【摘要】：目的探討腎損傷分子(Kim-1)、人中性粒細(xì)胞明膠酶相關(guān)脂質(zhì)運(yùn)載蛋白(NGAL)、人纖溶酶原激活物抑制因子-1(PAI-1)及熱休克蛋白72(Hsp72)聯(lián)合檢測對(duì)糖尿病早期腎損害的診斷價(jià)值。方法將180例2型糖尿病患者按尿蛋白水平分為尿蛋白陰性組(n=58)和尿蛋白陽性組(n=122),以同時(shí)期60例尿蛋白檢查陰性的健康體檢者為對(duì)照組。采用ELISA法檢測各組尿Kim-1、NGAL、PAI-1及Hsp72水平,采用ROC曲線分析各標(biāo)志物單一及不同組合對(duì)糖尿病早期腎損害的診斷價(jià)值。結(jié)果各組間Kim-1、NGAL、PAI-1及Hsp72水平存在顯著差異(P0.01),以尿蛋白陽性組水平最高,尿蛋白陰性組次之,對(duì)照組最低。單一標(biāo)志物檢測時(shí),Kim-1敏感度最強(qiáng)(77.2%),Hsp72特異度最強(qiáng)(90.0%),二者ROC曲線下面積(AUC)分別為0.879和0.877。兩項(xiàng)聯(lián)合檢測中,Kim-1+Hsp72敏感度最強(qiáng)(90.6%),Kim-1+PAI-1特異度最強(qiáng)(96.7%);三項(xiàng)聯(lián)合檢測中,Kim-1+PAI-1+Hsp72的敏感度和特異度最高,分別為91.1%和97.0%。結(jié)論 Kim-1和Hsp72聯(lián)合檢測在糖尿病早期腎損害診斷中具有較高的敏感度和特異度,必要時(shí)可聯(lián)合PAI-1進(jìn)行檢測,以提高診斷的準(zhǔn)確性。
[Abstract]:Objective to investigate renal injury molecule (Kim-1), human neutrophil gelatinase-associated lipid delivery protein (NGAL),). The diagnostic value of combined detection of human plasminogen activator inhibitor-1 (PAI-1) and heat shock protein 72 (Hsp72) in early diabetic nephropathy. Methods 180 patients with type 2 diabetes mellitus were divided into two groups according to urinary protein level: urine protein negative group (n = 58) and urine protein positive group (n = 122). 60 healthy subjects with negative urine protein test were used as control group at the same time. The levels of urinary Kim-1,NGAL,PAI-1 and Hsp72 in each group were measured by ELISA method. The diagnostic value of single marker and different combination of each marker in early renal damage of diabetes mellitus was analyzed by ROC curve. Results there were significant differences in the levels of Kim-1,NGAL,PAI-1 and Hsp72 among the three groups (P0.01). The urinary protein positive group was the highest, the urine protein negative group was the second, and the control group was the lowest. The sensitivity of Kim-1 was the strongest (77.2%) and the specificity of Hsp72 was the strongest (90.0%). The area (AUC) under ROC curve was 0.879 and 0.877 respectively. The sensitivity of Kim-1 Hsp72 was the strongest (90.6%) and the specificity of Kim-1 PAI-1 was the strongest (96.7%). The sensitivity and specificity of Kim-1 PAI-1 Hsp72 were 91. 1% and 97. 0% respectively. Conclusion the combined detection of Kim-1 and Hsp72 has high sensitivity and specificity in the diagnosis of early diabetic renal damage. If necessary, it can be detected in combination with PAI-1 in order to improve the accuracy of diagnosis.
【作者單位】： 瓊海市人民醫(yī)院檢驗(yàn)科;瓊海市人民醫(yī)院內(nèi)分泌科;
【分類號(hào)】：R587.2;R692.9;R446.1

【參考文獻(xiàn)】

相關(guān)期刊論文 前4條

1 霍文謙;張克勤;;腎損傷分子-1在腎小管上皮細(xì)胞缺氧損傷中的保護(hù)作用[J];重慶醫(yī)學(xué);2015年17期

2 劉紅;尹傳妍;劉穎;岳華;陸晨;;糖尿病早期腎損害尿液不同診斷指標(biāo)檢測意義[J];中華實(shí)用診斷與治療雜志;2013年10期

3 高琨;翁國斌;;腎臟缺血再灌注損傷標(biāo)志Hsp72和NF-B的研究進(jìn)展[J];現(xiàn)代實(shí)用醫(yī)學(xué);2011年08期

4 陸菊明,潘長玉;糖尿病腎病的流行病學(xué)和診斷標(biāo)準(zhǔn)[J];中華老年多器官疾病雜志;2002年03期

【共引文獻(xiàn)】

相關(guān)期刊論文 前10條

1 李莎;王麗;;百令膠囊治療早期糖尿病腎病患者的臨床療效研究[J];中國實(shí)用醫(yī)藥;2017年16期

2 譚錦玲;;代謝綜合征與2型糖尿病慢性并發(fā)癥的相關(guān)性探討[J];中國現(xiàn)代醫(yī)生;2017年14期

3 邱志興;;胱抑素C、β2-微球蛋白及尿微量清蛋白對(duì)糖尿病患者早期腎損害的診斷價(jià)值[J];青島醫(yī)藥衛(wèi)生;2017年02期

4 林永梅;陳映;陳Y鐸，

本文編號(hào)：2463225