本文選題：奇異變形菌 + 耐藥性　； 參考：《中華醫(yī)院感染學(xué)雜志》2017年12期

【摘要】：目的了解醫(yī)院奇異變形菌感染分布情況及耐藥變遷,為臨床合理使用抗菌藥物提供參考。方法對(duì)2005年1月-2015年12月醫(yī)院分離的奇異變形菌的分布及耐藥情況進(jìn)行統(tǒng)計(jì)分析。結(jié)果 11年非重復(fù)分離奇異變形菌共1442株,占所有住院患者非重復(fù)分離腸桿菌科細(xì)菌的6.87%,且分離率波動(dòng)不大;主要分離于痰、尿、分泌物及血標(biāo)本等,分別占32.11%、34.81%、14.42%和1.25%;藥敏結(jié)果顯示奇異變形菌對(duì)哌拉西林、哌拉西林/他唑巴坦、頭孢替坦、頭孢他啶、頭孢吡肟、氨曲南、亞胺培南、美洛培南、阿米卡星及頭孢哌酮/舒巴坦等的耐藥率較低,分別為9.42%、1.09%、1.65%、6.42%、7.54%、3.96%、1.43%、0.14%、5.83%和4.06%,可作為經(jīng)驗(yàn)首選藥;氨芐西林、頭孢唑林和磺胺甲VA唑/甲氧芐啶耐藥率較高,分別為52.56%、58.37%和51.67%,需加強(qiáng)臨床使用規(guī)范;從呼吸道分離的奇異變形菌對(duì)頭孢替坦、頭孢他啶及阿米卡星的耐藥率高于從尿液分離的奇異變形菌,而對(duì)環(huán)丙沙星的耐藥率低于從尿液中分離的奇異變形菌,均具有統(tǒng)計(jì)學(xué)差異。結(jié)論加強(qiáng)醫(yī)院感染細(xì)菌學(xué)的檢測(cè)和動(dòng)態(tài)分析,對(duì)制定有效感染控制措施及杜絕感染暴發(fā)具有重要意義。
[Abstract]:Objective to investigate the distribution of Proteus mirabilis infection and the change of drug resistance in hospital, and to provide reference for rational use of antimicrobial agents in clinic. Methods the distribution and drug resistance of Proteus mirabilis isolated from hospitals from January 2005 to December 2015 were analyzed statistically. Results A total of 1442 strains of non-repeated isolates of Proteus mirabilis were isolated in 11 years, accounting for 6.87% of all non-repeated isolates of Enterobacteriaceae, and the isolation rate was not significant. The isolates were mainly isolated from sputum, urine, secretions and blood samples. 14.42% and 1.25%, respectively, of 32.110.81% and 1.25%, respectively. The results of antimicrobial susceptibility showed that Proteus mirabilis was resistant to piperacillin, piperacillin / tazobactam, ceftitan, ceftazidime, cefepime, aztreonam, imipenem, and meropenem. The drug resistance rates of amikacin and cefoperazone / sulbactam were lower, 9.42 and 1.09, respectively, and 1.65 and 6.42, respectively. The drug resistance rate of ampicillin, cefazolin and sulfamethoxazole / trimethoprim was higher than that of ampicillin, cefazolin and sulfamethoxazole / trimethoprim, and the drug resistance rate of amicacin and cefazolin was higher than that of ampicillin, cefazolin and sulfamethoxazole / trimethoprim. 58.37% and 51.67%, respectively, of 52.56% and 51.67%, respectively. The resistance rate of Proteus mirabilis isolated from respiratory tract to ceftitan, ceftazidime and amikacin was higher than that of urine. The resistance to ciprofloxacin was significantly lower than that of Proteus mirabilis isolated from urine. Conclusion strengthening the detection and dynamic analysis of nosocomial infection bacteriology is of great significance in making effective infection control measures and preventing infection outbreak.
【作者單位】： 天津市第一中心醫(yī)院檢驗(yàn)科;
【基金】：天津市衛(wèi)生局面上基金資助項(xiàng)目(2015KY10)
【分類(lèi)號(hào)】：R446.5

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本文編號(hào)：1997588