理解胚胎肢體發(fā)育有助于更加全面地了解肢體的發(fā)生和分化,同時(shí)對(duì)于相關(guān)基因療法和肢體再生具有臨床指導(dǎo)意義。本文綜述了頂端外胚層嵴（AER）參與胚胎肢體發(fā)育調(diào)控的研究進(jìn)展及機(jī)理,重點(diǎn)總結(jié)了AER對(duì)肢體發(fā)育三個(gè)軸向的立體調(diào)控,包括基因表達(dá)調(diào)控、信號(hào)通路及相關(guān)調(diào)控中心,并進(jìn)一步討論了各信號(hào)中心之間的交互作用及現(xiàn)有研究待解決問(wèn)題,從而加深對(duì)肢體發(fā)育異常、肢端異常等疾病的理解。 

【文章來(lái)源】：Journal of Zhejiang University-Science B（Biomedicine & Biotechnology）. 2020,21(10)SCICSCD

【文章頁(yè)數(shù)】：10 頁(yè)

【文章目錄】：
1 Introduction
2 Role of AER in proximodistal patterning
    2.1 Current models for specifying positional in-formation in proximodistal patterning
    2.2 Molecular and genetic bases of proximodistal patterning
    2.3 Roles of FGF10 signalling in pre-AER and post-AER induction
3 Role of AER in anteroposterior patterning
4 Role of AER in dorsoventral patterning
5 Role of AER in shaping the developing limb
6 Signalling interactions across different signalling centres during limb development
7 Conclusions
Contributors
Compliance with ethics guidelines



本文編號(hào)：3448436