發(fā)布時(shí)間：2018-06-20 04:30

  本文選題：慢性腎臟病 + 氧化應(yīng)激��； 參考：《預(yù)防醫(yī)學(xué)》2017年04期

【摘要】：目的探討氧化應(yīng)激相關(guān)指標(biāo)在慢性腎臟病(CKD)早期診斷和病情評(píng)估中的價(jià)值。方法選擇2014年8月—2015年12月在浙江大學(xué)醫(yī)學(xué)院附屬第二醫(yī)院腎臟內(nèi)科住院治療的CKD患者220例,選擇2015年12月在該醫(yī)院體檢正常的100人作為對(duì)照。分別測(cè)定兩組血清肌酐(Cr)、尿酸(UA)、γ-谷氨酰轉(zhuǎn)肽酶(GGT)、同型半胱氨酸(HCY)水平,并比較兩組差異。根據(jù)Cr水平,估算腎小球?yàn)V過率(GFR),劃定CKD臨床分期。采用受試者工作特征(ROC)曲線比較CKD I、CKD II組患者和對(duì)照組UA、GGT、HCY單項(xiàng)檢測(cè)及3項(xiàng)聯(lián)合檢測(cè)的準(zhǔn)確性。結(jié)果 CKD組血清Cr、UA、GGT、HCY水平均高于對(duì)照組(P0.05),在CKD組與對(duì)照組的鑒別診斷研究中,UA、GGT、HCY單項(xiàng)和3項(xiàng)聯(lián)合檢測(cè)的ROC曲線下面積(AUC)值分別為0.823、0.585、0.850和0.924,單項(xiàng)臨床診斷價(jià)值均低于3項(xiàng)聯(lián)合(P0.05)。在CKDⅠ組與對(duì)照組的鑒別診斷研究中,UA、GGT、HCY單項(xiàng)和3項(xiàng)聯(lián)合檢測(cè)的AUC值分別為0.711、0.594、0.716和0.807,單項(xiàng)臨床診斷價(jià)值均低于3項(xiàng)聯(lián)合(P0.05)。在CKDⅠ組與Ⅱ組的鑒別診斷研究中,3項(xiàng)聯(lián)合檢測(cè)的AUC值為0.834,與HCY單項(xiàng)檢測(cè)的AUC值0.828相比,差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論 UA、GGT、HCY 3項(xiàng)指標(biāo)的聯(lián)合檢測(cè)在CKD早期臨床診斷中具有較高的應(yīng)用價(jià)值,在CKD晚期單獨(dú)檢測(cè)HCY與3項(xiàng)聯(lián)合檢測(cè)的診斷價(jià)值相近。
[Abstract]:Objective to investigate the value of oxidative stress related indexes in early diagnosis and evaluation of chronic kidney disease (CKD). Methods 220 patients with CKD were selected from August 2014 to December 2015 in the second affiliated Hospital of Zhejiang University Medical College, and 100 patients who had normal physical examination in the hospital were selected as control. Serum creatinine (Cr), uric acid (UAA), 緯 -glutamyl transpeptidase (GGTN) and homocysteine (HCY) were measured in the two groups, and the differences between the two groups were compared. According to the level of Cr, the glomerular filtration rate (GFR) was estimated and the clinical stage of CKD was determined. The accuracy of single test and three items of combined detection of UAG GTN HCY in CKD Igna CKD II group and control group were compared by using the operating characteristics of the subjects. Results the level of GGTHCY in serum of CKD group was higher than that of control group (P 0.05). In the differential diagnosis of CKD group and control group, the area under ROC curve was 0.823 鹵0.5850.850 and 0.924, respectively, and the value of single clinical diagnosis was lower than that of P0.05. In the study of differential diagnosis between CKD 鈪，

本文編號(hào)：2042963