發(fā)布時間：2018-12-20 16:05

【摘要】：目的評價預存式自體輸血對擇期手術患者術后免疫功能的影響。方法選擇本院2015年11月-2016年8月符合預存式自體輸血指征的擇期手術患者51名,分為自體血組(n=20):術前采集自體血、術中回輸;異體血組(n=15):術前未預存自體血,術中輸異體血。未輸血組(n=16):術前未預存自體血,術中未輸注異體血。分析比較3組患者術前、術后1 d和5 d CD3+、CD4+、CD8+、CD4+/CD8+和NK細胞的變化。結果術后1 d,CD3+(%)、CD4+(%)及NK細胞數(shù)(×109),自體血組較異體血組與未輸血組分別為59.81±5.82 vs 50.04±4.37 vs 56.28±5.56,31.06±5.77 vs 22.88±3.80 vs 29.00±2.77,0.17±0.06 vs 0.12±0.05 vs 0.17±0.05,自體血組較異體血組明顯升高(P0.05);術后5 d CD3+(%)、CD4+(%)、CD4/CD8、NK細胞比例(%)及絕對計數(shù)(×109),自體血組、異體血組與未輸血組分別為69.56±6.02 vs 59.81±5.38 vs 67.93±7.89,42.91±6.08 vs 31.14±3.99 vs 43.40±3.31,1.73±0.36 vs 1.23±0.37 vs 1.77±0.46,12.53±4.33 vs 7.84±3.41 vs 12.11±3.72,0.21±0.11 vs 0.10±0.06 vs 0.18±0.06),自體血組較異體血組明顯升高(P0.05)。結論預存式自體輸血較異體輸血對于患者術后免疫功能影響較小,對細胞免疫功能有正向調(diào)節(jié)作用。
[Abstract]:Objective to evaluate the effect of preexisting autologous blood transfusion on postoperative immune function in patients undergoing elective operation. Methods from November 2015 to August 2016, 51 patients were selected and divided into autologous blood group (n = 20) and autologous blood group (n = 20). Autologous blood was collected before operation and reinfused during operation. Allogeneic blood group (nm15): no autologous blood was stored before operation and allogeneic blood was infused during operation. No autologous blood was prestored before operation and allogeneic blood was not infused during operation in no transfusion group (n = 16). The changes of CD3, CD4, CD8, CD4 / CD8 and NK cells before and after operation were analyzed and compared in three groups. Results 1 day after operation, CD3 (%), CD4 (%) and the number of NK cells (脳 10 ~ 9) were found. Autologous blood group was 59.81 鹵5.82 vs 50.04 鹵4.37 vs 56.28 鹵5.56 vs 31.06 鹵5.77 vs 22.88 鹵3.80 vs 29.00 鹵2.77 vs 0.17 鹵0.06 vs 0.12 鹵0.05 vs 0.17 鹵0.05 vs respectively. Autologous blood group was significantly higher than that of allogeneic blood group (P0.05). CD3 (%), CD4 (%), percentage of CD4/CD8,NK cells (%) and absolute count (脳 10 ~ 9) were found in autologous blood group 5 days after operation. The vs of allogeneic blood group and non-transfusion group were 69.56 鹵6.02 vs 59.81 鹵5.38 vs 67.93 鹵7.89 vs 42.91 鹵6.08 vs 31.14 鹵3.99 vs 43.40 鹵3.31 vs 1.73 鹵0.36 vs 1.23 鹵0.37 vs 1.77 鹵0.4612.53 鹵4.33 vs 7.84 鹵3.33 respectively. 41 vs 12.11 鹵3.72 vs 0.21 鹵0.11 vs 0.10 鹵0.06 vs 0.18 鹵0.06). Autologous blood group was significantly higher than that of allogeneic blood group (P0.05). Conclusion Preexisting autologous blood transfusion has less effect on postoperative immune function than allogeneic blood transfusion, and has a positive effect on cellular immune function.
【作者單位】： 陸軍總醫(yī)院輸血科陸軍血液中心;陸軍總醫(yī)院附屬八一兒童醫(yī)院兒童血液腫瘤科;
【基金】：北京市科技計劃課題首都臨床特色應用研究”專項(Z161100000516166)
【分類號】：R457.1
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本文編號：2388218