小干擾RNA（siRNA）主要參與RNA干擾,通過靶向HBV轉(zhuǎn)錄的mRNA并對其進(jìn)行降解來阻止基因翻譯。通過對siRNA進(jìn)行化學(xué)修飾、結(jié)合使用和改進(jìn)其傳遞體系,可增強(qiáng)siRNA的靶向性和穩(wěn)定性。JNJ-3989（ARO-HBV）、ARB-1740作為耐受性良好、明顯降低HBsAg水平的siRNA藥物已進(jìn)入臨床研究�，F(xiàn)主要闡述siRNA抑制HBsAg表達(dá)的機(jī)制、siRNA靶向性和穩(wěn)定性的提高以及相關(guān)的臨床前和臨床研究。 

【文章來源】：中華肝臟病雜志. 2020,28(02)

【文章頁數(shù)】： 頁

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