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實(shí)驗(yàn)兔皮內(nèi)、皮下注射釓雙胺行間質(zhì)MR淋巴管成像對(duì)脊柱旁淋巴干顯像的對(duì)比分析

發(fā)布時(shí)間:2018-06-20 17:46

  本文選題:磁共振成像 + 淋巴管造影術(shù); 參考:《中國(guó)醫(yī)學(xué)影像技術(shù)》2017年08期


【摘要】:目的探討經(jīng)兔足背皮內(nèi)、皮下注射釓雙胺行脊柱旁淋巴干MR成像的可行性。方法選取新西蘭大白兔8只,首先經(jīng)足背皮內(nèi)注射釓雙銨(皮內(nèi)組),間隔3天后再經(jīng)皮下注射(皮下組),采集冠狀位三維擾相梯度回波序列(fl3dcor)圖像,分別評(píng)價(jià)腰淋巴干及胸導(dǎo)管的顯示情況。結(jié)果皮內(nèi)組顯示所有兔兩側(cè)乆窩淋巴結(jié)、髂淋巴結(jié)及主動(dòng)脈下淋巴結(jié)明顯強(qiáng)化,強(qiáng)化持續(xù)時(shí)間大于30min,最長(zhǎng)達(dá)90min;6例腰淋巴干全程及乳糜池明顯強(qiáng)化;5例可見(jiàn)部分胸導(dǎo)管強(qiáng)化。皮下組顯示所有兔兩側(cè)乆窩淋巴結(jié)均明顯強(qiáng)化,但腰淋巴結(jié)、腰淋巴干及胸導(dǎo)管未見(jiàn)強(qiáng)化。腰淋巴干及胸導(dǎo)管強(qiáng)化程度總評(píng)分皮內(nèi)組與皮下組差異有統(tǒng)計(jì)學(xué)意義(t=100.00,P=0.0002)。結(jié)論足背皮內(nèi)注射釓雙胺淋巴管成像能較皮下注射更好地顯示腰干淋巴管。
[Abstract]:Objective to investigate the feasibility of subcutaneous injection of gadolinium diamine in paraspinal lymphoid trunk Mr imaging. Methods eight New Zealand white rabbits were selected. First, gadolinium bisammonium was injected into the dorsum of foot (intradermal group), then subcutaneously injected (subcutaneous group) after 3 days interval. The coronal 3D scrambling phase gradient echo sequence fl3dcorwas collected. To evaluate the display of lumbar lymphatic trunk and thoracic duct respectively. Results in the intradermal group, the bilateral flanking lymph nodes, iliac lymph nodes and subaortic lymph nodes were obviously enhanced, and the enhancement lasted longer than 30 min. The longest time was 90 min in 6 cases of lumbar lymphoid trunk and chylous cistern, and 5 cases showed partial enhancement of thoracic ducts. In the subcutaneous group, all the flanking lymph nodes were obviously enhanced, but the lumbar lymph nodes, trunk of lumbar lymph nodes and thoracic ducts were not enhanced. Total score of Lumbar lymphoid Trunk and Thoracic Catheter Enhancement degree the difference between the intradermal group and the subcutaneous group was statistically significant. Conclusion Intradermal injection of gadolinium diamine lymphatic vessel imaging can better display lumbar lymphatic vessels than subcutaneous injection.
【作者單位】: 浙江大學(xué)醫(yī)學(xué)院附屬兒童醫(yī)院放射科;杭州市兒童醫(yī)院放射科;湖州市婦幼保健院放射科;
【基金】:2014年浙江省醫(yī)藥衛(wèi)生科技計(jì)劃項(xiàng)目(2014KYA121)
【分類號(hào)】:R445.2

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