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  本文選題：乙醇　切入點：代謝動力學　出處：《四川大學》2005年碩士論文　論文類型：學位論文

【摘要】：乙醇(alcohol)俗稱酒精,是酒精飲料的主要成分,是世界范圍內被普遍濫用的一種物質。過量飲酒對中樞神經(jīng)系統(tǒng)、心腦血管、消化系統(tǒng)、周圍神經(jīng)末梢都有損傷,可導致精神障礙、心衰、中毒性腦病、肝病(包括乙醇肝、脂肪肝、肝硬化)及多發(fā)性神經(jīng)炎等。過量飲酒也可能會引起行為異常,導致意外甚至犯罪,比如車禍、吸入嘔吐物窒息而死、酒后肇事等。 很多情況下都需對血液中乙醇濃度(blood alcohol concentration, BAC)進行檢測,并以BAC檢測結果作為正確處理與乙醇有關的事(案)件的主要依據(jù)。飲酒后BAC與乙醇代謝動力學密切相關,以往有學者試圖揭示出普遍適用的乙醇代謝動力學規(guī)律,并由此來推測飲酒個體某一時刻的BAC,或根據(jù)BAC推測實際飲酒量。但實際上乙醇代謝動力學受飲酒方式、飲酒的種類、飲酒時所吃的食物種類以及肝酶活性等多種因素的影響。此類問題受到眾多學者的關注,而有關這方面的研究又少見報道。本研究希望通過實驗建立一個可適應多種情況下的檢測乙醇的方法,并運用所建立的方法檢測志愿者在不同研究條件下飲酒后不同時刻的BAC,由此研究酒的種類、飲酒時間及不同飲酒個體對乙醇代謝動力學的影響,為進一步揭示乙醇代謝動力學規(guī)律提供基礎研究資料。 在檢測BAC的實際工作中,會遇到各種各樣的檢材,檢材中除含有我們感興趣的目標化合物乙醇而外,可能同時還包含其他一些物質,如乙醛、
[Abstract]:Alcohol alcohol) commonly known as alcohol, is the main component of alcoholic beverages and is a substance commonly abused worldwide. Excessive drinking has damage to the central nervous system, cardiovascular and cerebrovascular systems, the digestive system, and the peripheral nerve endings, which can lead to mental disorders. Heart failure, toxic encephalopathy, liver disease (including ethanol liver, fatty liver, liver cirrhosis) and polyneuritis. Excessive drinking can also lead to behavioral abnormalities, accidents and even crimes, such as car accidents, suffocation of vomit, and death. A drunken accident, etc. In many cases, the concentration of ethanol in blood alcohol concentration (BACC) should be measured, and the results of BAC are used as the main basis for correct handling of ethanol-related matters. After drinking, BAC is closely related to the kinetics of ethanol metabolism. In the past, some scholars tried to reveal the universally applicable kinetic law of alcohol metabolism, and then speculated on the individual's drinking amount at a certain time, or according to BAC, but in fact, the alcohol metabolism kinetics was influenced by the drinking mode and the type of alcohol consumption. The variety of food consumed and the activity of liver enzymes have been affected by many factors, such as the type of food consumed, and the activity of liver enzymes, which have attracted the attention of many scholars. This study hopes to establish an experimental method for the detection of ethanol in a variety of situations. The BACs of volunteers at different time after drinking under different research conditions were detected by using the established method. The effects of alcohol types, drinking time and individual alcohol consumption on the kinetics of ethanol metabolism were studied. In order to further reveal the kinetics of ethanol metabolism to provide basic research data. In the actual work of detecting BAC, there will be a variety of samples, which may also contain some other substances, such as acetaldehyde, in addition to ethanol, which is the target compound of interest to us.
【學位授予單位】：四川大學
【學位級別】：碩士
【學位授予年份】：2005
【分類號】：D919

【引證文獻】

相關碩士學位論文 前1條

1 陳國強;汽車駕駛員血液酒精含量的近紅外光譜法無損檢測[D];山東大學;2012年

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本文編號：1579991