【摘要】：目的:明確凝膠模板工藝過(guò)程中微粒粒徑大小和不同溶劑體系對(duì)甘草次酸微粒性質(zhì)的影響。方法:采用新型凝膠模板法,分別利用不同孔徑模板和不同溶劑體系制備甘草次酸-PLGA微粒,掃描電鏡觀察其表面形態(tài),測(cè)定載藥量及包封率,比較體外釋藥特征。結(jié)果:所得微粒呈微小圓柱體,粒徑均一、形態(tài)可控,載藥量較高,改變粒徑大小和溶劑體系可調(diào)節(jié)微粒體外釋放度。結(jié)論:凝膠模板法微粒制備技術(shù)可精確控制微粒粒徑和形態(tài),適用溶劑廣泛,有利于緩釋微粒給藥系統(tǒng)的釋藥調(diào)節(jié)。
[Abstract]:Aim: to investigate the effect of particle size and solvent system on the properties of glycyrrhetinic acid particles in gel template process. Methods: a new gel template method was used to prepare glycyrrhetinic acid-PLGA particles using different pore size templates and different solvent systems respectively. The surface morphology of glycyrrhetinic acid (PLGA) particles were observed by scanning electron microscope (SEM). The drug loading and encapsulation efficiency were measured and the drug release characteristics in vitro were compared. Results: the particle size was uniform, the morphology was controlled, the drug loading was high, and the external release of microsomes could be adjusted by changing the particle size and solvent system. Conclusion: the gel template method can accurately control the particle size and morphology, is suitable for a wide range of solvents, and is beneficial to the drug release regulation of the drug delivery system.
【作者單位】： 寧夏醫(yī)科大學(xué)藥學(xué)院;青海民族大學(xué)藥學(xué)院;回醫(yī)藥現(xiàn)代化省部共建教育部重點(diǎn)實(shí)驗(yàn)室;寧夏回藥現(xiàn)代化工程技術(shù)研究中心;
【基金】：國(guó)家自然科學(xué)基金(81360644) 寧夏回族自治區(qū)科技支撐國(guó)際合作項(xiàng)目(寧科計(jì)字[2013]21號(hào))
【分類(lèi)號(hào)】：R943

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