【摘要】：目的了解浙江沿海地區(qū)無(wú)償獻(xiàn)血者人類(lèi)嗜T淋巴細(xì)胞病毒(HTLV)感染狀況,提出綜合性防控策略。方法采用ELISA方法篩查2013-2015年浙江省沿海6市(區(qū))無(wú)償獻(xiàn)血者58 609(人)份血清中抗-HTLV-Ⅰ/Ⅱ,陽(yáng)性者以WB法確證,并做HTLV基因測(cè)序和同源性分析;隨機(jī)對(duì)10 197名獻(xiàn)血者開(kāi)展HTLV知曉情況問(wèn)卷調(diào)查。結(jié)果本組獻(xiàn)血者人群的抗-HTLV陽(yáng)性率0.01%(5/58 609),抗體類(lèi)型為抗-HTLV-Ⅰ,均屬世界群世界人種亞型;該5位HTLV感染者均為本地首次獻(xiàn)血者,其中臺(tái)州市發(fā)現(xiàn)的HTLV毒株與福建泉州的分離株同源,舟山市發(fā)現(xiàn)的HTLV毒株與日本的分離株MT-2同源。獻(xiàn)血者對(duì)HTLV的知曉情況:隨機(jī)問(wèn)卷調(diào)查(10分制)人均得分0.75(0-8)分,其中1分者占調(diào)查對(duì)象的79.0%(8059/10 197),5分者占1.40%(143/10 197)。結(jié)論浙江沿海臺(tái)州和舟山地區(qū)獻(xiàn)血人群中存在HTLV感染和散在的小流行;獻(xiàn)血者對(duì)HTLV的知識(shí)極其匱乏,亟待采取相應(yīng)防控策略。
[Abstract]:Objective to investigate the status of human T lymphocyte virus (HTLV) infection among blood donors in coastal areas of Zhejiang province and to put forward comprehensive prevention and control strategies. Methods ELISA method was used to screen 58 609 (human) samples of free blood donors from 6 coastal cities (districts) of Zhejiang Province from 2013 to 2015. The positive individuals were confirmed by WB method, and HTLV gene sequencing and homology analysis were performed. A questionnaire survey was conducted among 10 197 blood donors on HTLV knowledge. Results the positive rate of anti-HTLV was 0. 01% (5 / 58,609) in this group of blood donors. The antibody type was anti-HTLV- 鈪，

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