北京市腸道門診腹瀉兒童沙門菌感染狀況和耐藥性分析
[Abstract]:Objective to analyze the epidemiological characteristics and drug resistance of Salmonella infection in children under 5 years old in Beijing from 2010 to 2015. Methods fecal specimens were collected from 17 patients with intestinal diseases. Salmonella was isolated and identified, serotyping and drug sensitivity test were performed. Results the positive rate of Salmonella in feces of 3 428 children with diarrhea was 4.6%, mainly 3 years old and 4 years old. Except for one obvious peak in April, there was a continuous peak in summer and autumn. 33 Salmonella serotypes were isolated, of which Salmonella enteritis accounted for 34.6m and Salmonella typhimurium accounted for 16.0. Salmonella showed high resistance to classical antibiotics such as sulfamethoxazole (60.6%), naphthalic acid (56.8%), streptomycin and ampicillin (50.3%), and showed moderate resistance to amoxicillin clavulanic acid, tetracycline and doxycycline. The drug resistance rates of ceftriaxone, cefepime and ciprofloxacin were 31.0% and 29.7%, respectively, and were 7.7% and 7.1% for ceftriaxone, cefepime and ciprofloxacin, respectively. The multidrug resistant strains showed an obvious upward trend with the increase of age, and at least three kinds of antibiotic resistant strains accounted for 58.1%. Conclusion Salmonella infection in children with diarrhea in Beijing is high in age 3 and 4 years old. Salmonella enteritidis and Salmonella typhimurium are the main serotypes, and multidrug resistance is becoming more and more serious.
【作者單位】: 北京市疾病預(yù)防控制中心北京市預(yù)防醫(yī)學(xué)研究中心食物中毒診斷溯源技術(shù)北京市重點實驗室;
【基金】:北京市高層次衛(wèi)生技術(shù)人才培養(yǎng)計劃(2013-3-099) “十三五”傳染病國家科技重大專項(2017ZX10104002-003-002)
【分類號】:R446.5;R725.1
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