【摘要】：采用近紅外光譜法無創(chuàng)測量人體血糖時(shí),葡萄糖濃度變化引起的光強(qiáng)信號(hào)微弱,為了實(shí)現(xiàn)目標(biāo)測量精度,需要選擇適宜的測量波長使葡萄糖引起的吸收信號(hào)水平強(qiáng)于噪聲信號(hào)水平.本文提出了基于最佳光程長的測量波長選擇原則,可在測量靈敏度最大的條件下,評(píng)價(jià)葡萄糖吸收光譜的測量是否可行.以葡萄糖在水溶液中的測量為例,基于最佳光程長理論,對(duì)1 000~2 500 nm的每個(gè)波長均進(jìn)行光程優(yōu)化,以1 mmol/L的檢測濃度為目標(biāo),篩選了可行的測量波段.結(jié)果表明,即使在最佳光程長下檢測,該檢測目標(biāo)對(duì)測量光譜的重復(fù)性信噪比要求也非常高,當(dāng)SNR達(dá)到10 000∶1時(shí),僅有4個(gè)波段滿足要求,分別是:1 000~1 160 nm,1 375~1 420 nm,1 590~1 640 nm和1 870~1 910 nm.其中短波長波段1 000~1 160 nm對(duì)光譜信噪比的要求最低,且最佳光程長最長,皮膚穿透深度最大,顯示了較好的應(yīng)用前景.這一結(jié)果對(duì)皮膚中的葡萄糖測量的波長選擇有較好的參考價(jià)值.此外,本文所提出的波長選擇方法也同樣適用于采用吸收光譜法對(duì)其他物質(zhì)成分的測量.
[Abstract]:In order to achieve the accuracy of target measurement, the signal of light intensity caused by the change of glucose concentration is weak when using near infrared spectroscopy (NIR) to measure human blood glucose noninvasively. It is necessary to choose the appropriate measurement wavelength to make the level of absorption signal caused by glucose stronger than that of noise signal. In this paper, the principle of wavelength selection based on optimal optical path length is proposed, which can be used to evaluate the feasibility of glucose absorption spectrum measurement under the condition of maximum measurement sensitivity. Taking the measurement of glucose in aqueous solution as an example, based on the theory of optimal optical path length, the optical path of each wavelength of 1 000 ~ (2 500) nm was optimized. The feasible wave band was screened with the detection concentration of 1 mmol/L as the target. The results show that even under the optimal optical path length detection, the target has a very high signal to noise ratio (SNR) requirement for the measurement spectrum. When the SNR reaches 10 000: 1, only 4 bands meet the requirements. They are: 1 000 1 160 nm,1 375 1 420 nm,1 590 1 640 nm and 1 870 1 910 nm. The spectral signal-to-noise ratio (SNR) is the lowest in the short wavelength band of 1 000 ~ 1 160 nm, and the best optical path is the longest and the skin penetration depth is the largest, which shows a good prospect of application. This result has good reference value for the wavelength selection of glucose measurement in skin. In addition, the wavelength selection method proposed in this paper is also suitable for the measurement of other substances by absorption spectrometry.
【作者單位】： 精密測試技術(shù)及儀器國家重點(diǎn)實(shí)驗(yàn)室(天津大學(xué));
【基金】：國家高技術(shù)研究發(fā)展計(jì)劃(863計(jì)劃)資助項(xiàng)目(2012AA022602,2012YQ090194) 國家自然科學(xué)基金資助項(xiàng)目(60938002,81471698)
【分類號(hào)】：O657.33;R446.1

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