【摘要】：目的探討老年維持性血液透析(MHD)患者心理健康狀況與神經(jīng)營養(yǎng)因子(NTF)的相關性。方法選擇2014年1月至2015年1月在該院血液透析中心接受血液透析治療的老年MHD患者228例及老年健康體檢志愿者40例(對照組),采用抑郁自評量表(SDS)和焦慮自評量表(SAS)評價研究對象的抑郁和焦慮得分,采集清晨空腹血檢測血紅蛋白(Hb)、總蛋白(TP)、白蛋白(Alb)、前白蛋白(PA)、血肌酐(SCr)、血尿素氮(BUN)、血鈣(Ca)、血磷(P)和腦源性NTF(BDNF)、神經(jīng)營養(yǎng)因子3(NT-3),采用Logistic回歸分析抑郁和焦慮與血清各指標的相關性。結果MHD患者抑郁和焦慮發(fā)生率顯著高于對照組(P0.05);抑郁組和非抑郁組Hb、Tb、Alb、Ca、P水平均顯著低于對照組(P0.05),Scr、BUN水平均顯著高于對照組(P0.05)、焦慮組和非焦慮組Hb、Tb、Alb、Ca、P水平均顯著低于對照組(P0.05),SCr、BUN、NT-3水平顯著高于對照組(P0.05);影響抑郁得分的影響因子為Hb、BDNF和NT-3,影響焦慮得分的影響因子為NT-3。結論老年MHD患者抑郁、焦慮發(fā)病率顯著高于正常人群,抑郁得分的影響因子是Hb、BDNF和NT-3,焦慮得分的影響因子是NT-3,在醫(yī)療實踐中應該加強檢測。
[Abstract]:Objective to investigate the correlation between mental health and neurotrophic factor (NTF) in elderly patients with maintenance hemodialysis (MHD). Methods from January 2014 to January 2015, 228 elderly MHD patients treated with hemodialysis and 40 healthy volunteers (control group) received hemodialysis from January 2014 to January 2015. Self-rating Depression scale (SDS) and Self-rating anxiety scale (SAS) were used. The depression and anxiety scores of the subjects were evaluated by (SAS). Fasting blood samples were collected to detect serum levels of (Hb), total protein, (TP), albumin, prealbumin, (PA), serum creatinine, (SCr), urea nitrogen, (BUN), serum calcium, (Ca), phosphorus (P) and brain-derived NTF (BDNF), neurotrophic factor 3 (NT-3). Logistic regression analysis was used to analyze the correlation between depression and anxiety and serum indexes. Results the incidence of depression and anxiety in patients with MHD was significantly higher than that in control group (P0.05), the level of Hb,Tb,Alb,Ca,P in depression group and non-depression group was significantly lower than that in control group (P0.05), the level of Scr,BUN was significantly higher than that in control group (P0.05), and the Hb,Tb,Alb,Ca,P level in anxiety group and non-anxiety group was significantly lower than that in control group (P0.05). In the group (P0.05), the level of SCr,BUN,NT-3 was significantly higher than that in the control group (P0.05), and the influencing factors of depression score were Hb,BDNF and NT-3, the influencing factors of anxiety score were NT-3.. Conclusion the incidence of depression and anxiety in elderly patients with MHD is significantly higher than that in normal subjects. The influencing factors of depression scores are Hb,BDNF and NT-3, anxiety scores. NT-3, should be strengthened in medical practice.
【作者單位】： 首都醫(yī)科大學附屬北京朝陽醫(yī)院西院;
【分類號】：R473.5

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