目的:應(yīng)用功能核磁共振影像（fMRI）研究針刺風(fēng)池穴后的持續(xù)大腦效應(yīng)。背景:針灸是在中國應(yīng)用了上千年的古老治療方法。現(xiàn)在針灸被作為一種輔助替代治療方法,其治療效果在西方世界正在逐漸被認(rèn)可。根據(jù)中醫(yī)針灸理論,每個(gè)穴位都有其特定的功能。不同的穴位有特定的治療效果,因此刺激某一特定的穴位可以治療特定的病證。穴位的治療是通過經(jīng)絡(luò)得以實(shí)現(xiàn)的,因此針灸刺激同一經(jīng)脈上的穴位可以引發(fā)相似的激活模式。盡管針灸已有很長(zhǎng)的歷史,公眾也已接受這種醫(yī)學(xué)方法,然而針灸治療的確切的生理機(jī)制仍不清楚,還需要進(jìn)一步的研究。功能核磁共振影像因?yàn)槠淇梢灾苯訙y(cè)量針刺引起的腦的活動(dòng)和腦狀態(tài)的功能變化,以及可以發(fā)現(xiàn)連接的類型,而沒有放射性或侵入,已得到廣泛應(yīng)用。風(fēng)池是針灸治療頸部僵硬、癲癇、偏頭痛、目疾的主要穴位。盡管關(guān)于其顯著治療效果的臨床研究報(bào)導(dǎo)很多,而其作用機(jī)制還不是很清楚。雖然通過功能影像和神經(jīng)科學(xué),研究者已發(fā)現(xiàn)刺激某一特定穴位在相對(duì)特定的腦網(wǎng)絡(luò)會(huì)引起血液動(dòng)力學(xué)變化,然而針刺風(fēng)池穴后在大腦皮層連接的持續(xù)變化還未進(jìn)行研究。本研究,對(duì)11位健康受試者在針刺風(fēng)池穴之前和之后進(jìn)行了大腦fMRI檢測(cè)。觀察了大腦fMRI的活動(dòng)變化和... 

【文章來源】：北京中醫(yī)藥大學(xué)北京市 211工程院校 教育部直屬院校

【文章頁數(shù)】：114 頁

【學(xué)位級(jí)別】：碩士

【文章目錄】：
ABSTRACT
摘要
Abbreviations
Part One: The review of fMRI in acupuncture research
    1. Introduction
    2. Acupuncture and fMRI review
        2.1. Neural mechanisms of acupuncture
        2.2. Acupuncture and fMRI
        2.3. Acupuncture and De Qi
        2.4. De Qi and fMRI
        2.5. De Qi and MASS
        2.6. Acupuncture and Western Medicine
Part two: Review for the anatomy, indication and mechanism of acupuncture at GB20
    1. Introduction
    2. Western Medicine view on GB20
        2.1 GB20 Anatomy
    3. Traditional Chinese Medicine view on GB20
        3.1. The Gallbladder Channel of Foot Shaoyang
        3.2. Function of GB20
        3.3. Needling depth of GB20
    4. Literature Review about the indications of GB20
        4.1. Migraine
        4.2. Epilepsy
        4.3. Stroke
        4.4. Ophthalmologic diseases
        4.5. Facial paralysis
        4.6. Hypertension
        4.7. Pain
        4.8. Others
Part Three: Clinical Study-The sustained brain effects after needling at Fengchi (GB20)Measured by fMR
    1. Purpose of the study
    2. Material and Methods
        2.1. Study Design
        2.2. Participants
            2.2.1. Inclusion Criteria
            2.2.2. Exclusion Criteria
        2.3. Intervention
            2.3.1. Stimuli
            2.3.2. Psychophysical response
            2.3.3. fMRI Acquisitions
            2.3.4. Scanning procedures
        2.4. Outcome measurements
            2.4.1. MASS
            2.4.2. fMRI
        2.5. Statistical Analysis
            2.5.1. Psychophysical Data Analysis
            2.5.2. fMRI Preprocessing
            2.5.3. fMRI Data Analysis
    3. Results
        3.1. Psychophysical Response (needle sensation)
        3.2. Neuroimaging Results
            3.2.1. fALFF and ReHo analysis
            3.2.2. Centrality mapping analysis
            3.2.3. Functional Connectivity analysis
    4. Discussion
        4.1. The activated Brain areas and networks and their functions
            4.1.1. Relationship between the GB20 and vision area
            4.1.2. Relationship between DMN and the GB20 and other acupoints
        4.2. Relationship between the GB20 and GB37 based on meridian theory
        4.3. Relationship between needle sensation and nerve fiber
    5. Adverse events
    6. Advantages
    7. Limitations
    8. Suggestions
    9. Conclusion
References
Appendices
Acknowledgements



本文編號(hào)：3172930