (RO) technology in recent years has been gradually used in the field of traditional Chinese medicine, its operating temperature is low, can fully protect the labile compounds from destruction, but the concentration is small. The vacuum membrane distillation (VMD) technology has the advantages of simple operation, small loss of effective components, high concentration ratio and other advantages, can effectively make up for the shortcomings of traditional concentration method but, with the requirements of industrial application range is still far away. In addition to the common problem of membrane fouling, membrane defect concentration process because of its technical principle and cause, also affect their advantages. So this paper will integrate RO-VMD technology for water extract concentration, correlation between the parameters and dynamic rheological parameters of membrane the learning process, and the value for the VMD flux process threshold, to optimize the membrane process pressure critical infiltration RO process, the water extracts of different parts of the main experimental system, the RO-VMD integrated switch" The critical point of research, and to evaluate the RO-VMD integration process; coupling process optimization of RO and VMD, the effective concentration extraction process has practical significance. The main contents and results are as follows: 1 to 4 kinds of dandelion, Flos Sophorae herb extracts as the research system, RO-VMD preliminary study integrated liquid in the reverse osmosis system (0.45 MPa, 30 C) after 200 min, most liquid osmotic pressure applied pressure has exceeded, namely reverse osmosis process driven pressure has been reduced to 0MPa, membrane processes should be difficult to continue, otherwise there will be greater damage to the membrane. When the liquid osmotic pressure balance value. Just as the pressure driven membrane process 0MPa, is to find the best balance point, so the membrane distillation, reverse osmosis process need to concentrate process parameters of.2 suitable to Raphani extract as the research object in order to further increase the pressure. In the process of the experiment to determine the VMD threshold limit flux and flux analysis under different conditions of flux decay resistance, TPC value and SEM diagram of the membrane surface, when the flux in the limit when running the 180min membrane flux decreased by 15.4%, while in the threshold flux, the flux only decreased by 1.63%, and 10min flux is almost stable, show that the reversible fouling layer formed very rapidly, and the limit flux of membrane resistance is 2.5 times the threshold flux increases energy consumption. Therefore, to avoid severe flux decline runs in the threshold flux, but also more energy, and more suitable for long time operation, to achieve in a certain operating conditions reversible pollution may not be able to avoid the case to minimize irreversible pollution, proved that the threshold flux on the better design of membrane process, prolong the service life of the membrane has an important role for.3 in different medicinal parts of other 6 kinds of Chinese medicinal herbs extract, research The threshold flux of vacuum membrane distillation process, analysis of physical and chemical properties of the liquid and the threshold line (K) and threshold (vacuum, threshold flux) correlation. With the increase of the concentration, the threshold point will move forward because of the irreversible pollution occur in advance. Through the Pearson correlation coefficient and cluster analysis results, liquid the density, viscosity and particle size distribution of threshold value and threshold point line effect is large, the density of positive correlation, negative correlation between.4 viscosity and particle size analysis of RO-VMD integrated process for water extract concentrated adaptability to changes before and after the water extract of Chinese herbs and different membrane physicochemical properties by the determination. Results showed that the concentration before and after the physicochemical parameters are changed, the pH value changed little, while the electrical conductivity, turbidity, viscosity, solid content were greatly increased, high concentration has a close relationship with the Chinese medicine liquid concentration process of membrane set increased. A rate of more than 93% of the retention index of component liquid, and the water extract concentrated liquid phase fingerprint analysis and similarity, concentrated liquid and liquid the medicine was greater than 0.93, indicating that RO-VMD integrated concentration process has little effect on the overall properties of the liquid, can well maintain the integrity of the liquid the system may pharmaceutical components group. In conclusion, this thesis is from the practical problems, introduce the concept of threshold flux in VMD process, provide basic data for the exploration of film process design appropriate, to reduce membrane fouling and improve membrane separation efficiency. The concentration of reverse osmosis and membrane distillation technology integrated with to explore the originality for water extract concentrated adaptability.

【學(xué)位授予單位】：南京中醫(yī)藥大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：TQ461;TQ028.8

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