本文選題：血小板生成素 + 血小板　； 參考：《中國實(shí)驗(yàn)血液學(xué)雜志》2017年03期

【摘要】：目的:探討血小板生成素(thrombopoietin,TPO)在不同病因引起的急性炎癥反應(yīng)狀態(tài)下的變化情況,并進(jìn)一步探討其意義。方法:采用病例對(duì)照分析,納入65例處于急性炎癥反應(yīng)狀態(tài)病人作為研究組(其中急性心肌梗死病人15例,急性腦梗死病人15例,急性創(chuàng)傷病人25例,急性肺炎病人10例),42例健康人群作為對(duì)照組。使用獨(dú)立樣本t檢驗(yàn)方法,對(duì)總炎癥疾病組與對(duì)照組的外周血TPO及各系血細(xì)胞計(jì)數(shù)進(jìn)行比較,評(píng)估急性炎癥狀態(tài)下TPO的水平是否高于健康人群;并使用獨(dú)立樣本Kruskal-Wallis H檢驗(yàn)及Nemenyi法檢驗(yàn)進(jìn)一步進(jìn)行亞組分析,評(píng)估在不同病因及不同水平炎癥狀態(tài)下TPO水平是否存在差別。結(jié)果:與對(duì)照組相比,總炎癥疾病組的TPO水平明顯升高(181.11±35.38 vs 96.13±9.7 pg/ml,P0.001),且總炎癥疾病組白細(xì)胞數(shù)(9.64±3.43)×10~9/L也明顯高于對(duì)照組(7.35±1.49)×10~9/L(P0.001)。然而,總炎癥疾病組血小板計(jì)數(shù)與對(duì)照組相比并無統(tǒng)計(jì)學(xué)差異(P=0.313)。在進(jìn)一步的亞組分析中發(fā)現(xiàn),不同炎癥水平狀態(tài)下TPO水平的變化有不同。高炎癥水平狀態(tài)疾病(急性創(chuàng)傷、急性肺炎)TPO水平較低炎癥水平疾病(急性心肌梗死、急性腦梗死)TPO水平明顯升高(P0.05),且各組間血小板計(jì)數(shù)并無明顯統(tǒng)計(jì)學(xué)差異。結(jié)論:在急性炎癥狀態(tài)下,TPO血清水平的升高與血小板數(shù)無明顯相關(guān),但與炎癥水平具有相關(guān)性,并且TPO可能作為一種急性期反應(yīng)蛋白對(duì)機(jī)體產(chǎn)生保護(hù)性作用。
[Abstract]:Aim: to investigate the changes of thrombopoietin (TPO) in acute inflammatory reaction induced by different etiology and its significance. Methods: a case-control analysis was carried out in 65 patients with acute inflammatory reaction (including 15 patients with acute myocardial infarction, 15 patients with acute cerebral infarction and 25 patients with acute trauma), including 15 patients with acute myocardial infarction, 15 patients with acute cerebral infarction and 25 patients with acute trauma. Ten patients with acute pneumonia and 42 healthy people were used as control group. The peripheral blood TPO and blood cell count of the total inflammatory disease group and the control group were compared with that of the control group by using independent sample t-test method to evaluate whether the level of TPO in acute inflammatory state was higher than that in healthy population. Kruskal-Wallis H test and Nemenyi test were used to further analyze the subgroup to assess whether there were differences in TPO levels under different etiological factors and different levels of inflammation. Results: compared with the control group, the level of TPO in the total inflammatory disease group was significantly higher than that in the control group (181.11 鹵35.38 vs 96.13 鹵9.7 PG / ml P 0.001g / L), and the leukocyte count in the total inflammatory disease group was 9.64 鹵3.43 脳 10 ~ (-9) / L, which was significantly higher than that in the control group (7.35 鹵1.49) 脳 10 ~ (9 / L) P _ (0.001). However, there was no significant difference in platelet count between the total inflammatory disease group and the control group. Further subgroup analysis showed that the changes of TPO levels were different at different inflammatory levels. The level of TPO in patients with high inflammatory state (acute trauma, acute pneumonia) was lower than that in patients with acute myocardial infarction (acute myocardial infarction, acute cerebral infarction), the level of TPO was significantly increased (P 0.05), and there was no significant difference in platelet count among the groups. Conclusion: there is no significant correlation between the serum level of TPO and platelet count in acute inflammatory state, but there is a correlation with the level of inflammation, and TPO may play a protective role as a reactive protein in acute phase.
【作者單位】： 南方醫(yī)科大學(xué)南方醫(yī)院血液科;南方醫(yī)科大學(xué)南方醫(yī)院兒科;佛山市第一人民醫(yī)院急診科;江西省腫瘤醫(yī)院內(nèi)一科;
【分類號(hào)】：R446.1

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